4 research outputs found
The distribution of HBV integration sites, mutational status of selected tumor suppressor genes and numbers of chromosomal aberrations identified in the 25 patients whose samples were assayed using aCGH assay.
<p>
<b>W/O = without mutation; Low aberration number = less than 100 chromosomal aberrations; High aberration number = more than 100 chromosomal aberrations.</b></p
Precise locations of HBV integration events mapped to the FN1 gene.
<p>The chromosome locations were mapped using the UCSC database. The orientation of the cellular gene was compared with that of the integrated HBV genome: same = same direction while opposite = opposite direction.</p
The distribution of break-points in the HBV genome in integrated viral sequences detected using different viral primers.
<p>A and B, HBV genome break-points were obtained using HBV specific primers (S1 and pUTP) lying downstream of the HBx region. C and D, HBV genome break-points were obtained using a primer (HBV1920R) lying downstream of the HBV core region. Solid and Hollow dots represent virus-cell junction sites from tumor derived and non-tumor derived samples respectively. Five of the break-points identified fell outside of the region of the viral genome shown in detail in this figure (at nt 415; nt 2784; nt 1292; nt 546; and nt 3075).</p
Examples of rearrangements of the HBV genome found in integrated viral genomes.
<p>Del = deletion, Ins = insertion.</p