Lak phāsā Thai : rīaprīang tām laksūt wichā chut khrū matthayom : tām rabīap wādūai kānsǭp wichā chut khrū Phǭ.Sǭ. 2505 wichā phāsā Thai

พิมพ์ครั้งที่ 16In ThaiIncludes inde

A new furanocoumarin from the fruits of <i>Scaevola taccada</i> and antifungal activity against <i>Pythium insidiosum</i>

<p>A new coumarin, scataccanol (<b>1</b>) and 10 known compounds were isolated from the fruits of <i>Scaevola taccada</i> (Gaertn.) Roxb<i>.</i> All compounds were evaluated for antifungal activity against <i>Pythium insidiosum</i>. Compounds <b>5</b> and <b>7</b> showed strong antifungal activity with minimum inhibitory concentration values of 5 and 10 μg/mL, respectively. Structural determination of all compounds was accomplished by 1D and 2D-NMR, IR and MS.</p

Terpenoids from the Root Bark of <i>Pterolobium macropterum</i>

Five new compounds, including pteroloterins A–C (<b>1</b>, <b>3</b>, and <b>4</b>), 1β-acetoxytaepeenin C (<b>2</b>), and 8aα-hydroxycadinenal (<b>5</b>), and 11 known compounds were isolated from the root bark of <i>Pterolobium macropterum</i>. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compound <b>9</b> showed weak cytotoxicity against the KKU-M139 cell line with an IC₅₀ value of 23.24 ± 0.18 μM and showed no activity against normal cells

A new flavonoid from the leaves of <i>Atalantia monophylla</i> (L.) DC

<p>A new flavonoid, atalantraflavone (<b>1</b>) as well as eight known compounds including atalantoflavone (<b>2</b>), racemoflavone (<b>3</b>), 5,4′-dihydroxy-(3″,4″-dihydro-3″,4″-dihydroxy)-2″,2″-dimethylpyrano-(5″,6″:7,8)-flavone (<b>4</b>), lupalbigenin (<b>5</b>), anabellamide (<b>6</b>), citrusinine I (<b>7</b>), <i>p</i>-hydroxybenzaldehyde (<b>8</b>), and frideline (<b>9</b>), were isolated from the leaves of <i>Atalantia monophylla</i> (L.) DC. Focusing on Alzheimer’s disease, acetylcholine esterase (AChE) inhibition and antioxidant activity were evaluated using the modified Ellman’s method and the ABTS scavenging assay, respectively. It was found that isoflavonoid <b>5</b>, lupalbigenin, showed 79% inhibition to AChE and was 1.4-fold stronger than the tacrine standard. In addition, acridone <b>7</b>, citrusinine I, displayed 90.68% antioxidant activity.</p