PENINGKATAN KELARUTAN PENTAGAMAVUNON-0 DENGAN PENAMBAHAN TWEEN 80

Dissolution of drug substance represent one of important conditions in pharmacy area especially in formulation of a drug form. If we like to reach the good imbibition, drug have to stay in the dissolve form, therefore dissolution speed represent the determinant of imbibition speed for the drugs of which difficult to dissolve. Pentagamavunon-0 represent the analogous of kurkumin owning dissolution very small in water. therefore needed an approach in the effort this improvement pentagamavunon-0 with the technique of addition by substance of nonionic surfactan tween 80. To know the ability tween 80 in improving dissolution pentagamavunon-0 done by test of dissolution pentagamavunon-0 with the filtration method in condensation tween 80 rate 3,82 x 10-3M; 7,63 x 10- 3M; 1,53 x 10-2M; 2,29 x 10-2M; 3,05 x 10-2M at temperature 37, 45, 60 C [0,5 C]. Statistic analysis which we used is Kruskal-Wallis H method continued with the Median test. Result of research show the existence of difference meaning of the result test dissolution pentagamavunon-0 at various rate tween 80 (Sig =0,27) and different temperature (Sig.= 0,05) with the highest dissolution pentagamavunon-0 at the addition tween 80 rate 3,82 x 10-3M. React between pentagamavunon-0 and tween 80 happened in exothermic (?H= -13,42554 kal / mole) and spontaniously (?F = - 4857,21; - 4378,66 ; and - 4138,72 kal / mole). Interaction that happened especially entangle the interaction of pattern physical induce pentagamavunon-0 by tween 80 and the solubilisation process happened in the later area palisade continued in the center misel

THE RATIONALITY OF ANTIBIOTICS THERAPY TOWARD CHILDREN WITH TYPHOID FEVER AT M.M. DUNDA HOSPITAL

Objectives: Typhoid fever is an acute systemic infectious disease in the small intestine caused by Salmonella enterica serotype typhi (Salmonella typhi) having the symptoms of fever a week or more with impairment of the gastrointestinal tract with or without impaired consciousness. The purpose of this study was to determine the rationality of antibiotic therapy in pediatric patients at M.M Dunda Limboto Hospital.Methods: This research belongs to non-experimental descriptive with retrospective data retrieval. The data used were obtained from 83 medical records of childhood typhoid patients during 6 months (June–November 2016) at the regional general hospital of M.M Dunda Limboto. These data were analyzed using the Gyssens criteria.Results: The results showed that the most antibiotics used by physicians were ceftriaxone 39% of the use of antibiotic quality which was category IIB 9%, category IIA 13%, and category 0 (rational) 52%.Conclusion: The rationality of antibiotic therapy in children with typhoid fever at M.M Dunda Limboto Hospital was 52% of the most antibiotics used, i.e. ceftriaxone (39%).Â

Evaluasi Mutu Pelayanan Kefarmasian Berdasarkan Standar Pelayanan Minimal (Spm) Di Instalasi Farmasi

Quality refers to compliance with predetermined standards or by requirements. The minimum service standard (MSS) in the health sector at the hospital is crucial because it is a measure of the hospital's performance of health services. This study was intended to describe the service quality in the pharmacy installation of Toto Hospital in Kabila based on four indicators of minimum pharmacy service standards, viz. drug waiting time for treatment completion, the absence of drug administration errors, customer satisfaction, and prescription writing according to the formulary. This descriptive cross-sectional research involved 154 outpatients and inpatients for the category of prescription writing according to the formulary and 154 outpatients for other categories as respondents as samples. Besides, the instruments were a customer satisfaction questionnaire and observation sheet. The results showed that the indicators of waiting time were nine minutes seven seconds and 18 minutes six seconds for concocted drug treatment; there was no error in administering drugs by 100%; customer satisfaction was 86.9%, and; prescription writing according to the formulary was 92.7%. . It was concluded that the Pharmacy Installation of Toto Hospital had not met the specified Minimum Service Standards (MSS)

Kepatuhan Penggunaan Obat Asma Terhadap Kualitas Hidup Pasien Asma Rawat Jalan Rumah Sakit X Gorontalo

Asthma, a chronic disease, is characterized by the inflammation in the respiratory tract, followed by coughing, wheezing, and difficulty breathing. This cross-sectional research was intended to explore the effect of medical compliance on the quality of life of outpatients with asthma. It employed a non-experimental analysis. All 30 respondents were outpatients visiting Gorontalo x hospital they were selected purposively. The compliance level was examined using a relevant questionnaire, while the quality of life was examined using Mini-AQLQ questionnaire. The result of the chi-square test, revealing that 95% of confidence interval; ? = 0.05, where p 0.405 (p ?) OR 2.216, suggesting that the medical compliance did not affect the quality of life. One can argue that this notion, thereby, signifies the necessity to view the quality of life of patients with asthma as a complex issue from multiple perspective

Pemanfaatan Rempah Tradisional Kunyit Kawasan Teluk Tomini Sebagai Vitamin Herbal dalam Pencegahan Jantung Pada Masyarakat Pentadu Barat, Kabupaten Boalemo, Provinsi Gorontalo

Aterosklerosis merupakan penyebab umum penyakit serebro-kardiovaskular dan merupakan kondisi pembuluh darah bisa kronis. Fungsi mekanistik kurkumin terhadap aterosklerosis sebagian disebabkan oleh efek anti-inflamasi dan anti-oksidatifnya serta penghambatan proliferasi dan migrasi sel otot polos pembuluh darah. Untuk itu, pengabdian dilaksanakan bertujuan untuk meningkatkan peran aktif masyarakat, dalam  program pencegahan penyakit jantung melalui pemanfaatan kunyit yang diolah menjadi serbuk minuman dan makanan. Metode pelaksanaan yang digunakan pada kegiatan ini terdiri atas dua bagian, yaitu Seminar dan Workshop. Seminar tentang pentingnya kunyit dalam menjaga kesehatan jantung disampaikan langsung oleh dosen pembimbing lapangan dan Workshop pembuatan suplemen herbal dipraktikan langsung oleh mahasiswa peserta KKN Profesi kesehatan didampingi langsung oleh dosen pembimbing lapangan serta pembuatan disaksikan langung oleh peserta undangan yang terdiri dari pemerintah desa dan masyarakat. Pembuatan produk herbal minuman herbal frape di praktikan langsung oleh tamu undangan kegiatan. Produk Puding dan Minuman herbal frappe mendapatkan respon positif pada saat disuguhkan kepada undangan. Respon berupa aroma, dan rasa yang baik,serta efek segar yang dirasakan pada saat dikonsumsi. Selain itu Kedua produk ini dapat meningkatkan kesehatan jantung khususnya untuk masyarakat yang bekerja sebagai di waktu cuaca ekstrim seperti nelayan yang merupakan mata pencaharian terbesar didesa pentadu barat, dan dinilai  dapat meningkatkan ekonomi desa, karena kedua produk suplemen herbal ini potensi untuk dijual serta dapat dimasukan dalam program peningkatan gizi masyarakat.

Edukasi Tentang Vaksin Covid-19 Pada Masyarakat Desa Buata, Bone Bolango, Provinsi Gorontalo

The World Health Organization (WHO) has declared COVID-19 as a Global Pandemic so must be handled in accordance with the legislation. Vaccination is the most effective and efficient public health effort in preventing some dangerous infectious diseases. Even though, it is undeniable that there are still many community groups who refuse vaccination due to a lack of public knowledge regarding the Covid-19 vaccine. This community service Program aims to increase public knowledge about Covid-19 through education with leaflets and and direct socialization to the Buata village community, Botupinge District, Bone Bolango Regency. The results of the Service Implementation show that the Buata village community is very interested in the information conveyed about Covid-19. This is indicated by the presence of various questions about what is the definition of a vaccine, what are the types of Covid-19 vaccines, and what are the side effects of the Covid-19 vaccine. This question has been answered properly and clearly so that the community feels satisfied and very enthusiastic during the implementation of community service programme

Gambaran Penggunaan Obat Off-Label Pada Pasien Pediatrik Rawat Inap Di Rumah Sakit

Off-label drugs can be interpreted as drugs that are used not in accordance with drug information, distribution permits and sales licenses from the Marketing Authorization (MA) related to indications, age, dosage, route of administration and contraindications. The use of off-label drugs in children occurs because of incomplete data on pharmacokinetics, pharmacodynamics and side effect of a drug. It is because clinical research in children is quite difficult and not in accordance with research ethics and morals, so it has the potential to cause errors in treatment and unwanted drug reactions. This study aims to describe the use of off-label drugs in hospitalized pediatric patients at RSUD of Dr. M.M Dunda Limboto, Gorontalo District, Gorontalo Province. This is an  observational study using cross sectional design and retrospective data collection. The sampling technique applies a purposive sampling technique with a total of 155 patients who meet the inclusion criteria during the January-June 2020 period. The finding shows that from 155 patient medical records, there are 172 (16,51%) off-label drug used with a total of 1042 drugs. The off-label drugs used in the indication category are 64,53%, the off-label drugs used in dose category are 17,44%, the off-label drugs used in age category are 14,53%, the off-label drugs used in route of administration category are 3,49% and the off-label drugs used in contraindications category are not found. The are the most off-label drugs used in each category, including domperidone (off-label in indications and dose), rhinofed (off-label in age) and salbutamol (off-label in route of administration)

Edukasi Tentang Vaksinasi Covid-19 Pada Kalangan Mahasiswa dalam Program Apoteker Selalu Terpecaya Untuk Kesehatan Anda di Jurusan Farmasi, FOK, UNG

Vaksin Covid-19 mulai beredar setelah virus SARS CoV-2 melanda dunia, Pemberian Vaksin Covid- 19 ditujukan untuk meningkatkan kekebalan tubuh manusia dari serangan virus SARS CoV-2. Pro dan Kontra beredar dimasyarakat membuat kegelisahan untuk melaksanakan Vaksin Covid-19. Ikatan Apoteker Indonesia (IAI) melalui Program Apoteker Selalu Terpecaya Untuk Kesehatan Anda, yang dirangkaikan dengan World Pharmacist Day Tahun 2021 diwakili Oleh Apoteker Kota Gorontalo berkunjung di Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo untuk melaksanakan program edukasi vaksin tersebut. Metode edukasi dilaksanakan dengan model pembelajaran langsung, mahasiswa diberikan kuesioner dengan dua tahap, yaitu Pre-Kuesioner dan Post Kuesioner. Materi diberikan setelah Pre-Kuesioner dengan tujuan untuk melihat perbedaan pemahaman setelah diberikan edukasi. Tingkat pemahaman mahasiswa meningkat secara signifikan setelah diberikan edukasi, yaitu dari total presnetasi 30% menjadi 90%. Berdasarkan nilai tersebut, pemberian Edukasi kepada mahasiswa tentang vaksin Covid-19 sangat perlu, untuk mengantisipasi penyerapan informasi vaksin Covid-19 yang berkembang di dunia maya melalui jejaring internet, khususnya melalui media sosial

Profil Kesesuaian Terapi Obat Pada Pasien Dispepsia di Ruangan IGD RSUD dr. Zainal Umar Sidiki

Dyspepsia is an upper gastrointestinal symptom complex that has symptoms of fulllness after eating, early satiety, or epigastric pain of burning without any sturctural cause. The research aims to determine the suitability of drug therapy based on the right patient, the right drug, and the right dose in the emergency room at dr. Zainal Umar Sidiki Regional Public Hospital, North Gorontalo Regency. This research is descriptive research with retrospective data collection. The data used were obtained from medical records of patients in the ER, with 215 patients whose paatient characteristics were processed using the Microsoft Excel program. The results showed that most dyspepsia patients were female, namely 124 (58%), the age range 50-60 years was 74 (34%). The most widely used therapy is combination therapy 154 (72%). The largest variation in the number of single drug uses Inj. Omeprazole amounted to 34 (16%), and a combination of two types of drugs that are widely used, namely Inj. Omeprazole with Inj. Ondansetron has a total of 36 (17%) and a combination of three types of drugs that are widely use, including PPIs, cytoprotectants, and prokinetics, totaling 23 (11%). The rationality of the right patient treatment was 53,48%, the right medicstion was 78%, and the right dose was 100%. In conclusionm the appropriateness of therapy based on the right patient was 53,48%, the right drug was 78%, and the right dose was 100%