9 research outputs found

    CREATED OF AN INTEGRATED QUALITY SYSTEM FOR THE PRODUCTION OF CANNED MEAT FOR CHILD NUTRITION

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    The development of an integrated safety and quality system at enterprises for the production of baby food includes measures  thataimed at analyzing risks and identifying critical control points throughout the process. The article presents studies on the identification and analysis of hazards and assessing the severity of the consequences of their manifestation. In order to integrate, the international standards ISO 9001 and ISO 22000 were selected, on the basis of which the quality system processes were identified, the resources and requirements for them were determined, as well as the parameters for monitoring these processes, the criteria for evaluating the effectiveness and efficiency of the developed system were established. Within the framework of the integrated system, the main and interior processes were identified. The main processes include organization management processes, planning and implementation processes for safe and quality products, and processes for monitoring, analysis and improvement. Support processes include processes for managing the organization’s personnel, its infrastructure and production environment, as well as processes for managing documentation and records of the system

    Ρ„ΠœΠ Π’-исслСдованиС особСнностСй Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ активности ΠΌΠΎΠ·Π³Π° ΠΏΡ€ΠΈ ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ»ΡŒΠ½ΠΎΠΌ ΠΏΠ΅Ρ€Π΅ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠΈ внимания Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Ρ€Π΅Ρ‡Π΅Π²Ρ‹ΠΌΠΈ расстройствами

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    The aim: to examine characteristics of functional brain activity in task switching in patients with speech disorders after brain damages and to examine of functional cerebral reorganization after course of rehabilitation. Materials and methods. There were 45 participants which were divided into two groups: 25 (55.6%) healthy people and 20 (44.4%) patients with different forms of aphasia and/or dysarthria. MRI and fMRI methods were used. In the fMRI task, the participants had to shift their attention between two objectives (classifying figures according to their form or number). Results. The results of the second session in the group of healthy individuals showed no significant changes in the brain activity as compared to the first session. In patients three patterns of activation were found: a powerful asymmetric activation in the frontal and parietal lobe in one hemisphere as compared to the other one (20% of patients); a very low activation mainly in frontal areas (40% of patients); and a very high and mostly diffuse brain activation (40% of patients). The second fMRI session revealed that patients with positive dynamics of recovery of higher mental functions showed that their brain activations are closer to average levels of those shown by healthy individuals (of the same sex and age). This was mainly expressed in frontal areas. Also it was found that activation in additional brain areas was lower or altogether absent which wasn't observed in healthy individuals. Conclusion. The results of this study support the view about the reliability of repeating the same fMRI task after a period of time, and allow to use this method for assessment of rehabilitation programs in patients with cerebral pathology as well as show the tendency to normalization of functional brain activity in patients with positive dynamics of recovery.ЦСль исслСдования: ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ особСнностСй Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ активности ΠΌΠΎΠ·Π³Π° ΠΏΡ€ΠΈ ΠΏΠ΅Ρ€Π΅ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠΈ внимания ΠΌΠ΅ΠΆΠ΄Ρƒ Π·Π°Π΄Π°Ρ‡Π°ΠΌΠΈ Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с Ρ€Π΅Ρ‡Π΅Π²Ρ‹ΠΌΠΈ Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΡΠΌΠΈ послС Π»ΠΎΠΊΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΏΠΎΡ€Π°ΠΆΠ΅Π½ΠΈΠΉ ΠΌΠΎΠ·Π³Π° ΠΈ ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ активности ΠΌΠΎΠ·Π³Π° послС курса Ρ€Π΅Π°Π±ΠΈΠ»ΠΈΡ‚Π°Ρ†ΠΈΠΈ. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ исслСдовании приняли участиС 45 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… Ρ€Π°Π·Π΄Π΅Π»ΠΈΠ»ΠΈ Π½Π° 2 Π³Ρ€ΡƒΠΏΠΏΡ‹: 25 (55,6%) Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… испытуСмых ΠΈ 20 (44,4%) ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² исслСдуСмой Π³Ρ€ΡƒΠΏΠΏΡ‹ с Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌΠΈ Ρ„ΠΎΡ€ΠΌΠ°ΠΌΠΈ Π°Ρ„Π°Π·ΠΈΠΉ ΠΈ/ΠΈΠ»ΠΈ Π΄ΠΈΠ·Π°Ρ€Ρ‚Ρ€ΠΈΠΉ. ВсСм испытуСмым ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ МРВ ΠΈ Ρ„ΠœΠ Π’-исслСдованиС. Π’ Ρ„ΠœΠ Π’-исслСдовании испытуСмыС выполняли Π·Π°Π΄Π°Ρ‡Ρƒ, Π² ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠΉ Π½ΡƒΠΆΠ½ΠΎ Π±Ρ‹Π»ΠΎ ΠΏΠ΅Ρ€Π΅ΠΊΠ»ΡŽΡ‡Π°Ρ‚ΡŒ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄Ρƒ двумя Π·Π°Π΄Π°Ρ‡Π°ΠΌΠΈ (ΡΠΎΡ€Ρ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Ρ„ΠΈΠ³ΡƒΡ€Ρ‹ ΠΏΠΎ Ρ„ΠΎΡ€ΠΌΠ΅ ΠΈΠ»ΠΈ ΠΏΠΎ количСству). Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠŸΡ€ΠΈ ΠΏΠΎΠ²Ρ‚ΠΎΡ€Π½ΠΎΠΌ исслСдовании Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… испытуСмых Π½Π΅ Π±Ρ‹Π»ΠΎ ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½ΠΎ ΠΊΠ°ΠΊΠΈΡ…-Π»ΠΈΠ±ΠΎ Π·Π½Π°Ρ‡ΠΈΠΌΡ‹Ρ… ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ активности ΠΌΠΎΠ·Π³Π° ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с ΠΏΠ΅Ρ€Π²Ρ‹ΠΌ исслСдованиСм. Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Π±Ρ‹Π»ΠΎ выявлСно 3 ΠΏΠ°Ρ‚Ρ‚Π΅Ρ€Π½Π° Π°ΠΊΡ‚ΠΈΠ²Π°Ρ†ΠΈΠΈ ΠΏΡ€ΠΈ Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ Π΄Π°Π½Π½ΠΎΠΉ Π·Π°Π΄Π°Ρ‡ΠΈ: ярко выраТСнная асиммСтричная активация Π² Π»ΠΎΠ±Π½Ρ‹Ρ… ΠΈ Ρ‚Π΅ΠΌΠ΅Π½Π½Ρ‹Ρ… областях Π² ΠΎΠ΄Π½ΠΎΠΌ ΠΈΠ· ΠΏΠΎΠ»ΡƒΡˆΠ°Ρ€ΠΈΠΉ ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с Π΄Ρ€ΡƒΠ³ΠΈΠΌ (20% ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ²); ΠΎΡ‡Π΅Π½ΡŒ низкая активация Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°, прСимущСствСнно Π² Π»ΠΎΠ±Π½Ρ‹Ρ… ΠΎΡ‚Π΄Π΅Π»Π°Ρ… (40% ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ²); ΠΎΡ‡Π΅Π½ΡŒ высокая, часто диффузная активация Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° (40% ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ²). ΠŸΡ€ΠΈ ΠΏΠΎΠ²Ρ‚ΠΎΡ€Π½ΠΎΠΌ Ρ„ΠœΠ Π’-обслСдовании ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΎΠΉ восстановлСния Π²Ρ‹ΡΡˆΠΈΡ… психичСских Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΉ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ активности ΠΌΠΎΠ·Π³Π° ΠΏΡ€ΠΈΠ±Π»ΠΈΠΆΠ°Π»ΠΈΡΡŒ ΠΊ срСдним показатСлям Π³Ρ€ΡƒΠΏΠΏΡ‹ Π½ΠΎΡ€ΠΌΡ‹ (ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰Π΅Π³ΠΎ ΠΏΠΎΠ»Π° ΠΈ возраста). Π­Ρ‚ΠΎ Π±Ρ‹Π»ΠΎ Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½ΠΎ прСимущСствСнно Π² Π»ΠΎΠ±Π½Ρ‹Ρ… областях, Ρ‚Π°ΠΊΠΆΠ΅ ΠΎΡ‚ΠΌΠ΅Ρ‡Π°Π»ΠΎΡΡŒ сниТСниС ΠΈΠ»ΠΈ исчСзновСниС Π°ΠΊΡ‚ΠΈΠ²Π°Ρ†ΠΈΠΈ Π² Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… областях Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°, Π½Π΅ наблюдаСмой Ρƒ Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… людСй. Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ настоящСго исслСдования ΠΏΠΎΠ΄Π΄Π΅Ρ€ΠΆΠΈΠ²Π°ΡŽΡ‚ Ρ‚ΠΎΡ‡ΠΊΡƒ зрСния ΠΎ надСТности ΠΏΠΎΠ²Ρ‚ΠΎΡ€Π½ΠΎΠ³ΠΎ Ρ„ΠœΠ Π’-исслСдования, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‚ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚ΡŒ Π΄Π°Π½Π½Ρ‹ΠΉ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ для ΠΎΡ†Π΅Π½ΠΊΠΈ воздСйствия Ρ€Π΅Π°Π±ΠΈΠ»ΠΈΡ‚Π°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌ Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Ρ†Π΅Ρ€Π΅Π±Ρ€Π°Π»ΡŒΠ½ΠΎΠΉ ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΏΠΎΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‚, Ρ‡Ρ‚ΠΎ Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΎΠΉ восстановлСния Π½Π°Π±Π»ΡŽΠ΄Π°Π΅Ρ‚ΡΡ тСндСнция ΠΊ Π½ΠΎΡ€ΠΌΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ активности ΠΌΠΎΠ·Π³Π°

    Measuring working memory in aphasia: Comparing performance on complex span and N-back tasks

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    Introduction Deficits in working memory (WM) are amongst the most widely acknowledged cognitive impairments in aphasia.However, there is still on-going debate what tasks should be used to assess WM in aphasia (Wright & Fergadiotos, 2012). The two main alternatives for this purpose are simplified complex span tasks and N-back tasks. In a typical complex span task, a processing task (e.g., sentence reading), is given along with a set of stimuli (e.g., words) to be remembered for later recall. In N-back tasks, participants are instructed to judge whether an item matches a previous one presented n items before. Proponents of complex span tasks state that these tasks are the gold standard for assessing WM capacity in cognitive psychology and that variations of these tasksare endorsed as valid means of indexing WM capacity within different theoretical frameworks. On the other hand, researchers using N-back tasks state that since these tasks are more language-free in nature, they are more appropriate for indexing cognitive non-linguistic abilities with language-impaired populations. Several investigations comparing the two tasks in healthy controls have demonstrated no relationship between the two tasks (Jaeggi et al., 2010; Kane et al., 2007). Although, limited conflicting findings indicating a significant relationship between the two tasks have also been reported (Schmiedek et al., 2009). Additionally, performance on complex span task in aphasia studies have repeatedly been related to performance on standardized language tests (Sung et al. 2009; Wright & Fergadiotos, 2012), while similar correlations have never found for N-back tasks (Christensen, & Wright, 2010; Mayer & Murray, 2012). The aim of the present study was to directly investigate the relationship between performance on complex span tasks and N-back tasks in aphasia. Methods 32native speakers of Russian with aphasia following left hemisphere stroke participated. Complex span task (modified listening span task, Ivanova & Hallowell, 2014), 2-back and 0-back tasks with words, a test of auditory language comprehension– Quantitative Assessment of Speech in Aphasia (QASA; Tsvetkova et al., 1981) – were administered. Results and discussion No significant correlations were observed between performance on complex span task and N-back tasks.Furthermore, performance on the modified listening span was related to performance on the comprehension subtest of the QASA, while no relationship was found for 2-back and 0-back tasks.Our results mirror studies in healthy controls that demonstrated no relationship between performance on the two tasks(Jaeggi et al., 2010; Kane et al., 2007). Thus although N-back tasks seem similar to traditional complex span measures and may also index abilities related to cognitive processing, the evidence to date does not warrant their direct association with the construct of WM. Implications for future investigation of cognitive deficits in aphasia will be discussed

    Created of an integrated quality system for the production of canned meat for child nutrition

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    The development of an integrated safety and quality system at enterprises for the production of baby food includes measures thataimed at analyzing risks and identifying critical control points throughout the process. The article presents studies on the identification and analysis of hazards and assessing the severity of the consequences of their manifestation. In order to integrate, the international standards ISO 9001 and ISO 22000 were selected, on the basis of which the quality system processes were identified, the resources and requirements for them were determined, as well as the parameters for monitoring these processes, the criteria for evaluating the effectiveness and efficiency of the developed system were established. Within the framework of the integrated system, the main and interior processes were identified. The main processes include organization management processes, planning and implementation processes for safe and quality products, and processes for monitoring, analysis and improvement. Support processes include processes for managing the organization’s personnel, its infrastructure and production environment, as well as processes for managing documentation and records of the system

    Risk analysis within the production process of fish preserves

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    One of the primary tasks for today is the production of high quality and safe products according to the legislation of Russian Federation. There are a number of risks within the production process. The common problem is the heat treatment process. This problem is for fish preserves. Such products can classify as perishable. It is necessary to carefully approach the choice of raw materials and compliance with all technological regimes. Since there is always the possibility of various dangers. In order to minimize dangerous factors, it is important to use a quality method with identifying the most important of them for factors matrix for production process of fish preserves proposed to develop a diagram of quality and safety indicators and identify the most important of them for further use to form a matrix of technological factors that have a direct impact on quality and safety indicators in the production of fish preserves

    Cell-Molecular Interactions of Nano- and Microparticles in Dental Implantology

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    The role of metallic nano- and microparticles in the development of inflammation has not yet been investigated. Soft tissue biopsy specimens of the bone bed taken during surgical revisions, as well as supernatants obtained from the surface of the orthopedic structures and dental implants (control), were examined. Investigations were performed using X-ray microtomography, X-ray fluorescence analysis, and scanning electron microscopy. Histological studies of the bone bed tissues were performed. Nanoscale and microscale metallic particles were identified as participants in the inflammatory process in tissues. Supernatants containing nanoscale particles were obtained from the surfaces of 20 units of new dental implants. Early and late apoptosis and necrosis of immunocompetent cells after co-culture and induction by lipopolysaccharide and human venous blood serum were studied in an experiment with staging on the THP-1 (human monocytic) cell line using visualizing cytometry. As a result, it was found that nano- and microparticles emitted from the surface of the oxide layer of medical devices impregnated soft tissue biopsy specimens. By using different methods to analyze the cell–molecule interactions of nano- and microparticles both from a clinical perspective and an experimental research perspective, the possibility of forming a chronic immunopathological endogenous inflammatory process with an autoimmune component in the tissues was revealed

    Cell-Molecular Interactions of Nano- and Microparticles in Dental Implantology

    No full text
    The role of metallic nano- and microparticles in the development of inflammation has not yet been investigated. Soft tissue biopsy specimens of the bone bed taken during surgical revisions, as well as supernatants obtained from the surface of the orthopedic structures and dental implants (control), were examined. Investigations were performed using X-ray microtomography, X-ray fluorescence analysis, and scanning electron microscopy. Histological studies of the bone bed tissues were performed. Nanoscale and microscale metallic particles were identified as participants in the inflammatory process in tissues. Supernatants containing nanoscale particles were obtained from the surfaces of 20 units of new dental implants. Early and late apoptosis and necrosis of immunocompetent cells after co-culture and induction by lipopolysaccharide and human venous blood serum were studied in an experiment with staging on the THP-1 (human monocytic) cell line using visualizing cytometry. As a result, it was found that nano- and microparticles emitted from the surface of the oxide layer of medical devices impregnated soft tissue biopsy specimens. By using different methods to analyze the cell–molecule interactions of nano- and microparticles both from a clinical perspective and an experimental research perspective, the possibility of forming a chronic immunopathological endogenous inflammatory process with an autoimmune component in the tissues was revealed
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