Hypereutectic al-ca-mn-(Ni) alloys as natural eutectic composites

Data Availability Statement: Data are available from the corresponding author on reasonable request.In the present paper, Natural Metal-Matrix Composites (NMMC) based on multicomponent hypereutectic Al-Ca-(Mn)-(Ni) alloys were studied in as-cast, annealed and rolled conditions. Thermo-Calc software and microstructural observations were utilised for analysing the equilibrium and actual phase composition of the alloys including correction of the Al-Ca-Mn system liquidus projection and the solid phase distribution in the Al-Ca-Mn-Ni system. A previously unknown Al10CaMn2 was discovered by both electron microprobe analysis and X-ray studies. The Al-6Ca-3Mn, Al-8Ca-2Mn, Al-8Ca-2Mn-1Ni alloys with representative NMMC structure included ultrafine Ca-rich eutectic and various small-sized primary crystals were found to have excellent feasibility of rolling as compared to its hypereutectic Al-Si counterpart. What is more, Al-Ca alloys showed comparable Coefficient of Thermal Expansion values due to enormous volume fraction of Al-based eutectic and primary intermetallics. Analysis of tensile samples’ fracture surfaces revealed that primary intermetallics may act either as stress raisers or malleable particles depending on their stiffness under deformation. It is shown that a compact morphology can be achieved by conventional casting without using any refining agents. Novel hypereutectic Al-Ca NMMC materials solidifying with the formation of Al10Mn2Ca primary compound have the best ductility and strength. We reasonably propose these materials for high-load pistons.Russian Science Foundation (project no. 20–19–00746)

Imbalance in the oxidative stress system-antioxidant protection in patients with chronic pyelonephritis depending on the course of the diseas

Assessment of the imbalance in the system of oxidative stress - antioxidant protection in patients with chronic pyelonephritis depending on the course of the diseas

Assessing cytokine status of patients with chronic endometritis combined with endometrial hyperplastic processes in reproductive period

The goal of our study was to examine local and serum cytokine level involved in regulating inflammation in patients with chronic endometritis combined with endometrial hyperplastic processes. On admission, all patients underwent hysteroscopy with separate diagnostic curettage followed by histological examination of samples isolated from the uterine and cervical canal mucosa. Such manipulations were indicated due to abnormal uterine bleeding as well as suspected endometrial pathology based on ultrasound examination. According to the histological examination data of the endometrial samples, all patients were divided into two groups: group I contained 45 women with CE combined with PEG without atypia; group II — 38 patients with morphologically verified CEE combined with AEG without atypia. Level of IL-1P, IL-2, IL-6, IFNy, TNFa in biological fluids (aspirate from the uterus; serum) was measured by using enzyme-linked immunosorbent assay. We found that in both groups (91.1% and 89.6%, respectively) the vast majority of patients was hospitalized due to abnormal uterine bleeding. Oligomenorrhea alternated with intermenstrual bleeding (66.7% and 71.2%, respectively) and dominated in pattern of menstrual cycle disorders in the examined patients, whereas 11 (24.4%) and 7 (18.4%) patients from group I and II, respectively, were noted to suffer from severe menstrual bleeding. Overall, analyzing the data on cytokine level both in the uterine aspirate and serum evidences about ongoing inflammatory process found at examination time point. Upon that, such process was not only local, but also exhibited signs of a systemic inflammatory response. The data on cytokine level in the uterine aspirate from patients with CE coupled to PGE or CGE without atypia point at local inflammatory process characterized by significantly increased concentration of IL-ф, IL-2, IL-6, TNFa and IFNy. At the same time, higher level of IL-ф and IFNy in patients from group II might indicates that degree of morphological changes in the endometrium could affect the level of local cytokine production. Thus, the data obtained evidence that immune changes in chronic endometritis combined with non-atypical endometrial hyperplastic processes mostly occur locally. In this regard, measuring cytokine concentration in the uterine aspirate is a diagnostic predictor and serves as a sign for monitoring therapeutic effectiveness of therapy in this cohort of patients

Investigation on the association of cardiovascular markers with severity of chronic pyelonephritis

Chronic kidney disease (CKD) is an established independent risk factor for cardiovascular disease (CVD) and is caused by chronic pyelonephritis (CP). This study aimed to investigate the effect of the association of cardiovascular markers with the course of CP on the comorbidity of CP with ischemic heart disease. The study participants included 125 patients with CP without symptoms of urinary tract obstruction who were divided into three group

Changes in the adaptive potential and cognitive functions of students under intellectual load

The article deals with the problem of the impact of intellectual load on the cardiorespiratory system, concentration and attention of 3rd-year students of the Burdenko State Medical University during the educational process. In addition, the students were evaluated for indicators that reflect the physical development and functional state of the body. The study involved 31 students of medical and pediatric faculties. Students have a predominance of the activity of the sympathetic nervous system, a decrease in concentration and the body's resistance to hypoxia by the end of the lesson.В статье затрагивается проблема воздействия интеллектуальной нагрузки на кардиореспираторную систему, концентрацию и внимание студентов 3 курса ВГМУ им. Н.Н. Бурденко во время учебного процесса. Помимо этого, у учащихся оценивали показатели, отражающие физическое развитие и функциональное состояние организма. В исследовании приняли участие 31 студент лечебного и педиатрического факультетов. У учащихся отмечается преобладание активности симпатической нервной системы, снижение концентрации внимания и устойчивости организма к гипоксии к концу занятия

Microscopics of meson degrees of freedom in nucleons and mesons in nuclei - what can be seen in the process of quasielastic knockout of mesons by high-energy electrons

Developed earlier concept of quasielastic knock out of pions from nucleons by high-energy electrons is propounded as a tool for checking microscopical model ($^3P_0$ - fluctuation) for decay of N to different channels $\pi+B$ and Preparata model of nucleus structure.Comment: 6 pages, 5 figures, Talk given at 16 Baldin Symposium in June 200

Correlation of expression of topoisomerase 2 alpha and stage by TNM in the breast cancer

In this article, we analyzed the correlation of enzyme topoisomerase 2 alpha and stage by TNM in cells of breast carcinoma at 766 patients who have breast cancer of not-spicific type. All cases were divided into 5 molecularbiological subtypes based on immunohistochemical studies of hormonal receptors. We found medial correlation of distant metastasis (M) and small correlation of low size oy tumor (T) in «triple negative» subtype of breast cancer.В данной работе проведен анализ взаимосвязи между экспрессией фермента топоизомеразы 2 альфа и стадией по TNM в клетках карциномы молочной железы у 766 больных инвазивным раком молочной железы неспецифического типа. Все случаи были разделены на 5 молекулярно- биологических подтипов на основе определения рецепторов к гормонам, HER2/neu, Ki-67 иммуногистохимическим методом. В исследовании, только в «тройном негативном» подтипе обнаружена низкая корреляция между экспрессией TOP2A и T (размером опухоли), и умеренная- с М (отдаленным метастазированием)

Piezo-Responsive Hydrogen-Bonded Frameworks Based on Vanillin-Barbiturate Conjugates

A concept of piezo-responsive hydrogen-bonded π-π-stacked organic frameworks made from Knoevenagel-condensed vanillin–barbiturate conjugates was proposed. Replacement of the substituent at the ether oxygen atom of the vanillin moiety from methyl (compound 3a) to ethyl (compound 3b) changed the appearance of the products from rigid rods to porous structures according to optical microscopy and scanning electron microscopy (SEM), and led to a decrease in the degree of crystallinity of corresponding powders according to X-ray diffractometry (XRD). Quantum chemical calculations of possible dimer models of vanillin–barbiturate conjugates using density functional theory (DFT) revealed that π-π stacking between aryl rings of the vanillin moiety stabilized the dimer to a greater extent than hydrogen bonding between carbonyl oxygen atoms and amide hydrogen atoms. According to piezoresponse force microscopy (PFM), there was a notable decrease in the vertical piezo-coefficient upon transition from rigid rods of compound 3a to irregular-shaped aggregates of compound 3b (average values of d33 coefficient corresponded to 2.74 ± 0.54 pm/V and 0.57 ± 0.11 pm/V), which is comparable to that of lithium niobate (d33 coefficient was 7 pm/V). © 2022 by the authors.2.1.06.03, 20211572; Russian Foundation for Basic Research, РФФИ: 20-53-00043-Bel_a; Ministry of Science and Technology, Taiwan, MOST: 19-52-06004 MNTI_a; Ural Federal University, UrFU: 2968; Ministry of Science and Higher Education of the Russian Federation: 075-15-2021-677The work was supported by the Russian Foundation for Basic Research (RFBR, project no. 20-53-00043-Bel_a) and the PFM measurements were done under RFBR and MOST project no. 19-52-06004 MNTI_a. The equipment of the Ural Center for Shared Use “Modern nanotechnology” Ural Federal University (Reg. No. 2968), which is supported by the Ministry of Science and Higher Education RF (project No. 075-15-2021-677), was used. T.V.S. acknowledges the support from the State Program of Scientific Researchers of Belarus (research issue 2.1.06.03, state registration number: 20211572)