A new insight into mechanisms of age-related changes in heart rate

Changes in cardiac rhythm induced by blockade of hyperpolarization currents with ZD 7288 depend on animal's age. The increase in cardiointerval duration is related to prolongation of T-P segment on ECG. It is hypothesized that the age-related changes in activity of hyperpolarization channels are determined by a modulating effect of the autonomic nervous system

Age-related peculiarities of heart rate in intact and sympathectomized rats injected with atropine

Atropine induced various changes in the heart rate in intact rats of various ages. In sympathectomized animals, changes in heart rate variability were less pronounced. Atropine blocked the inhibition of cardiac activity induced by electrical stimulation of the vagus nerve

Regulation of cardiac function in prepubertal rats

Prepubertal period in rats is characterized by some peculiarities of the cardiac regulatory mechanisms. In 6-week-old rats atropine produced bradycardia instead of tachycardia. Similar reaction was not observed in chemically sympathectomized age-matched rats

Age-specific vagus regulation of the chronotropic function of the heart in desympathized and intact rats

Comparison of the effects of stimulation of vagus nerves in intact and desympathized rats showed differences in the variation pulsogram parameters in different age groups. A similar time course of variation pulsogram parameters in response to vagus nerve stimulation was observed in normal and experimental rats. © 1997 Plenum Publishing Corporation

Blockade of hyperpolarizing currents produces a dose-dependent effect on heart rate

Intravenous injection of ZD 7288, a new specific hyperpolarizing current blocker, dose-dependently reduces heart rate in adult rats. The autonomic nervous system modulates changes in heart rate caused by hyperpolarizing currents

Indicators of trace-element status of children living in rural areas

The content of essential and toxic elements, except beryllium and mercury, in the hair of examined children (girls aged 7-9 years) is within the biologically acceptable levels set by WHO. The data on the content of essential trace elements suggest that urgent measures aimed at normalization of the elemental status of children are required. © 2011 Springer Science+Business Media, Inc

Изменения гемоциркуляторных и респираторных функций при бронхиальной астме у детей

One hundred and fifty bronchial asthma patients aged 6 to 14 yrs were complexly examined for haemodynamic parameters in correlation with the lung function and the diaphragm activity in different stages of the disease. The respiratory dysfunction based on the bronchial obstruction, irregular lung ventilation and reduction in the diaphragm functional activity was shown to be accompanied by changes in the regional and central blood circulation. A consistency of these disorders depended on the basic therapyУ 150 больных бронхиальной астмой в возрасте от 6 до 14 лет проведено комплексное исследование параметров гемодинамики во взаимосвязи с оценкой функции внешнего дыхания и активности диафрагмы в различные периоды заболевания. Показано, что респираторная дисфункция, в основе которой лежат бронхиальная обструкция, неравномерная вентиляция легких и снижение функциональной активности диафрагмы, сочетается с изменениями регионарной и центральной гемоциркуляции. Причем стойкость отмеченных отклонений зависит от применения базисной терапии

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

: Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10(-11)) in 4,380 cases and 310,238 controls. This locus is near the FLT1 gene encoding Fms-like tyrosine kinase 1, providing biological support, as a placental isoform of this protein (sFlt-1) is implicated in the pathology of preeclampsia. The association was strongest in offspring from pregnancies in which preeclampsia developed during late gestation and offspring birth weights exceeded the tenth centile. An additional nearby variant, rs12050029, associated with preeclampsia independently of rs4769613. The newly discovered locus may enhance understanding of the pathophysiology of preeclampsia and its subtypes.<br/

A new insight into mechanisms of age-related changes in heart rate

Changes in cardiac rhythm induced by blockade of hyperpolarization currents with ZD 7288 depend on animal's age. The increase in cardiointerval duration is related to prolongation of T-P segment on ECG. It is hypothesized that the age-related changes in activity of hyperpolarization channels are determined by a modulating effect of the autonomic nervous system

Age-related peculiarities of heart rate in intact and sympathectomized rats injected with atropine

Atropine induced various changes in the heart rate in intact rats of various ages. In sympathectomized animals, changes in heart rate variability were less pronounced. Atropine blocked the inhibition of cardiac activity induced by electrical stimulation of the vagus nerve