Экономический потенциал Республики Беларусь после присоединения к ШОС: преимущества и возможности

In the era of globalization, integration groupings have become an important tool for the development of many countries in the world economy. They contribute to the formation of close economic ties and coordination of foreign trade between the participants, which in turn has a favorable effect on the development of the national economy of the country. Participation in integration associations is of great importance for the development of Belarus’ economy and increasing its role in the international arena. Membership in the SCO opens up new prospects for the country and provides an opportunity to expand cooperation with other countries of the Asian region. Once Belarus becomes a full-fledged member of the association, the country will have new ways to develop its potential in various areas, including the economy, logistics, transport, security, culture, education, healthcare, tourism, industrial and agricultural sector, science, as well as experience in international multilateral cooperation. The article is devoted to the topic of assessing the potential of joining the Shanghai Cooperation Organization integration association of the Republic of Belarus. In order to assess the prospects of economic cooperation more accurately, the authors conducted an econometric analysis using a modified version of the traditional gravity model of Belarus’ foreign trade with the member countries. As a result, the authors have identified the most significant factors influencing the volume of trade with the member countries. By analyzing the ratio of calculated indicators to the actual level of exports and imports, the authors made a conclusion about the level of realization of trade potential with the SCO countries. As a consequence, the authors proposed possible ways to implement trade by analyzing the commodity structure of foreign trade flows of the Republic of Belarus with the members of the integration association.В эпоху глобализации интеграционные группировки стали важным инструментом для развития множества стран в мировом хозяйстве. Они способствуют формированию тесных экономических связей и координации внешней торговли между участниками, что, в свою очередь, благоприятно сказывается на развитии национальной экономики страны. Участие в интеграционных объединениях имеет большое значение для развития экономики Беларуси и увеличения ее роли на международной арене. Вступление в ШОС открывает новые перспективы для страны и дает возможность расширять кооперацию с другими странами Азиатского региона. После становления Беларуси полноправным участником объединения перед страной откроются новые пути развития потенциала в различных сферах, включая экономику, логистику, транспорт, безопасность, культуру, образование, здравоохранение, туризм, промышленный и сельскохозяйственный сектор, науку, а также опыт международного многостороннего сотрудничества. Исследование посвящено оценке потенциала вступления Республики Беларусь в интеграционное объединение Шанхайской организации сотрудничества. Для более точной оценки перспектив экономического сотрудничества, авторами был проведен эконометрический анализ с использованием модифицированной версии традиционной гравитационной модели внешней торговли Беларуси со странами-участницами. В результате авторами были выявлены самые значимые факторы влияния на объем торговли со странами-участницами. В результате анализа отношения расчетных показателей к фактическому уровню экспорта и импорта авторы сделали вывод об уровне реализации торгового потенциала со странами ШОС, вследствие чего предложены возможные пути реализации торговли с помощью анализа товарной структуры потоков внешней торговли Республики Беларусь с участницами интеграционного объединения

<em>Malus</em> Wild Species of Kazakhstan and Their Conservation <em>In Situ</em>

Kazakhstan has concentrated unique genetic resources of plant agrobiodiversity of world significance. It has received international recognition for fruit agro-biodiversity and, above all, wild apple, which is highly resistant to many diseases, high frost resistance, and wide ecological plasticity. Kazakhstan is the original genetic center of biological variability of wild apples and, historically, has formed their rich gene pool. Wild apple species in Kazakhstan are genetically kindred to cultivated varieties of the world. Genetic diversity and polymorphism of Malus Sieversii (Ledeb.) from Ile Alatau and Dzhungraian Alatau were studied with ISSR markers. Also, results of in vitro cold storage of wild apple varieties are presented

The organization of the virus-tested planting material production for the grape varieties of the local and foreign selection in Kazakhstan

The intensification of viniculture involves the organization of the virus-tested planting material production, establishment of the basic parent plantings, certification of the virus-tested planting material with the control of genetic stability of the grape plants propagated in tissue culture. The modified nutritional medium was developed for microclonal propagation of vine in vitro with the content of the free amino acids: glycine and glutamine, increasing propagation factor up to 15% and the number of nodes on microplant up to 27%

Looking for Plum pox virus at the agro-ecological interface in Central Asia

UMR BFP - Equipe VirologieLooking for[i] Plum pox virus[/i] at the agro-ecological interface in Central Asia. 16. Rencontres de Virologie Végétale (RVV 2017

Looking for Plum pox virus at the agro-ecological interface in Central Asia

Looking for[i] Plum pox virus[/i] at the agro-ecological interface in Central Asia. 16. Rencontres de Virologie Végétale (RVV 2017

Lipid peroxidation and antioxidant protection in girls with type 1 diabetes mellitus during reproductive system development

Background and objective: Type 1 diabetes mellitus (T1D) is found worldwide and is regarded as one of the main risks to human health. The objective of this study was to determine the state of lipid peroxidation (LPO) and antioxidant protection in girls with T1D type considering the stages of reproductive system development. Materials and methods: This study enrolled 56 young girls with T1D and 60 healthy girls (control) matched by age. The study population was divided into 3 age groups: prepubertal, adolescent, and juvenile. The state of LPO and antioxidant system was assessed using the coefficient of oxidative stress that represented the ratio of LPO products to general antioxidative blood activity. Spectrophotometric and fluorometric methods were applied. Results: The results of our study showed increased conjugated diene (CD) and thiobarbituric acid reactant (TBAR) concentrations as well as a decreased reduced glutathione level in prepubertal girls with T1D. Adolescent girls with T1D had a significantly greater CD level and juvenile girls with T1D had a significantly greater TBAR level and lower α-tocopherol concentration than girls in the control group. The greatest coefficient of oxidative stress (1.16) was observed in the prepubertal period. Conclusions: The prepubertal period is characterized by the most severe state of lipid peroxidation process–antioxidant protection

Antioxidant Properties of Fullerene Derivatives Depend on Their Chemical Structure: A Study of Two Fullerene Derivatives on HELFs

Oxidative stress is a major issue in a wide number of pathologies (neurodegenerative, cardiovascular, immune diseases, and cancer). Because of this, the search for new antioxidants is an important issue. One of the potential antioxidants that has been enthusiastically discussed in the past twenty years is fullerene and its derivatives. Although in aqueous solutions fullerene derivatives have shown to be antioxidants, their properties in this regard within the cells are controversially discussed. We have studied two different water-soluble fullerene C60 and C70 derivatives on human embryonic lung fibroblasts at a wide range of concentrations. Both of them cause a decrease in cellular ROS at short times of incubation (1 hour). Their prolonged action, however, is fundamentally different: derivative GI-761 causes secondary oxidative stress whereas derivative VI-419-P3K keeps ROS levels under control values. To gain a better understanding of this effect, we assessed factors that could play a role in the response of cells to fullerene derivatives. Increased ROS production occurred due to NOX4 upregulation by GI-761. Derivative VI-419-P3K activated the transcription of antioxidant master regulator NRF2 and caused its translocation to the nucleus. This data suggests that the antioxidant effect of fullerene derivatives depends on their chemical structure

Amphiphilic Poly(N-vinylpyrrolidone) Nanoparticles Conjugated with DR5-Specific Antitumor Cytokine DR5-B for Targeted Delivery to Cancer Cells

Nanoparticles based on the biocompatible amphiphilic poly(N-vinylpyrrolidone) (Amph-PVP) derivatives are promising for drug delivery. Amph-PVPs self-aggregate in aqueous solutions with the formation of micellar nanoscaled structures. Amph-PVP nanoparticles are able to immobilize therapeutic molecules under mild conditions. As is well known, many efforts have been made to exploit the DR5-dependent apoptosis induction for cancer treatment. The aim of the study was to fabricate Amph-PVP-based nanoparticles covalently conjugated with antitumor DR5-specific TRAIL (Tumor necrosis factor-related apoptosis-inducing ligand) variant DR5-B and to evaluate their in vitro cytotoxicity in 3D tumor spheroids. The Amph-PVP nanoparticles were obtained from a 1:1 mixture of unmodified and maleimide-modified polymeric chains, while DR5-B protein was modified by cysteine residue at the N-end for covalent conjugation with Amph-PVP. The nanoparticles were found to enhance cytotoxicity effects compared to those of free DR5-B in both 2D (monolayer culture) and 3D (tumor spheroids) in vitro models. The cytotoxicity of the nanoparticles was investigated in human cell lines, namely breast adenocarcinoma MCF-7 and colorectal carcinomas HCT116 and HT29. Notably, DR5-B conjugation with Amph-PVP nanoparticles sensitized resistant multicellular tumor spheroids from MCF-7 and HT29 cells. Taking into account the nanoparticles loading ability with a wide range of low-molecular-weight antitumor chemotherapeutics into hydrophobic core and feasibility of conjugation with hydrophilic therapeutic molecules by click chemistry, we suggest further development to obtain a versatile system for targeted drug delivery into tumor cells