62 research outputs found
Reunion of random walkers with a long range interaction: applications to polymers and quantum mechanics
We use renormalization group to calculate the reunion and survival exponents
of a set of random walkers interacting with a long range and a short
range interaction. These exponents are used to study the binding-unbinding
transition of polymers and the behavior of several quantum problems.Comment: Revtex 3.1, 9 pages (two-column format), 3 figures. Published version
(PRE 63, 051103 (2001)). Reference corrections incorporated (PRE 64, 059902
(2001) (E
Luttinger model approach to interacting one-dimensional fermions in a harmonic trap
A model of interacting one--dimensional fermions confined to a harmonic trap
is proposed. The model is treated analytically to all orders of the coupling
constant by a method analogous to that used for the Luttinger model. As a first
application, the particle density is evaluated and the behavior of Friedel
oscillations under the influence of interactions is studied. It is found that
attractive interactions tend to suppress the Friedel oscillations while strong
repulsive interactions enhance the Friedel oscillations significantly. The
momentum distribution function and the relation of the model interaction to
realistic pair interactions are also discussed.Comment: 12 pages latex, 1 eps-figure in 1 tar file, extended Appendix, added
and corrected references, new eq. (53), corrected typos, accepted for PR
A Unified Algebraic Approach to Few and Many-Body Correlated Systems
The present article is an extended version of the paper {\it Phys. Rev.} {\bf
B 59}, R2490 (1999), where, we have established the equivalence of the
Calogero-Sutherland model to decoupled oscillators. Here, we first employ the
same approach for finding the eigenstates of a large class of Hamiltonians,
dealing with correlated systems. A number of few and many-body interacting
models are studied and the relationship between their respective Hilbert
spaces, with that of oscillators, is found. This connection is then used to
obtain the spectrum generating algebras for these systems and make an algebraic
statement about correlated systems. The procedure to generate new solvable
interacting models is outlined. We then point out the inadequacies of the
present technique and make use of a novel method for solving linear
differential equations to diagonalize the Sutherland model and establish a
precise connection between this correlated system's wave functions, with those
of the free particles on a circle. In the process, we obtain a new expression
for the Jack polynomials. In two dimensions, we analyze the Hamiltonian having
Laughlin wave function as the ground-state and point out the natural emergence
of the underlying linear symmetry in this approach.Comment: 18 pages, Revtex format, To appear in Physical Review
Localization of the human Chromosome 5q genes Gabra-1, Gabrg-2, Il-4, Il-5 , and Irf-1 on mouse Chromosome 11
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46991/1/335_2004_Article_BF00350629.pd
Mouse Chromosome 11
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46996/1/335_2004_Article_BF00648429.pd
Whole-genome sequencing reveals host factors underlying critical COVID-19
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Identifying distress among general practitioners: Predictors of psychological ill-health and job dissatisfaction
This paper attempts to identify sources of job stress and personality factors as predictors of psychological ill-health and job dissatisfaction among a large sample of general practitioners in the United Kingdom. Compared to a normative sample, male doctors exhibit significantly higher levels of anxiety and depression, whereas female doctors compare favourably to the population norms. Job satisfaction levels were significantly lower than when they were measured in 1987, although women were less job dissatisfied than men. The main predictors of lack of mental well-being were the job stressors associated with the 'demands of the job and patients' expectation', 'practice administration and routine medical work', 'role stress' and the use of 'social support' as a coping strategy.job stress personality general practitioners mental health job satisfaction stressor predictors gender differences coping styles stress management strategies
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