A Practical Guide to Municipal Budgeting in Nebraska

The meaning of budgeting is simple and complex. It is simple because budgeting involves making decisions about revenues and expenditures. It is complex because it has many meanings for various people

Budgeting for Nebraska Local Governments

Budgeting is a complex set of activities. To those unfamiliar with its details, it is a mysterious rite conducted annually, and even those familiar with the process give a multitude of definitions. The simplest definition is that budgeting involves the acquisition and allocation of resources

The Formin FMNL3 is a Cytoskeletal Regulator of Angiogenesis

The process of angiogenesis requires endothelial cells (ECs) to undergo profound changes in shape and polarity. Although this must involve remodelling of the EC cytoskeleton, little is known about this process or the proteins that control it. We used a co-culture assay of angiogenesis to examine the cytoskeleton of ECs actively undergoing angiogenic morphogenesis. We found that elongation of ECs during angiogenesis is accompanied by stabilisation of microtubules and their alignment into parallel arrays directed at the growing tip. In other systems, similar microtubule alignments are mediated by the formin family of cytoskeletal regulators. We screened a library of human formins and indentified formin-like 3 (FMNL3; also known as FRL2) as a crucial regulator of EC elongation during angiogenesis. We showed that activated FMNL3 triggers microtubule alignment and that FMNL3 is required for this alignment during angiogenic morphogenesis. FMNL3 was highly expressed in the ECs of zebrafish during development and embryos that were depleted for FMNL3 showed profound defects in developmental angiogenesis that were rescued by expression of the human gene. We conclude that FMNL3 is a new regulator of endothelial microtubules during angiogenesis and is required for the conversion of quiescent ECs into their elongated angiogenic forms

Extrasolar planet science with the Antarctic planet interferometer

The primary limitation to ground based astronomy is the Earth's atmosphere. The atmosphere above the Antarctic plateau is different in many regards compared to the atmosphere at temperate sites. The extreme altitude, cold and low humidity offer a uniquely transparent atmosphere at many wavelengths. Studies at the South Pole have shown additionally that the turbulence properties of the night time polar atmosphere are fundamentally different to mid latitudes. Despite relatively strong ground layer turbulence, the lack of high altitude turbulence combined with low wind speeds presents favorable conditions for interferometry. The unique properties of the polar atmosphere can be exploited for Extrasolar Planet studies with differential astrometry, differential phase and nulling intereferometers. This paper combines the available data on the properties of the atmosphere at the South Pole and other Antarctic plateau sites for Extrasolar Planet science with interferometry

‘It’s like equality now; it’s not as if it’s the old days’: an investigation into gender identity development and football participation of adolescent girls

This article explores the influence participating in football has on the development of adolescent girls’ gender identity, an area which currently lacks academic attention. Data were taken from an ethnographic study with a group of adolescent girls and boys and compared to Jeanes’ research. A social constructionist framework was deployed with links to both critical theory and feminist literature. Qualitative and participatory methods were used to fully engage with the complex issue of gender identity. The girls within this study were aware of the normative gender expectations linked to ‘being a female’ but did not find this restrictive. The girls moved between many changing identities and organised their ‘web of selves’ accordingly. The apparent need to measure success by the parameters of male standards created a barrier to girls’ identity development

Epirubicin With Cyclophosphamide Followed by Docetaxel With Trastuzumab and Bevacizumab as Neoadjuvant Therapy for HER2-Positive Locally Advanced Breast Cancer or as Adjuvant Therapy for HER2-Positive Pathologic Stage III Breast Cancer: A Phase II Trial of the NSABP Foundation Research Group, FB-5

Background The purpose of this study was to determine the cardiac safety and clinical activity of trastuzumab and bevacizumab with docetaxel after epirubicin with cyclophosphamide (EC) in patients with HER2-positive locally advanced breast cancer (LABC) or pathologic stage 3 breast cancer (PS3BC). Patients and Methods Patients received every 3 week treatment with 4 cycles of EC (90/600 mg/m2) followed by 4 cycles of docetaxel (100 mg/m2). Targeted therapy with standard-dose trastuzumab with bevacizumab 15 mg/kg was given for a total of 1 year. Coprimary end points were (1) rate of cardiac events (CEs) in all patients defined as clinical congestive heart failure with a significant decrease in left ventricular ejection fraction or cardiac deaths; and (2) pathologic complete response (pCR) in breast and nodes in the neoadjuvant cohort. An independent cardiac review panel determined whether criteria for a CE were met. Results A total of 105 patients were accrued, 76 with LABC treated with neoadjuvant therapy and 29 with PS3BC treated with adjuvant therapy. Median follow-up was 59.2 months. Among 99 evaluable patients for cardiac safety, 4 (4%; 95% confidence interval [CI], 1.1%-10.0%) met CE criteria. The pCR percentage in LABC patients was 46% (95% CI, 34%-59%). Five-year recurrence-free survival (RFS) and overall survival (OS) for all patients was 79.9% and 90.8%, respectively. Conclusion The regimen met predefined criteria for activity of interest with an acceptable rate of CEs. Although the pCR percentage was comparable with chemotherapy regimens with trastuzumab alone the high RFS and OS are of interest in these high-risk populations

Anomalous charged current couplings of the tau and implications for tau compositeness and two-Higgs doublet models

The leptonic branching fractions of the tau lepton are sensitive to anomalous charged current interactions. We use recent experimental measurements to determine the weak charged current magnetic and electric dipole moments and the Michel parameter $\eta$ with unprecedented precision. These results are then used to constrain the tau compositeness scale and the allowed parameter space for Higgs doublet models.Comment: 3 pages, 1 figur

A case study in adaptable and reusable infrastructure at the Keck Observatory Archive: VO interfaces, moving targets, and more

The Keck Observatory Archive (KOA) (https://koa.ipac.caltech.edu) curates all observations acquired at the W. M. Keck Observatory (WMKO) since it began operations in 1994, including data from eight active instruments and two decommissioned instruments. The archive is a collaboration between WMKO and the NASA Exoplanet Science Institute (NExScI). Since its inception in 2004, the science information system used at KOA has adopted an architectural approach that emphasizes software re-use and adaptability. This paper describes how KOA is currently leveraging and extending open source software components to develop new services and to support delivery of a complete set of instrument metadata, which will enable more sophisticated and extensive queries than currently possible. In August 2015, KOA deployed a program interface to discover public data from all instruments equipped with an imaging mode. The interface complies with version 2 of the Simple Imaging Access Protocol (SIAP), under development by the International Virtual Observatory Alliance (IVOA), which defines a standard mechanism for discovering images through spatial queries. The heart of the KOA service is an R-tree-based, database-indexing mechanism prototyped by the Virtual Astronomical Observatory (VAO) and further developed by the Montage Image Mosaic project, designed to provide fast access to large imaging data sets as a first step in creating wide-area image mosaics (such as mosaics of subsets of the 4.7 million images of the SDSS DR9 release). The KOA service uses the results of the spatial R-tree search to create an SQLite data database for further relational filtering. The service uses a JSON configuration file to describe the association between instrument parameters and the service query parameters, and to make it applicable beyond the Keck instruments. The images generated at the Keck telescope usually do not encode the image footprints as WCS fields in the FITS file headers. Because SIAP searches are spatial, much of the effort in developing the program interface involved processing the instrument and telescope parameters to understand how accurately we can derive the WCS information for each instrument. This knowledge is now being fed back into the KOA databases as part of a program to include complete metadata information for all imaging observations. The R-tree program was itself extended to support temporal (in addition to spatial) indexing, in response to requests from the planetary science community for a search engine to discover observations of Solar System objects. With this 3D-indexing scheme, the service performs very fast time and spatial matches between the target ephemerides, obtained from the JPL SPICE service. Our experiments indicate these matches can be more than 100 times faster than when separating temporal and spatial searches. Images of the tracks of the moving targets, overlaid with the image footprints, are computed with a new command-line visualization tool, mViewer, released with the Montage distribution. The service is currently in test and will be released in late summer 2016