Prevalence of Rheumatoid Arthritis in the Southern Part of Denmark

The aim of the present study was to estimate the prevalence of rheumatoid arthritis in the southern part of Denmark. Using a screening questionnaire, telephone interview, register data, and a clinical examination cases were ascertained from a random sample of 4995 individuals over the age of 15. As case definition we used the original and modified 1987 American College of Rheumatology classification criteria. The overall point prevalence was 0.26% (95% confidence interval: 0.13-0.39) in the total sample and 0.35% (95% confidence interval: 0.17-0.52) among the responders; the cumulative prevalence was 0.75% (95% confidence interval: 0.52-0.97) in the total sample and 0.92% (95% confidence interval: 0.62-1.21) among the responders

The liquidity management of the ECB

Consultant presentation describing the ECB\u27s frontloading polic

Skovens frivillige ledere

Hvordan får frivillige ledere samarbejdet med de frivillige hjælpere til at lykkes? Sådanne ledelseskompetencer i en ikke-profession vil forventeligt i nogen grad også kunne overføres til en given leders profession. Med udgangspunkt i spilteori og data fra Smukfest gives to hovedforklaringer. Først er de som hard-ridere gode til at skabe sociale relationer og belønne hard-rider medhjælpere via retfærdig social anerkendelse for deres indsats. Her skabes en ekstra social gevinst ved tillidsbaseret samarbejde. For det andet er nogle hard-rider ledere klar til, som tough-ridere, at opdrage en easy-rider hjælper via samtale og krav om arbejde eller ej. Samlet gives her et vigtigt signal i forhold til, hvad forventningen er, så easy-ridere ikke belønnes og dermed ikke fortrænger hard-ridere i fremtiden

A third-generation dispersion and third-generation hydrogen bonding corrected PM6 method:PM6-D3H+

We present new dispersion and hydrogen bond corrections to the PM6 method, PM6-D3H+, and its implementation in the GAMESS program. The method combines the DFT-D3 dispersion correction by Grimme et al. with a modified version of the H+ hydrogen bond correction by Korth. Overall, the interaction energy of PM6-D3H+ is very similar to PM6-DH2 and PM6-DH+, with RMSD and MAD values within 0.02 kcal/mol of one another. The main difference is that the geometry optimizations of 88 complexes result in 82, 6, 0, and 0 geometries with 0, 1, 2, and 3 or more imaginary frequencies using PM6-D3H+ implemented in GAMESS, while the corresponding numbers for PM6-DH+ implemented in MOPAC are 54, 17, 15, and 2. The PM6-D3H+ method as implemented in GAMESS offers an attractive alternative to PM6-DH+ in MOPAC in cases where the LBFGS optimizer must be used and a vibrational analysis is needed, e.g., when computing vibrational free energies. While the GAMESS implementation is up to 10 times slower for geometry optimizations of proteins in bulk solvent, compared to MOPAC, it is sufficiently fast to make geometry optimizations of small proteins practically feasible

Reuse for Research: Curating Astrophysical Datasets for Future Researchers

“Our data are going to be valuable for science for the next 50 years, so please make sure you preserve them and keep them accessible for active research for at least that period.” These were approximately the words used by the principal investigator of the Kepler Asteroseismic Science Consortium (KASC) when he presented our task to us. The data in question consists of data products produced by KASC researchers and working groups as part of their research, as well as underlying data imported from the NASA archives. The overall requirements for 50 years of preservation while, at the same time, enabling reuse of the data for active research presented a number of specific challenges, closely intertwining data handling and data infrastructure with scientific issues. This paper reports our work to deliver the best possible solution, performed in close cooperation between the research team and library personnel