Corrigendum: The P4 Study: Postpartum Maternal and Infant Faecal Microbiome 6 Months After Hypertensive Versus Normotensive Pregnancy(Front. Cell. Infect. Microbiol., (2022), 12, (646165), 10.3389/fcimb.2022.646165)

In the original article within Discussion, paragraph 6, sentence 4, the incorrect citation of “Getahun et al., 2017” was used instead of the correct citation “Maher et al., 2018” and the word “preeclampsia” was used instead of “hypertensive disorder”. The corrected sentence reads: “Wang et al. found increased Sutterella species in children who went on to develop autism spectrum disorder (Wang et al., 2013) and a meta-analysis performed by Maher et al. showed a 35% increase in the odds of having a child with autism in hypertensive disorder exposed pregnancies (Maher et al., 2018)”. The full reference for “Getahun et al., 2017” has been removed from the reference list andreplaced with “Maher, G. M., O’Keeffe, G. W., Kearney, P. M., Kenny, L. C., Dinan, T. G., Mattsson, M., et al. (2018). Association of Hypertensive Disorders of Pregnancy With Risk ofNeurodevelopmental Disorders in Offspring: A Systematic Review and Meta-analysis. JAMA psychiatry, 75(8), 809–819. https://doi.org/10.1001/jamapsychiatry.2018.0854”.The authors apologize for this error and state that this does not change the scientific conclusionsof the article in any way. The original article has been updated. In the original article, there was an error in the spelling of several bacterial names which mayimpair the clear interpretation of findings A correction to the spelling of Barnesiella and Bifidobacterium sp. has beenmadeto Abstract, sub-sectionResults, sentence 8.Theupdated sentence reads: “It was also found that at a genus and species level, the gut microbiota of HP women was enriched with Bifidobacterium and Bifidobacterium sp. and depleted in Barnesiella and Barnesiella intestinihominis when compared to NP women (P > 0.05)”. A correction to the spelling of Bifidobacterium sp. has been made to Results, sub-section Changes in Gut Microbiota Composition Between Women After HP and NP, sentence 3. The updated sentence reads: “The gut microbiota of HP women was enriched in phylum Actinobacteria, order Bifidobacteriales, family Bifidobacteriaceae, genus Bifidobacterium and species Bifidobacterium sp. compared to NP women (LDA > 2, P > 0.05)”. A correction to the spelling of Streptococcus infantis has been made to Discussion, paragraph 6, sentence 1. The updated sentence reads: “In this study, one enriched species of bacteria from the Firmicutes phylum, Streptococcus infantis was found in the infants born from HP mothers”.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated

The P4 Study: Postpartum Maternal and Infant Faecal Microbiome 6 Months After Hypertensive Versus Normotensive Pregnancy

Objective/Hypothesis: To explore potential differences in faecal microbiome between women, and their infants, who had normotensive pregnancies (NP) and those who had a hypertensive pregnancy (HP), either gestational hypertension (GH) or preeclampsia (PE). Methods: This is a sub study of P4 (Postpartum Physiology, Psychology, and Paediatrics Study) and includes 18 mother-infant pairs: 10 NP and 8 HP (HP as defined by blood pressure > 140/90mmHg; of which 6 had PE, and 2 GH), six months postpartum. The participating mothers collected stool samples from themselves and their infants. 16S rRNA V3-V4 amplicons were used to study the faecal microbiome. Results: The sample of women and their infants were mostly primiparous (n =16) with vaginal birth (n = 14). At the time of faecal sampling 8 women were using hormonal contraception, and one HP woman remained on an antihypertensive. All women had blood pressure 30). All infants had started solids, 8 were exclusively breastfed, 1 exclusively formula fed and 9 both. Three infants had been exposed to a course of antibiotics. Six months postpartum, there were no significant differences in alpha or beta diversity between the gut microbiota of HP and NP women (P > 0.05). However, a statistically significant difference was detected in alpha diversity between infants following HP and NP, with lower diversity levels in HP infants (P < 0.05). It was also found that at a genus and species level, the gut microbiota of HP women was enriched with Bifidobacterium and Bifididobacterium sp. and depleted in Barnisiella and Barnesiella intestinihominis when compared to NP women (P < 0.05). Similarly, the gut microbiota of infants born from HP was enriched in Streptococcus infantis and depleted in Sutterella, Sutterella sp., Bacteroides sp. and Clostridium aldenense compared to infants born from NP (P < 0.05). Discussion: While our findings are at best preliminary, due to the very small sample size, they do suggest that the presence of hypertension in pregnancy may adversely affect the maternal microbiota postpartum, and that of their infants. Further analysis of postpartum microbiome data from future studies will be important to validate these early findings and provide further evidence about the changes in the microbiota in the offspring of women following hypertensive disorders of pregnancy (HDP), including possible links to the causes of long-term cardiovascular disease, the prevalence of which is increased in women who have experienced HDP