Trepanacija i povećan parijetalni foramen na lubanjama otkrivenima na otočju Loyalty

The goal of this study is a comprehensive examination of openings discovered on two skulls in the collection of skeletal remains from the Loyalty Islands (Melanesia). The skull № 1524 displayed an evidence of successful trepanation, and the skull № 7985 revealed openings that were reminiscent of a trepanation, however, we are inclined to believe that in the latter case we are dealing with a rare genetic anomaly - enlarged parietal foramen.Cilj je ovog istraživanja opsežan pregled otvora otkrivenih na dvjema lubanjama u zbirci skeletnih ostataka s otočja Loyalty (Melanezija). Lubanja br. 1524 dokaz je uspješne trepanacije, a otvori lubanje br. 7985 podsjećaju na trepanaciju, međutim skloni smo vjerovati da se u potonjem slučaju susrećemo s rijetkom genetskom anomalijom – povećanim parijetalnim foramenom

Texts Segmentation and Semantic Comparison: Method and Results of its Application

The paper describes the approach of scientific texts comparing. The approach is characterized by the comparison of significant textual passages that consist of elements of meaning. The proposed method of scientific texts comparison differs from others known methods by the using of segmentation with semantic criteria, taking into account synonyms. That allows to automatically detect the semantic similarity between two compared texts, and take into account both the morphological structure of the text and its lexico-semantic content. The results of practical application of the method are also presented in the paper

THE CEMETERY OF FRONTOVOE 3New data on the culture of the Crimeain the Roman and Early Great Migration periods

International audienc

Precision low-dose brachytherapy of prostate cancer under PSMA-receptor molecular visualization

Brachytherapy with implantation of micro sources based on isotope 125I is a preferred treatment for localized prostate cancer without signs of germination of the gland capsule and in the absence of signs of metastases (stage cT1-T23aN0M0). Structural imaging methods (ultrasound, computed tomography, and magnetic resonance imaging) do not have high specificity in the differential diagnosis of prostate cancer. Hybrid technologies of radiation imaging (single-photon emission computed tomography/computed tomography, positron emission tomography/computed tomography, and positron emission tomography/magnetic resonance imaging) combine the advantages of high sensitivity of cross-sectional structural imaging methods (computed tomography and magnetic resonance imaging) and high specificity of molecular imaging methods (single-photon emission computed tomography and positron emission tomography) with tumorotropic radiopharmaceuticals. In this original clinical study, based on seven observations of localized prostate cancer (Gleason 6–7), it was shown that the precision of low-dose brachytherapy using 125I micro sources of localized prostate carcinomas, along with targeted biopsy, can be increased using hybrid methods of PSMA-receptor molecular imaging (single-photon emission computed tomography/ computed tomography, positron emission tomography/ computed tomography). The single-photon emission computed tomography/ computed tomography method is more accessible than positron emission tomography/ computed tomography. Moreover, when coupled with cold kits (HYNIC-PSMA), it allows research within any radioisotope diagnostics laboratory equipped with single-photon emission computed tomography/ computed tomography. The innovative technology of PSMA-navigation biopsy and brachytherapy, under the control of hybrid molecular imaging, can be used in primary and recurrent cases of localized prostate cancer, increases the accuracy and reduces the traumatic nature of procedures, and increases the medical and economic efficiency of low-dose brachytherapy with 125I micro sources. Further research is needed to improve the technology and evaluate its long-term results

One-pot four-component reaction for the generation of pyrazoles and pyrimidines

The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot proces