State Resolved Thermochemical Modeling of Nitrogen Using DSMC

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97088/1/AIAA2012-2991.pd

Astrodynamical Space Test of Relativity using Optical Devices I (ASTROD I) - A class-M fundamental physics mission proposal for Cosmic Vision 2015-2025: 2010 Update

This paper on ASTROD I is based on our 2010 proposal submitted for the ESA call for class-M mission proposals, and is a sequel and an update to our previous paper [Experimental Astronomy 23 (2009) 491-527; designated as Paper I] which was based on our last proposal submitted for the 2007 ESA call. In this paper, we present our orbit selection with one Venus swing-by together with orbit simulation. In Paper I, our orbit choice is with two Venus swing-bys. The present choice takes shorter time (about 250 days) to reach the opposite side of the Sun. We also present a preliminary design of the optical bench, and elaborate on the solar physics goals with the radiation monitor payload. We discuss telescope size, trade-offs of drag-free sensitivities, thermal issues and present an outlook. ASTROD I is a planned interplanetary space mission with multiple goals. The primary aims are: to test General Relativity with an improvement in sensitivity of over 3 orders of magnitude, improving our understanding of gravity and aiding the development of a new quantum gravity theory; to measure key solar system parameters with increased accuracy, advancing solar physics and our knowledge of the solar system; and to measure the time rate of change of the gravitational constant with an order of magnitude improvement and the anomalous Pioneer acceleration, thereby probing dark matter and dark energy gravitationally. It is envisaged as the first in a series of ASTROD missions. ASTROD I will consist of one spacecraft carrying a telescope, four lasers, two event timers and a clock. Two-way, two-wavelength laser pulse ranging will be used between the spacecraft in a solar orbit and deep space laser stations on Earth, to achieve the ASTROD I goals.Comment: 15 pages, 11 figures, 1 table, based on our 2010 proposal submitted for the ESA call for class-M mission proposals, a sequel and an update to previous paper [Experimental Astronomy 23 (2009) 491-527] which was based on our last proposal submitted for the 2007 ESA call, submitted to Experimental Astronom

Human resources for health policies: a critical component in health policies

In the last few years, increasing attention has been paid to the development of health policies. But side by side with the presumed benefits of policy, many analysts share the opinion that a major drawback of health policies is their failure to make room for issues of human resources. Current approaches in human resources suggest a number of weaknesses: a reactive, ad hoc attitude towards problems of human resources; dispersal of accountability within human resources management (HRM); a limited notion of personnel administration that fails to encompass all aspects of HRM; and finally the short-term perspective of HRM. There are three broad arguments for modernizing the ways in which human resources for health are managed: • the central role of the workforce in the health sector; • the various challenges thrown up by health system reforms; • the need to anticipate the effect on the health workforce (and consequently on service provision) arising from various macroscopic social trends impinging on health systems. The absence of appropriate human resources policies is responsible, in many countries, for a chronic imbalance with multifaceted effects on the health workforce: quantitative mismatch, qualitative disparity, unequal distribution and a lack of coordination between HRM actions and health policy needs. Four proposals have been put forward to modernize how the policy process is conducted in the development of human resources for health (HRH): • to move beyond the traditional approach of personnel administration to a more global concept of HRM; • to give more weight to the integrated, interdependent and systemic nature of the different components of HRM when preparing and implementing policy; • to foster a more proactive attitude among human resources (HR) policy-makers and managers; • to promote the full commitment of all professionals and sectors in all phases of the process. The development of explicit human resources policies is a crucial link in health policies and is needed both to address the imbalances of the health workforce and to foster implementation of the health services reforms

Structure-Based Stabilization of HIV-1 gp120 Enhances Humoral Immune Responses to the Induced Co-Receptor Binding Site

The human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein, gp120, possesses conserved binding sites for interaction with the primary virus receptor, CD4, and also for the co-receptor, generally CCR5. Although gp120 is a major target for virus-specific neutralizing antibodies, the gp120 variable elements and its malleable nature contribute to evasion of effective host-neutralizing antibodies. To understand the conformational character and immunogenicity of the gp120 receptor binding sites as potential vaccine targets, we introduced structure-based modifications to stabilize gp120 core proteins (deleted of the gp120 major variable regions) into the conformation recognized by both receptors. Thermodynamic analysis of the re-engineered core with selected ligands revealed significant stabilization of the receptor-binding regions. Stabilization of the co-receptor-binding region was associated with a marked increase in on-rate of ligand binding to this site as determined by surface plasmon resonance. Rabbit immunization studies showed that the conformational stabilization of core proteins, along with increased ligand affinity, was associated with strikingly enhanced humoral immune responses against the co-receptor-binding site. These results demonstrate that structure-based approaches can be exploited to stabilize a conformational site in a large functional protein to enhance immunogenic responses specific for that region

Buku Teks Analisis Anorganik Kualitatif Makro Dan Semimikro

xv 656 ha

Textbook of Macro and Semimicro qualitative Inorganic Analysis

xiii;ill.;605hal.;22c

Buku teks analisis anorganik kualitatif makro dan semimikro bagian 1 : Vogel / edisi kelima

xv, ix. 8 p. ; 24 cm