A museum of contemporary art for Boston, Massachusetts

Thesis (B.Arch)--Massachusetts Institute of Technology, Dept. of Architecture, 1938.MIT copy bound with: A new city hall for Boston / John J. Noonan. 1938. Accompanying drawings held by MIT Museum.Includes bibliographical references (leaf 31).by Alfred Sweeney, Jr.B.Arc

Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Normal and Dystrophic Mice

Background: Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia. Previously described approaches to blocking myostatin signaling include injection delivery of inhibitory propeptide domain or neutralizing antibodies. Methodology/Principal Findings: Here we describe a unique method of myostatin inhibition utilizing recombinant adenoassociated virus to overexpress a secretable dominant negative myostatin exclusively in the liver of mice. Systemic myostatin inhibition led to increased skeletal muscle mass and strength in control C57 Bl/6 mice and in the dystrophindeficient mdx model of Duchenne muscular dystrophy. The mdx soleus, a mouse muscle more representative of human fiber type composition, demonstrated the most profound improvement in force production and a shift toward faster myosin-heavy chain isoforms. Unexpectedly, the 11-month-old mdx diaphragm was not rescued by long-term myostatin inhibition. Further, mdx mice treated for 11 months exhibited cardiac hypertrophy and impaired function in an inhibitor dose–dependent manner. Conclusions/Significance: Liver-targeted gene transfer of a myostatin inhibitor is a valuable tool for preclinical investigation of myostatin blockade and provides novel insights into the long-term effects and shortcomings of myostatin inhibition o

1936 The Freshman, vol. 3, no. 2

The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. The intent of the publication was to create unity, a sense of community, and class spirit among first year students. Articles include an editorial discussing freshman rules imposed on first-year students and the extension of the rules in response to reported vandalism

1936 The Freshman, vol. 3, no. 1

The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. Here it is! This is the first edition of the FRESHMAN. It is our paper, written by freshmen for freshmen. This first edition is given to you through the courtesy of the M.C.A., and you will soon be called upon to decide whether you wish to subscribe to it. The price will be less than fifty cents for the entire year, and will be added to your class dues. The material within these pages is widely diversified, and every form of freshman activity is included in its scope. Its purpose is to unite a class which is now to the University, and to promote better class spirit

1936 The Freshman, vol. 3, no. 3

The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. The intent of the publication was to create unity, a sense of community, and class spirit among first year students. The paper includes a report on construction of Memorial Gymnasium on the south side of the Armory

1936 The Freshman, vol. 3, no. 4

The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. The intent of the publication was to create unity, a sense of community, and class spirit among first year students

1936 The Freshman, vol. 3, no. 5

The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. The intent of the publication was to create unity, a sense of community, and class spirit among first year students. Included in this issue is an editorial about the impact of hunting and buck fever on women

1936 The Freshman, vol. 3, no. 8

The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. The intent of the publication was to create unity, a sense of community, and class spirit among first year students. Included in this issue are stories related to severe injuries sustained by two female first-year students — Libby Philbrook and Margaret Sewall — as the result of a car accident in Old Town

1936 The Freshman, vol. 3, no. 7

The Freshman was a weekly, student newsletter issued on Mondays throughout the academic year. The newsletter included calendar notices, coverage of campus social events, lectures, and athletic teams. The intent of the publication was to create unity, a sense of community, and class spirit among first year students