Probing Elemental Abundances in SNR 1987A Using XMM-Newton

We report on the latest (2007 Jan) observations of supernova remnant (SNR) 1987A from the XMM-Newton mission. Since the 2003 May observations of Haberl et al. (2006), 11 emission lines have experienced increases in flux by factors ~ 3 to 10, with the 775 eV line of O VIII showing the greatest increase; we have observed 6 lines of Fe XVII and Fe XVIII previously unreported by XMM-Newton. A two-shock model representing plasmas in non-equilibrium ionization is fitted to the EPIC-pn spectra, yielding temperatures of ~ 0.4 and ~ 3 keV, as well as elemental abundances for N, O, Ne, Mg, Si, S and Fe. We demonstrate that the abundance ratio of N and O can be constrained to less than ~20% accuracy. Within the same confidence interval, the same analysis suggests that the C+N+O abundance varies from ~ 1.1 to 1.4 X 10^-4. Normalizing our obtained abundances by the Large Magellanic Cloud (LMC) values of Hughes, Hayashi & Koyama (1998), we find that O, Ne, Mg and Fe are under-abundant, while Si and S are over-abundant, consistent with the findings of Aschenbach (2007). Such a result has implications for both the single-star and binary accretion/merger models for the progenitor of SNR 1987A. In the context of the binary merger scenario proposed by Morris & Podsiadlowski (2006, 2007), material forming the inner, equatorial ring was expelled after the merger, implying that either our derived Fe abundance is inconsistent with typical LMC values or that iron is under-abundant at the site of the progenitor star of SNR 1987A.Comment: 14 pages, 10 diagrams (2 omitted). Accepted by Ap

Dynamic concentration of motors in microtubule arrays

We present experimental and theoretical studies of the dynamics of molecular motors in microtubule arrays and asters. By solving a convection-diffusion equation we find that the density profile of motors in a two-dimensional aster is characterized by continuously varying exponents. Simulations are used to verify the assumptions of the continuum model. We observe the concentration profiles of kinesin moving in quasi two-dimensional artificial asters by fluorescent microscopy and compare with our theoretical results.Comment: 4pages, 4 figures revte

Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover.

Desmosomes are prominent adhesive junctions present between many epithelial cells as well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling in epithelial and cardiac tissue are poorly understood. We recently identified protein palmitoylation as a mechanism regulating desmosome dynamics. In this study, we have focused on the palmitoylation of the desmosomal cadherin desmoglein-2 (Dsg2) and characterized the role that palmitoylation of Dsg2 plays in its localization and stability in cultured cells. We identified two cysteine residues in the juxtamembrane (intracellular anchor) domain of Dsg2 that, when mutated, eliminate its palmitoylation. These cysteine residues are conserved in all four desmoglein family members. Although mutant Dsg2 localizes to endogenous desmosomes, there is a significant delay in its incorporation into junctions, and the mutant is also present in a cytoplasmic pool. Triton X-100 solubility assays demonstrate that mutant Dsg2 is more soluble than wild-type protein. Interestingly, trafficking of the mutant Dsg2 to the cell surface was delayed, and a pool of the non-palmitoylated Dsg2 co-localized with lysosomal markers. Taken together, these data suggest that palmitoylation of Dsg2 regulates protein transport to the plasma membrane. Modulation of the palmitoylation status of desmosomal cadherins can affect desmosome dynamics

Revised physical elements of the astrophysically important O9.5+O9.5V eclipsing binary system Y Cyg

Thanks to its long and rich observational history and rapid apsidal motion, the massive eclipsing binary Y Cyg represents one of the cornestones to critical tests of stellar evolution theory for massive stars. Yet, the determination of the basic physical properties is less accurate than it could be given the existing number of spectral and photometric observations. Our goal is to analyze all these data simultaneously with the new dedicated series of our own spectral and photometric observations from observatories widely separated in longitude. We obtained new series of UBV observations at three observatories separated in local time to obtain complete light curves of Y Cyg for its orbital period close to 3 days. This new photometry was reduced and carefully transformed to the standard UBV system using the HEC22 program. We also obtained new series of red spectra secured at two observatories and re-analyzed earlier obtained blue electronic spectra. Our analyses provide the most accurate so far published value of the apsidal period of 47.805 +/- 0.030 yrs and the following physical elements: M1=17.72+/-0.35$ Msun, M2=17.73+/-0.30 Msun, R1=5.785+/-0.091 Rsun, and R2=5.816+/-0.063 Rsun. The disentangling thus resulted in the masses, which are somewhat higher than all previous determinations and virtually the same for both stars, while the light curve implies a slighly higher radius and luminosity for star 2. The above empirical values imply the logarithm of the internal structure constant log k2 = -1.937. A comparison with Claret's stellar interior models implies an age close to 2 millions yrs for both stars. The claimed accuracy of modern element determination of 1-2 per cent seems still a bit too optimistic and obtaining new high-dispersion and high-resolution spectra is desirable.Comment: 13 pages; accepted for publication in Astronomy and Astrophysic

Development of a Long-Term (1884-2006) Serially Complete Dataset of U.S. Temperatures and Precipitation for Climate Services

Serially complete climate datasets with no missing data are necessary for a diverse group of users working in many economic sectors. In this article we describe the procedures used to create a Serially Complete Data set (SCD) for the U.S. We include the selection criterion applied to potential SCD stations, the various procedural steps and the details applied to each step. A few observations that were not previously digitized were obtained from observers official paper reports. The methods used to estimate missing data are the Spatial Regression Test and the Inverse Distance Weighting technique. Using the criterion for selecting stations we were able to include 2144 stations for the SCD that had at least 1 element (maximum/minimum temperature and/or precipitation) for a continuous period of at least 40 years. In addition, the quality control procedure assigned confidence intervals to all observations and many of the estimates. We continue to explore the options for estimating any missing data that remain after our 3 step approach and we look forward to changing the base data set form TD 3200 to GHCN

Understanding Mechanochemical Coupling in Kinesins Using First-Passage Time Processes

Kinesins are processive motor proteins that move along microtubules in a stepwise manner, and their motion is powered by the hydrolysis of ATP. Recent experiments have investigated the coupling between the individual steps of single kinesin molecules and ATP hydrolysis, taking explicitly into account forward steps, backward steps and detachments. A theoretical study of mechanochemical coupling in kinesins, which extends the approach used successfully to describe the dynamics of conventional motor proteins, is presented. The possibility of irreversible detachments of kinesins from the microtubules is also explicitly taken into account. Using the method of first- passage times, experimental data on the mechanochemical coupling in kinesins are fully described using the simplest two-state model. It is shown that the dwell times for the kinesin to move one step forward or backward, or to dissociate irreversibly are the same, although the probabilities of these events are different. It is concluded that the current theoretical view, that only the forward motion of the motor protein molecule is coupled to ATP hydrolysis, is consistent with all available experimental observations for kinesins.Comment: Submitted to Biophysical Journa

The key role of smooth impurity potential in formation of hole spectrum for p-Ge/Ge_{1-x}Si_x heterostructures in the quantum Hall regime

We have measured the temperature (0.1 <= T <= 15 K) and magnetic field (0 <= B <= 12 T) dependences of longitudinal and Hall resistivities for the p-Ge_0.93Si_0.07/Ge multilayers with different Ge layer widths 10 <= d_w <= 38 nm and hole densities p_s = (1-5)10^11 cm^-2. Two models for the long-range random impurity potential (the model with randomly distributed charged centers located outside the conducting layer and the model of the system with a spacer) are used for evaluation of the impurity potential fluctuation characteristics: the random potential amplitude, nonlinear screening length in vicinity of integer filling factors nu = 1 and nu = 2 and the background density of state (DOS). The described models are suitable for explanation of the unusually high value of DOS at nu = 1 and nu = 2, in contrast to the short-range impurity potential models. For half-integer filling factors the linear temperature dependence of the effective QHE plateau-to-plateau transition width nu_0(T) is observed in contrast to scaling behavior for systems with short-range disorder. The finite T -> 0 width of QHE transitions may be due to an effective low temperature screening of smooth random potential owing to Coulomb repulsion of electrons.Comment: Accepted for publication in Nanotechnolog