Serial CT Findings of Paragonimus Infested Dogs and the Micro-CT Findings of the Worm Cysts

OBJECTIVE: To investigate the serial CT findings of Paragonimus westermani infected dogs and the microscopic structures of the worm cysts using Micro-CT. MATERIALS AND METHODS: This study was approved by the committee on animal research at our institution. Fifteen dogs infected with P. westermani underwent serial contrast-enhanced CT scans at pre-infection, after 10 days of infection, and monthly thereafter until six months for determining the radiologic-pathologic correlation. Three dogs (one dog each time) were sacrificed at 1, 3 and 6 months, respectively. After fixation of the lungs, both multi-detector CT and Micro-CT were performed for examining the worm cysts. RESULTS: The initial findings were pleural effusion and/or subpleural ground-glass opacities or linear opacities at day 10. At day 30, subpleural and peribronchial nodules appeared with hydropneumothorax and abdominal or chest wall air bubbles. Cavitary change and bronchial dilatation began to be seen on CT scan at day 30 and this was mostly seen together with mediastinal lymphadenopathy at day 60. Thereafter, subpleural ground-glass opacities and nodules with or without cavitary changes were persistently observed until day 180. After cavitary change of the nodules, the migratory features of the subpleural or peribronchial nodules were seen on all the serial CT scans. Micro-CT showed that the cyst wall contained dilated interconnected tubular structures, which had communications with the cavity and the adjacent distal bronchus. CONCLUSION: The CT findings of paragonimiasis depend on the migratory stage of the worms. The worm cyst can have numerous interconnected tubular channels within its own wall and these channels have connections with the cavity and the adjacent distal bronchus

Studies of Thyroxine Iodine Serum as a Measurement of Thyroid Function in 87 Patients

Serum thyroxine iodine determinations after the Murphy and Pattee method were studied in 87 patients. The procedure has been described. The resulting values show excellent discrimination between the thyroid conditions. The method appears to be one of the reliable indices of thyroid conditions

A Simplified Procedure for the Preparation of 131I-Labelled Sulfobromophthalein. Its Applications to Liver Scanning

SummaryA method of preparing 131I-labelled sulfobromophthalein is described. The method is simple and inexpensive. The labelled compound is of particular value where 99mTc-labelled preparations for liver scanning are too expensive or not readily available. It has been used as a liver scanning agent with satisfactory-results, revealing both morphological as well as functional abnormalities in various liver conditions in the same manner as 131I-labelled Rose Bengal.Its use in liver scanning has been extended to the visualization of the liver abscess cavity after intracavitary injection. The method has been used to observe the changes in size and configuration of the abscess cavity during its course of healing under medical treatment. Another extension of the work is the intraductal administration of the labelled compound viaa T-tube to demonstrate the dilatation of the biliary tract in cases of advanced opisthorchiasis.The application of the labelled compound to liver scanning is illustrated.</jats:p