2 research outputs found
Supplementary Material for: International online survey on the management of patent ductus arteriosus
Introduction
There is uncertainty and lack of consensus regarding optimal management of patent ductus arteriosus (PDA). We aimed to determine current clinical practice in PDA management across a range of different regions internationally.
Materials and Methods
We surveyed PDA management practices in neonatal intensive care units using a pre-piloted web-based survey, which was distributed to perinatal societies in 31 countries. The survey was available online from March 2018 to March 2019.
Results
There were 812 responses. The majority of clinicians (54%) did not have institutional protocols for PDA treatment and 42% reported variable management within their own unit. Among infants <28 weeks (or <1000g), most clinicians (60%) treat symptomatically. Respondents in Australasia were more likely to treat PDA pre-symptomatically (44% vs 18% all countries [OR 4.1; 95% CI 2.6-6.5; p<0.001]) and respondents from North America were more likely to treat symptomatic PDA (67% vs 60% all countries [OR 2.0; 95% CI 1.5-2.6; p<0.001]). In infants ≥28 weeks (or ≥1000g), most clinicians (54%) treat symptomatically. Respondents in North America were more likely to treat PDAs in this group of infants conservatively (47% vs 38% all countries [OR 2.3; 95% CI 1.7-3.2]; p<0.001) and respondents from Asia were more likely to treat the PDA pre-symptomatically (21% vs 7% all countries [OR 5.5; 95% CI 3.2-9.8; p<0.001]).
Discussion/Conclusion
There were marked international differences in clinical practice, highlighting ongoing uncertainty and a lack of consensus regarding PDA management. An international conglomeration to coordinate research that prioritises and addresses these areas of contention is indicated
Supplementary Material for: The Prevalence of and Factors Related to Vascular Hyperintensity on T1-Weighted Imaging in Acute Ischemic Stroke
<p><b><i>Background:</i></b> Thrombus visualization in patients with
acute ischemic stroke has been detected and reported using various
imaging modalities. T1-weighted imaging (T1-WI) can depict thrombi as
hyperintense signals within vessels. Moreover, in addition to thrombi,
T1-WI hyperintensities in arteries may suggest arterial dissection.
However, the frequency of and factors related to the T1-hyperintense
vessel sign (T1-HVS) are not fully known. The aim of this study was to
clarify the prevalence of and related factors for the T1-HVS in patients
with acute ischemic stroke. <b><i>Methods:</i></b> From September 2014
through December 2015, consecutive acute ischemic stroke patients who
were admitted to our stroke unit within 7 days from symptom onset were
retrospectively recruited from the prospective registry. A T1-HVS was
defined as the presence of a hyperintense signal, with intensity higher
than surrounding brain, within the vessel lumen. Moreover, T1-HVSs were
separated into filled T1-HVSs (hyperintensity fills whole vessel lumen)
and non-filled T1-HVSs. The frequency of the T1-HVS and the timing of
emersion and the relationship between the presence of the T1-HVS and
arterial occlusion were assessed. <b><i>Results:</i></b> A total of 399
patients (139 women; median age 73 years; National Institutes of Health
Stroke Scale score 3) were enrolled in the present study. Of these, 327
(82%) patients had T1-WI on admission. Two hundred and sixty-seven (67%)
subjects had at least one follow-up T1-WI (median 6 days after
admission), and 134 (34%) cases had ≥2 follow-up T1-WI examinations. The
T1-HVS was observed in 18 patients during admission; therefore, the
frequency of the T1-HVS in acute ischemic stroke patients was 4.5% (95%
CI 2.5-6.5%). All but one (94%) of the T1-HVSs were first observed on
follow-up imaging, and the median number of days from onset to T1-HVS
appearance was 9. For patients having initial major artery occlusion and
follow-up MRI (<i>n</i> = 95), sensitivity and specificity of the
T1-HVS for persistent arterial occlusion on follow-up MR angiography
were 22 and 100%, respectively. T1-HVS persisted for a few months and
then normalized. Although there were no significant differences between
filled and non-filled T1-HVS, more patients with non-filled T1-HVS had
arterial dissection (43%) than those with filled T1-HVS (9%, <i>p</i> = 0.245). <b><i>Conclusion:</i></b>
The T1-HVS was observed in 4.5% of acute ischemic stroke patients.
T1-HVSs appeared in the subacute phase in arteries with persistent
occlusion and remained for a few months.</p