Three-way fungal interactions affect the potential biological control of Himalayan balsam, Impatiens glandulifera

Himalayan balsam (Impatiens glandulifera) is one of the most invasive weeds across Europe. The rust fungus, Puccinia komarovii var. glanduliferae has been introduced as a biological control agent, but success has been patchy. Here, we investigated whether mycorrhizal and endophytic fungi can affect rust efficacy and plant growth. Over three experiments we found that AM fungi and the rust alone or together consistently reduced plant growth, but this depended on the identity of species in the AM inoculum. Meanwhile, AM fungi increased infection frequency of the endophyte Colletotrichum acutatum. Rust inoculation had no detrimental effects on mycorrhizal colonisation or C. acutatum infection, but the latter two fungi reduced rust sporulation. However, plant size was reduced when all three fungal types were present, suggesting that a combined fungal inoculum offers a promising approach for the control of this weed

Regulation of ecto‐apyrase CD39 (ENTPD1) expression by phosphodiesterase III (PDE3)

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154432/1/fsb2027011011.pd

Implications of land-grabbing on the ecological balance of Brazil

In the global free-market, natural resource scarcity and opportunities for preserving the local environment are fostering international purchasing of large extensions of land, mainly for agricultural use. These land transactions often involve land cover change (i.e., through deforestation) or a shift from extensive or traditional to intensive agricultural practices. In Brazil, the land appropriation by foreign investors (i.e., the so-called "land-grabbing") is affecting natural capital availability for local communities to a different extent in the very different territorial entities. At the same time, Brazilian investors are purchasing land in other countries. Ecological footprint accounting is one appropriate lens that can be employed to visualize the aggregated effect of natural capital appropriation and use. The aim of this paper is to provide a first estimate on the effect of land-grabbing on the ecological balance of Brazil through calculating the biocapacity embodied in purchased lands in the different states of Brazil. The results show that Brazil is losing between 9 to 9.3 million global hectares (on a gross basis, or a net total of 7.7 to 8.6 million of global hectares) of its biocapacity due to land-grabbing, when considering respectively a "cropland to cropland" (i.e., no land-cover change) and a "total deforestation" scenario. This represents a minimum estimate, highlighting the need for further land-grabbing data collection at the subnational scale. This analysis can be replicated for other countries of the world, adjusting their ecological balance by considering the biocapacity embodied in international transactions of land

S100/RAGE-Mediated Inflammation and Modified Cholesterol Lipoproteins as Mediators of Osteoblastic Differentiation of Vascular Smooth Muscle Cells

Arterial calcification is a feature of atherosclerosis and shares many risk factors including diabetes, dyslipidemia, chronic kidney disease, hypertension, and age. Although there is overlap in risk factors, anti-atherosclerotic therapies, including statins, fail to reduce arterial, and aortic valve calcifications. This suggests that low density lipoprotein (LDL) may not be the main driver for aortic valve disease and arterial calcification. This review focuses on modified LDLs and their role in mediating foam cell formation in smooth muscle cells (SMCs), with special emphasis on enzyme modified non-oxidized LDL (ELDL). In vivo, ELDL represents one of the many forms of modified LDLs present in the atherosclerotic vessel. Phenotypic changes of macrophages and SMCs brought about by the uptake of modified LDLs overlap significantly in an atherosclerotic milieu, making it practically impossible to differentiate between the effects from oxidized LDL, ELDL, and other LDL modification. By studying in vitro-generated modifications of LDL, we were able to demonstrate marked differences in the transcriptome of human coronary artery SMCs (HCASMCs) upon uptake of ELDL, OxLDL, and native LDL, indicating that specific modifications of LDL in atherosclerotic plaques may determine the biology and functional consequences in vasculature. Enzyme-modified non-oxidized LDL (ELDL) induces calcification of SMCs and this is associated with reduced mRNA levels for genes protective for calcification (ENPP1, MGP) and upregulation of osteoblastic genes. A second focus of this review is on the synergy between hyperlipidemia and accelerated calcification In vivo in a mouse models with transgenic expression of human S100A12. We summarize mechanisms of S100A12/RAGE mediated vascular inflammation promoting vascular and valve calcification in vivo

Doppler ultrasound in the measurement of pulse wave velocity: agreement with the Complior method

Aortic stiffness is an independent predictor factor for cardiovascular risk. Different methods for determining pulse wave velocity (PWV) are used, among which the most common are mechanical methods such as SphygmoCor or Complior, which require specific devices and are limited by technical difficulty in obtaining measurements. Doppler guided by 2D ultrasound is a good alternative to these methods. We studied 40 patients (29 male, aged 21 to 82 years) comparing the Complior method with Doppler. Agreement of both devices was high (R = 0.91, 0.84-0.95, 95% CI). The reproducibility analysis revealed no intra-nor interobserver differences. Based on these results, we conclude that Doppler ultrasound is a reliable and reproducible alternative to other established methods for the measurement of aortic PWV