8 research outputs found
Possible Long-Term Efficacy of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, for Slowly Progressive Type 1 Diabetes (SPIDDM) in the Stage of Non-Insulin-Dependency: An Open-Label Randomized Controlled Pilot Trial (SPAN-S)
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Correction: A Genome-Wide Association Study for Diabetic Retinopathy in a Japanese Population: Potential Association with a Long Intergenic Non-Coding RNA
<p>Correction: A Genome-Wide Association Study for Diabetic Retinopathy in a Japanese Population: Potential Association with a Long Intergenic Non-Coding RNA</p
Regional association plot of the region around the SNP rs9362054.
<p>The -log<sub>10</sub>P values of the Fisher's exact test under the allele model in the GWAS of diabetic retinopathy in stage 1 were plotted against relative chromosomal locations (UCSC human genome 19).</p
Associations of rs9362054 in <i>RP1-90L14.1</i> with diabetic retinopathy (DR), proliferative diabetic retinopathy (PDR) and diabetic nephropathy (DN) in each stage and combined stages 1, 2 and 3, using logistic regression under genotype, dominant and recessive models after adjusting for sex, duration of diabetes and HbA1c.
a<p>With additive genetic effect.</p><p>Associations of rs9362054 in <i>RP1-90L14.1</i> with diabetic retinopathy (DR), proliferative diabetic retinopathy (PDR) and diabetic nephropathy (DN) in each stage and combined stages 1, 2 and 3, using logistic regression under genotype, dominant and recessive models after adjusting for sex, duration of diabetes and HbA1c.</p
Clinical features of Japanese patients with type 2 diabetes.
<p>DR: diabetic retinopathy, PDR: proliferative diabetic retinopathy; DN: diabetic nephropathy, SMU: Saitama Medical University Hospital, SSI: Saitama Social Insurance Hospital, KU: Keio University Hospital, NCGM: National Center for Global Health and Medicine Center Hospital.</p><p>Data are % or mean +− SD.</p>a<p><i>P</i><0.05 vs patients without DR.</p><p>Clinical features of Japanese patients with type 2 diabetes.</p
SNPs showing associations with diabetic retinopathy (DR) in combined stages 1 and 2 samples with <i>P</i><10<sup>−3</sup> using the allele model.
<p>SNPs showing associations with diabetic retinopathy (DR) in combined stages 1 and 2 samples with <i>P</i><10<sup>−3</sup> using the allele model.</p
Manhattan plot for the GWAS of diabetic retinopathy in stage 1.
<p><i>P</i> values of the Fisher's exact test under the allele model for SNPs in 446 patients were shown.</p