21 research outputs found
ΠΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠΈ ΠΠ΅Π»Π°ΡΡΡΡ ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΈΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ ΠΊ Π¨ΠΠ‘: ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ
In the era of globalization, integration groupings have become an important tool for the development of many countries in the world economy. They contribute to the formation of close economic ties and coordination of foreign trade between the participants, which in turn has a favorable effect on the development of the national economy of the country. Participation in integration associations is of great importance for the development of Belarusβ economy and increasing its role in the international arena. Membership in the SCO opens up new prospects for the country and provides an opportunity to expand cooperation with other countries of the Asian region. Once Belarus becomes a full-fledged member of the association, the country will have new ways to develop its potential in various areas, including the economy, logistics, transport, security, culture, education, healthcare, tourism, industrial and agricultural sector, science, as well as experience in international multilateral cooperation. The article is devoted to the topic of assessing the potential of joining the Shanghai Cooperation Organization integration association of the Republic of Belarus. In order to assess the prospects of economic cooperation more accurately, the authors conducted an econometric analysis using a modified version of the traditional gravity model of Belarusβ foreign trade with the member countries. As a result, the authors have identified the most significant factors influencing the volume of trade with the member countries. By analyzing the ratio of calculated indicators to the actual level of exports and imports, the authors made a conclusion about the level of realization of trade potential with the SCO countries. As a consequence, the authors proposed possible ways to implement trade by analyzing the commodity structure of foreign trade flows of the Republic of Belarus with the members of the integration association.Π ΡΠΏΠΎΡ
Ρ Π³Π»ΠΎΠ±Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ Π³ΡΡΠΏΠΏΠΈΡΠΎΠ²ΠΊΠΈ ΡΡΠ°Π»ΠΈ Π²Π°ΠΆΠ½ΡΠΌ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠΌ Π΄Π»Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π° ΡΡΡΠ°Π½ Π² ΠΌΠΈΡΠΎΠ²ΠΎΠΌ Ρ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅. ΠΠ½ΠΈ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅ΡΠ½ΡΡ
ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΡΠ·Π΅ΠΉ ΠΈ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½Π°ΡΠΈΠΈ Π²Π½Π΅ΡΠ½Π΅ΠΉ ΡΠΎΡΠ³ΠΎΠ²Π»ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠ°ΡΡΠ½ΠΈΠΊΠ°ΠΌΠΈ, ΡΡΠΎ, Π² ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ, Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎ ΡΠΊΠ°Π·ΡΠ²Π°Π΅ΡΡΡ Π½Π° ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΠΊΠΈ ΡΡΡΠ°Π½Ρ. Π£ΡΠ°ΡΡΠΈΠ΅ Π² ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΠ±ΡΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡΡ
ΠΈΠΌΠ΅Π΅Ρ Π±ΠΎΠ»ΡΡΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π΄Π»Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΠΊΠΈ ΠΠ΅Π»Π°ΡΡΡΠΈ ΠΈ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ Π΅Π΅ ΡΠΎΠ»ΠΈ Π½Π° ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠΉ Π°ΡΠ΅Π½Π΅. ΠΡΡΡΠΏΠ»Π΅Π½ΠΈΠ΅ Π² Π¨ΠΠ‘ ΠΎΡΠΊΡΡΠ²Π°Π΅Ρ Π½ΠΎΠ²ΡΠ΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ Π΄Π»Ρ ΡΡΡΠ°Π½Ρ ΠΈ Π΄Π°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΠ°ΡΡΠΈΡΡΡΡ ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΡ Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΡΡΡΠ°Π½Π°ΠΌΠΈ ΠΠ·ΠΈΠ°ΡΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π³ΠΈΠΎΠ½Π°. ΠΠΎΡΠ»Π΅ ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΠ΅Π»Π°ΡΡΡΠΈ ΠΏΠΎΠ»Π½ΠΎΠΏΡΠ°Π²Π½ΡΠΌ ΡΡΠ°ΡΡΠ½ΠΈΠΊΠΎΠΌ ΠΎΠ±ΡΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ ΠΏΠ΅ΡΠ΅Π΄ ΡΡΡΠ°Π½ΠΎΠΉ ΠΎΡΠΊΡΠΎΡΡΡΡ Π½ΠΎΠ²ΡΠ΅ ΠΏΡΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΡΠ΅ΡΠ°Ρ
, Π²ΠΊΠ»ΡΡΠ°Ρ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΠΊΡ, Π»ΠΎΠ³ΠΈΡΡΠΈΠΊΡ, ΡΡΠ°Π½ΡΠΏΠΎΡΡ, Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ, ΠΊΡΠ»ΡΡΡΡΡ, ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅, Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠ΅, ΡΡΡΠΈΠ·ΠΌ, ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΡΠΉ ΠΈ ΡΠ΅Π»ΡΡΠΊΠΎΡ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅Π½Π½ΡΠΉ ΡΠ΅ΠΊΡΠΎΡ, Π½Π°ΡΠΊΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΡΡ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΌΠ½ΠΎΠ³ΠΎΡΡΠΎΡΠΎΠ½Π½Π΅Π³ΠΎ ΡΠΎΡΡΡΠ΄Π½ΠΈΡΠ΅ΡΡΠ²Π°. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΡΠ²ΡΡΠ΅Π½ΠΎ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° Π²ΡΡΡΠΏΠ»Π΅Π½ΠΈΡ Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠΈ ΠΠ΅Π»Π°ΡΡΡΡ Π² ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΠΎΠ±ΡΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ Π¨Π°Π½Ρ
Π°ΠΉΡΠΊΠΎΠΉ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ ΡΠΎΡΡΡΠ΄Π½ΠΈΡΠ΅ΡΡΠ²Π°. ΠΠ»Ρ Π±ΠΎΠ»Π΅Π΅ ΡΠΎΡΠ½ΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ² ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΡΠ΄Π½ΠΈΡΠ΅ΡΡΠ²Π°, Π°Π²ΡΠΎΡΠ°ΠΌΠΈ Π±ΡΠ» ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π²Π΅ΡΡΠΈΠΈ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎΠΉ Π³ΡΠ°Π²ΠΈΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ Π²Π½Π΅ΡΠ½Π΅ΠΉ ΡΠΎΡΠ³ΠΎΠ²Π»ΠΈ ΠΠ΅Π»Π°ΡΡΡΠΈ ΡΠΎ ΡΡΡΠ°Π½Π°ΠΌΠΈ-ΡΡΠ°ΡΡΠ½ΠΈΡΠ°ΠΌΠΈ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π°Π²ΡΠΎΡΠ°ΠΌΠΈ Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ ΡΠ°ΠΌΡΠ΅ Π·Π½Π°ΡΠΈΠΌΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° ΠΎΠ±ΡΠ΅ΠΌ ΡΠΎΡΠ³ΠΎΠ²Π»ΠΈ ΡΠΎ ΡΡΡΠ°Π½Π°ΠΌΠΈ-ΡΡΠ°ΡΡΠ½ΠΈΡΠ°ΠΌΠΈ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π°Π½Π°Π»ΠΈΠ·Π° ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΡΠ°ΡΡΠ΅ΡΠ½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊ ΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΡΡΠΎΠ²Π½Ρ ΡΠΊΡΠΏΠΎΡΡΠ° ΠΈ ΠΈΠΌΠΏΠΎΡΡΠ° Π°Π²ΡΠΎΡΡ ΡΠ΄Π΅Π»Π°Π»ΠΈ Π²ΡΠ²ΠΎΠ΄ ΠΎΠ± ΡΡΠΎΠ²Π½Π΅ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΠΎΡΠ³ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΡΠΎ ΡΡΡΠ°Π½Π°ΠΌΠΈ Π¨ΠΠ‘, Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΡΠ΅Π³ΠΎ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ ΠΏΡΡΠΈ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΠΎΡΠ³ΠΎΠ²Π»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π°Π½Π°Π»ΠΈΠ·Π° ΡΠΎΠ²Π°ΡΠ½ΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ ΠΏΠΎΡΠΎΠΊΠΎΠ² Π²Π½Π΅ΡΠ½Π΅ΠΉ ΡΠΎΡΠ³ΠΎΠ²Π»ΠΈ Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠΈ ΠΠ΅Π»Π°ΡΡΡΡ Ρ ΡΡΠ°ΡΡΠ½ΠΈΡΠ°ΠΌΠΈ ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ
<em>Malus</em> Wild Species of Kazakhstan and Their Conservation <em>In Situ</em>
Kazakhstan has concentrated unique genetic resources of plant agrobiodiversity of world significance. It has received international recognition for fruit agro-biodiversity and, above all, wild apple, which is highly resistant to many diseases, high frost resistance, and wide ecological plasticity. Kazakhstan is the original genetic center of biological variability of wild apples and, historically, has formed their rich gene pool. Wild apple species in Kazakhstan are genetically kindred to cultivated varieties of the world. Genetic diversity and polymorphism of Malus Sieversii (Ledeb.) from Ile Alatau and Dzhungraian Alatau were studied with ISSR markers. Also, results of in vitro cold storage of wild apple varieties are presented
The organization of the virus-tested planting material production for the grape varieties of the local and foreign selection in Kazakhstan
The intensification of viniculture involves the organization of the virus-tested planting material production, establishment of the basic parent plantings, certification of the virus-tested planting material with the control of genetic stability of the grape plants propagated in tissue culture. The modified nutritional medium was developed for microclonal propagation of vine in vitro with the content of the free amino acids: glycine and glutamine, increasing propagation factor up to 15% and the number of nodes on microplant up to 27%
Looking for Plum pox virus at the agro-ecological interface in Central Asia
UMR BFP - Equipe VirologieLooking for[i] Plum pox virus[/i] at the agro-ecological interface in Central Asia. 16. Rencontres de Virologie VΓ©gΓ©tale (RVV 2017
Looking for Plum pox virus at the agro-ecological interface in Central Asia
Looking for[i] Plum pox virus[/i] at the agro-ecological interface in Central Asia. 16. Rencontres de Virologie VΓ©gΓ©tale (RVV 2017
Lipid peroxidation and antioxidant protection in girls with type 1 diabetes mellitus during reproductive system development
Background and objective: Type 1 diabetes mellitus (T1D) is found worldwide and is regarded as one of the main risks to human health. The objective of this study was to determine the state of lipid peroxidation (LPO) and antioxidant protection in girls with T1D type considering the stages of reproductive system development.
Materials and methods: This study enrolled 56 young girls with T1D and 60 healthy girls (control) matched by age. The study population was divided into 3 age groups: prepubertal, adolescent, and juvenile. The state of LPO and antioxidant system was assessed using the coefficient of oxidative stress that represented the ratio of LPO products to general antioxidative blood activity. Spectrophotometric and fluorometric methods were applied.
Results: The results of our study showed increased conjugated diene (CD) and thiobarbituric acid reactant (TBAR) concentrations as well as a decreased reduced glutathione level in prepubertal girls with T1D. Adolescent girls with T1D had a significantly greater CD level and juvenile girls with T1D had a significantly greater TBAR level and lower Ξ±-tocopherol concentration than girls in the control group. The greatest coefficient of oxidative stress (1.16) was observed in the prepubertal period.
Conclusions: The prepubertal period is characterized by the most severe state of lipid peroxidation processβantioxidant protection
Antioxidant Properties of Fullerene Derivatives Depend on Their Chemical Structure: A Study of Two Fullerene Derivatives on HELFs
Oxidative stress is a major issue in a wide number of pathologies (neurodegenerative, cardiovascular, immune diseases, and cancer). Because of this, the search for new antioxidants is an important issue. One of the potential antioxidants that has been enthusiastically discussed in the past twenty years is fullerene and its derivatives. Although in aqueous solutions fullerene derivatives have shown to be antioxidants, their properties in this regard within the cells are controversially discussed. We have studied two different water-soluble fullerene C60 and C70 derivatives on human embryonic lung fibroblasts at a wide range of concentrations. Both of them cause a decrease in cellular ROS at short times of incubation (1 hour). Their prolonged action, however, is fundamentally different: derivative GI-761 causes secondary oxidative stress whereas derivative VI-419-P3K keeps ROS levels under control values. To gain a better understanding of this effect, we assessed factors that could play a role in the response of cells to fullerene derivatives. Increased ROS production occurred due to NOX4 upregulation by GI-761. Derivative VI-419-P3K activated the transcription of antioxidant master regulator NRF2 and caused its translocation to the nucleus. This data suggests that the antioxidant effect of fullerene derivatives depends on their chemical structure
Amphiphilic Poly(N-vinylpyrrolidone) Nanoparticles Conjugated with DR5-Specific Antitumor Cytokine DR5-B for Targeted Delivery to Cancer Cells
Nanoparticles based on the biocompatible amphiphilic poly(N-vinylpyrrolidone) (Amph-PVP) derivatives are promising for drug delivery. Amph-PVPs self-aggregate in aqueous solutions with the formation of micellar nanoscaled structures. Amph-PVP nanoparticles are able to immobilize therapeutic molecules under mild conditions. As is well known, many efforts have been made to exploit the DR5-dependent apoptosis induction for cancer treatment. The aim of the study was to fabricate Amph-PVP-based nanoparticles covalently conjugated with antitumor DR5-specific TRAIL (Tumor necrosis factor-related apoptosis-inducing ligand) variant DR5-B and to evaluate their in vitro cytotoxicity in 3D tumor spheroids. The Amph-PVP nanoparticles were obtained from a 1:1 mixture of unmodified and maleimide-modified polymeric chains, while DR5-B protein was modified by cysteine residue at the N-end for covalent conjugation with Amph-PVP. The nanoparticles were found to enhance cytotoxicity effects compared to those of free DR5-B in both 2D (monolayer culture) and 3D (tumor spheroids) in vitro models. The cytotoxicity of the nanoparticles was investigated in human cell lines, namely breast adenocarcinoma MCF-7 and colorectal carcinomas HCT116 and HT29. Notably, DR5-B conjugation with Amph-PVP nanoparticles sensitized resistant multicellular tumor spheroids from MCF-7 and HT29 cells. Taking into account the nanoparticles loading ability with a wide range of low-molecular-weight antitumor chemotherapeutics into hydrophobic core and feasibility of conjugation with hydrophilic therapeutic molecules by click chemistry, we suggest further development to obtain a versatile system for targeted drug delivery into tumor cells