IHC analysis of TMA of non-GIST STS representing different scores of expression of dedifferentiation related markers in tumor cells.

<p>A, Leiomyosarcoma, histological grade I, E-cadherin, negative staining, score 0; B, Dedifferentiated liposarcoma, histological grade II, TGF-β1, weak staining, score 1; C, Pleomorphic liposarcoma, histological grade III, Fascin, moderate staining; score 2; D, Alveolar rhabdomyosarcoma, histological grade III, Vimentin, strong staining, score 3. All calibration bars correspond to 100 µm. Abbreviations; IHC, immunohistochemistry; TMA, tissue microarray; non-GIST STS, non gastro-intestinal stromal tumor soft-tissue sarcoma; TGF-β1, transforming growth factor beta 1.</p

Prognostic clinicopathological variables as predictors for disease-specific survival in 249 non-GIST STSs (univariate analyses, log-rank test).

<p>Abbreviations: NR, not reached; MF/MFT, malignant fibroblastic/myofibroblastic tumors; MPNST, malignant peripheral nerve sheath tumor; NOS, not otherwise specified; non-GIST STS, non-gastro intestinal stromal tumor soft-tissue sarcoma.</p

Disease-specific survival curves for dedifferentiation-associated markers.

<p>A, TGF-β1; B, Fascin; C, NF-κB p105; D, PKC-ζ. Abbreviations: TGF-β1, transforming growth factor beta 1; NF-κB, nuclear factor-κB; PKC-ζ, protein kinase C zeta.</p

Results of the Cox regression analysis summarizing significant independent prognostic factors in the overall material.

<p>Abbreviations: TGF-β1, transforming growth factor beta 1.</p><p>*Overall significance as a prognostic factor.</p

Results of subgroup analysis of patients with CD20+ lymphocytes in tumor and wide resection margins, n = 108.

<p>* Median survival is not computed because all cases are censored.</p><p>Abbreviations: NR, not reached.</p

IHC microscopic pictures of TMA of soft tissue sarcoma representing different scores for CD4+ and CD20+ lymphocytes.

<p>(A) CD4 low score; (B) CD4 high score; (C) CD20 low score; (D) CD20 high score. Original magnification X 400.</p

Correlation of marker expression in patients with soft tissue sarcomas (Pearson correlation), N = 193.

*<p>Correlation is significant at the 0.05 level (2 tailed).</p>**<p>Correlation is significant at the 0.01 level (2 tailed).</p

Disease-specific survival curves for patients with wide resection margins compared to patients with non-wide resection margins.

<p>Disease-specific survival curves for patients with wide resection margins compared to patients with non-wide resection margins.</p

Prognostic clinicopathologic variables as predictors for disease-specific survival soft tissue sarcomas (univariate analysis, log rank test), N = 249.

<p>Abbreviations: MF/MFT, malignant fibroblastic/myofibroblastic tumors; MPNST, malignant peripheral nerve sheath tumor; STS, soft tissue sarcomas; NR, not reached; NOS, non specified.</p

Disease-specific survival curves for CD3+, CD4+, CD8+, CD20+ and CD45+ lymphocytes in STS with wide resection margins.

<p>Disease-specific survival curves for CD3+, CD4+, CD8+, CD20+ and CD45+ lymphocytes in STS with wide resection margins.</p