Using Qualitative Evidence to Enhance an Agent-Based Modelling System for Studying Land Use Change

This paper describes and evaluates a process of using qualitative field research data to extend the pre-existing FEARLUS agent-based modelling system through enriching its ontological capabilities, but without a deep level of involvement of the stakeholders in designing the model itself. Use of qualitative research in agent-based models typically involves protracted and expensive interaction with stakeholders; consequently gathering the valuable insights that qualitative methods could provide is not always feasible. At the same time, many researchers advocate building completely new models for each scenario to be studied, violating one of the supposed advantages of the object-oriented programming languages in which many such systems are built: that of code reuse. The process described here uses coded interviews to identify themes suggesting changes to an existing model, the assumptions behind which are then checked with respondents. We find this increases the confidence with which the extended model can be applied to the case study, with a relatively small commitment required on the part of respondents.Agent-Based Modelling, Land Use/Cover Change, Qualitative Research, Interdisciplinary Research

The Drosophila anatomy ontology.

BACKGROUND: Anatomy ontologies are query-able classifications of anatomical structures. They provide a widely-used means for standardising the annotation of phenotypes and expression in both human-readable and programmatically accessible forms. They are also frequently used to group annotations in biologically meaningful ways. Accurate annotation requires clear textual definitions for terms, ideally accompanied by images. Accurate grouping and fruitful programmatic usage requires high-quality formal definitions that can be used to automate classification and check for errors. The Drosophila anatomy ontology (DAO) consists of over 8000 classes with broad coverage of Drosophila anatomy. It has been used extensively for annotation by a range of resources, but until recently it was poorly formalised and had few textual definitions. RESULTS: We have transformed the DAO into an ontology rich in formal and textual definitions in which the majority of classifications are automated and extensive error checking ensures quality. Here we present an overview of the content of the DAO, the patterns used in its formalisation, and the various uses it has been put to. CONCLUSIONS: As a result of the work described here, the DAO provides a high-quality, queryable reference for the wild-type anatomy of Drosophila melanogaster and a set of terms to annotate data related to that anatomy. Extensive, well referenced textual definitions make it both a reliable and useful reference and ensure accurate use in annotation. Wide use of formal axioms allows a large proportion of classification to be automated and the use of consistency checking to eliminate errors. This increased formalisation has resulted in significant improvements to the completeness and accuracy of classification. The broad use of both formal and informal definitions make further development of the ontology sustainable and scalable. The patterns of formalisation used in the DAO are likely to be useful to developers of other anatomy ontologies

Proinflammatory Markers in Prediction of Posttraumatic Psychological Symptoms: A Prospective Cohort Study

Introduction. Posttraumatic psychopathology (PTP) describes the spectrum of conditions that can complicate the recovery from commonly occurring musculoskeletal trauma. There is a clear association with the activation of the hypothalamic-pituitary-adrenal axis (HPAA), and we wished to examine the predictive value of proinflammatory markers of the HPAA and of the GABA, which acts as an inhibitory regulator. Methods. Levels of proinflammatory markers and GABA were measured in 84 patients who had suffered musculoskeletal injuries requiring hospitalisation. PTP was assessed by the use of the General Health Questionnaire (GHQ) at presentation and again at two- and six-month reviews. Results. Significant psychological disturbance was noted in 39% of patients at two months and falling back to 18% by six months. There was no correlation between any of the markers tested at presentation and PTP at follow-up. Discussion. The HPAA response to trauma and the development of PTP are extremely complex. It is unlikely that a simple blood assay will provide significant predictive information, while incident specific information and patient perception are of more practical use

The paradox of managing autonomy and control

Managers are frequently offered conflicting advice as to how to increase organisational success. One of these complex dilemmas is whether to grant employees autonomy, which may lead to self-management and empowerment or alternatively, exercise control which may enable managers to retain a well-focussed and goal driven workforce. This research focuses on the key factors that influence the various combinations of autonomy and control and their respective outcomes. Qualitative exploratory research was conducted using in-depth interviews with 16 leading South African management and Human Resource experts to uncover their insights regarding this dilemma. The findings suggest that combinations of autonomy and control can co-exist. Management are able to create environments with high levels of autonomy whilst simultaneously retaining high levels of monitoring and oversight when the management control is indirect. It was found that the seemingly contradictory practices of autonomy versus control are a paradox, not a dilemma. Seventeen factors were identified that influence the different levels of autonomy and control in organisations.http://www.journals.co.za/ej/ejour_busman.htmlam2013ff201

Selinexor-Based Triplet Regimens in Patients With Multiple Myeloma Previously Treated With Anti-CD38 Monoclonal Antibodies

High-risk; Oral selective inhibitor of nuclear export; Relapsed/refractoryAlto riesgo; Inhibidor selectivo oral de la exportación nuclear; Recaída/refractarioAlt risc; Inhibidor selectiu oral de l'exportació nuclear; Recaiguda/refractariBackground The increasing use of anti-CD38 monoclonal antibodies (αCD38 mAbs) for newly diagnosed or early relapsed multiple myeloma (MM), especially in non-transplant eligible patients, may lead to more patients developing αCD38 mAb-refractory disease earlier in the treatment course with fewer treatment options. Patients and methods We analyzed the efficacy and safety of selinexor-based triplets (selinexor+dexamethasone [Sd] plus pomalidomide [SPd, n = 23], bortezomib [SVd, n = 16] or carfilzomib (SKd, n = 23]) in a subset of STOMP (NCT02343042) and BOSTON (NCT03110562) study patients treated previously with αCD38 mAbs. Results Sixty-two patients (median 4 prior therapies, range 1 to 11, 90.3% refractory to αCD38 mAb) were included. Overall response rates (ORR) in the SPd, SVd and SKd cohorts were 52.2%, 56.3%, and 65.2%, respectively. Overall response rate was 47.4% among patients who had MM refractory to the third drug reintroduced in the Sd-based triplet. Median progression-free survival in the SPd, SVd, and SKd cohorts was 8.7, 6.7, and 15.0 months, respectively, and median overall survival was 9.6, 16.9, and 33.0 months, respectively. Median time to discontinuation in the SPd, SVd, and SKd cohorts was 4.4, 5.9, and 10.6 months, respectively. The most common hematological adverse events were thrombocytopenia, anemia, and neutropenia. Nausea, fatigue, and diarrhea were primarily grade 1/2. Adverse events were generally manageable with standard supportive care and dose modifications. Conclusion Selinexor-based regimens may offer effective and well-tolerated therapy to patients with relapsed and/or refractory MM who had disease previously exposed or refractory to αCD38 mAb therapy and could help address the unmet clinical need in these high-risk patients

Effect of caffeine on the acceptability of novel flavoured drinks.

Background: Research on the behavioural effects of caffeine is well documented and reviewed. One area rarely covered in the reviews is the effects of caffeine on the acceptability of novel drinks. Findings from such studies have been used to support the view that caffeine deprivation, and its reversal by the ingestion of caffeine, is a major mechanism underlying behavioural changes associated with caffeine. Methods: The present study continued this research on the repeated pairing of novel flavours with caffeine or placebo in groups differing in level of regular caffeine consumption (non-consumers, low consumers, and high consumers). Three groups of volunteers were recruited: non-consumers of caffeine (N=23); low consumers (300mg/day; N=33). After abstaining from caffeine overnight, the volunteers visited the laboratory at 09.00 and consumed a fruit juice with either caffeine (100 mg) or placebo. The caffeine manipulation was double-blind. Participants rated the pleasantness of the drink after their initial taste and after they had consumed it. Two hours later, they returned to the laboratory and repeated the procedure with a fruit tea being consumed, again with or without caffeine. The procedure was repeated for five consecutive days. Results: The analysis of the fruit juice data showed that drink acceptability increased over days and decreased when caffeine was added to the drink. There were no interactions with consumer status. Similar results were found for the ratings of the fruit tea. In addition, those who had caffeine in the fruit juice rated the fruit tea as more acceptable. Again, there were no interactions with consumer status. Conclusion: These results do not confirm the previous finding that caffeine-deprived participants develop a dislike for novel drinks not paired with caffeine, nor that caffeine increases the liking of a novel drink consumed by caffeine-deprived individuals. Rather the results suggest that the taste of caffeine reduces the acceptability of the current drink and leads to an increased liking of a subsequent drink due to the contrast with the previous one

A review and comparative study of release coatings for optimised abhesion in resin transfer moulding applications

In this study, a number of abhesion promoting coatings were considered in terms of their physicochemical and release properties. The techniques used to further this study include; FEGSEM, AFM, profilometry, AFM, XPS, AES, SSIMS, FTIR and contact angle analysis for coating physical and chemical characterisation along with PF-AFM and other adhesion and mechanical tests to determine surface release properties. These coatings were applied to metal substrates and were based upon silicone, fluoropolymer or metal-PTFE composite chemistry, all being potentially useful as release films for resin transfer moulding (RTM) applications. The semi-permanent Frekote B15/710 NC mould release coating system, which is based on PDMS, proved extremely effective in terms of release against a cured epoxide applied under pressure. Although fluoroalkylsilane coatings offer a number of technological advantages for release applications they generally produce very thin coatings which conform any existing surface topography and adhesion through mechanical interlocking occurs. The commercial PTFE-based coatings were found to provide poor release properties due to the presence of surface microcracks which allowed epoxide penetration when cured under elevated pressure and temperature. Electroless Ni/PTFE composite coatings comprise hard nickel-phosphorus matrix containing a very fine dispersion of PTFE particles. The matrix proved sufficiently robust for industrial applications and the low friction and surface energy provided by the embedded PTFE combined with macroscopic scale surface roughness provided efficient mould release

Climate outlooks serving agriculture

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The WARPS Survey: VI. Galaxy Cluster and Source Identifications from Phase I

We present in catalog form the optical identifications for objects from the first phase of the Wide Angle ROSAT Pointed Survey (WARPS). WARPS is a serendipitous survey of relatively deep, pointed ROSAT observations for clusters of galaxies. The X-ray source detection algorithm used by WARPS is Voronoi Tessellation and Percolation (VTP), a technique which is equally sensitive to point sources and extended sources of low surface brightness. WARPS-I is based on the central regions of 86 ROSAT PSPC fields, covering an area of 16.2 square degrees. We describe here the X-ray source screening and optical identification process for WARPS-I, which yielded 34 clusters at 0.06<z<0.75. Twenty-two of these clusters form a complete, statistically well defined sample drawn from 75 of these 86 fields, covering an area of 14.1 square degrees, with a flux limit of F (0.5-2.0 keV) = 6.5 \times 10^{-14} erg cm^{-2} s^{-1}}. This sample can be used to study the properties and evolution of the gas, galaxy and dark matter content of clusters, and to constrain cosmological parameters. We compare in detail the identification process and findings of WARPS to those from other recently published X-ray surveys for clusters, including RDCS, SHARC-Bright, SHARC-south and the CfA 160 deg$^2$ survey.Comment: v3 reflects minor updates to tables 2 and