Cox hazard univariate and multivariate survival analyses of proliferation assessment methods for recurrence-free survival.

<p>Cox hazard univariate and multivariate survival analyses of proliferation assessment methods for recurrence-free survival.</p

Comparisons of labelling indices.

<p>Comparisons of labelling indices.</p

Differences in proliferation indices (PIs) between WHO grades and recurrent/non-recurrent meningioma.

<p>Differences in proliferation indices (PIs) between WHO grades and recurrent/non-recurrent meningioma.</p

Grouped scatter plot of labeling indices in recurrent vs. non-recurrent meningiomas.

<p>Survivin LIs were significantly higher in recurrent meningiomas compared to non-recurrent meningiomas, while no difference was found in MIB-1 LI.</p

Immunostaining of anti-survivin.

<p>Examples of survivin immunostaining in a non-recurrent meningioma (A) and a recurrent meningioma (B) (magnitude 400x). The expression of survivin was significantly higher in recurrent meningiomas compared with non-recurrent meningiomas. The bar on the figures represent 100 μm.</p

Kaplan-Meier plot of survivin labeling index (LI) < 1% vs. > 1%.

<p>Patients with survivin LI > 1% had significant shorter recurrence-free survival compared to patients with survivin LI < 1%.</p

Clinical data according to 2016 WHO histopathological grade.

<p>Clinical data according to 2016 WHO histopathological grade.</p

Kaplan-Meier curves and recurrence-free survival (RFS).

<p>Meningioma patients were stratified by optimal cutoff values revealed by receiver operator characteristics (ROC). Histopathological grade (A), MIB-1 PI (B), topoisomerase IIα (C), and mitosin (D). Topoisomerase IIα and mitosin expression were demonstrated to be predictors of RFS, but no association was found with histopathological grade or MIB-1.</p

Receiver operator characteristics (ROC) analyses of cutoff values.

<p>Receiver operator characteristics (ROC) analyses of cutoff values.</p

Cox hazard univariate and multivariate survival analyses of proliferation assessment methods.

<p>Cox hazard univariate and multivariate survival analyses of proliferation assessment methods.</p