EVALUASI PENGGUNAAN OBAT ANTIHIPERTENSI ACE INHIBITOR LISINOPRIL TERHADAP KEJADIAN BATUK KERING PADA PASIEN HIPERTENSI DI KOMUNITAS GEREJA DI KABUPATEN MALANG

Latar belakang: Lisinopril adalah obat antihipertensi dari golongan obat angiotensin converting enzyme inhibitor (ACEi) yang dapat memiliki efek samping batuk kering. Tujuan: Penelitian ini memiliki tujuan untuk memberikan menilai resiko pada penggunaan obat golongan ACE inhibitor yang menimbulkan batuk kering pada pasien hipertensi di lingkup gereja. Metode: Desain penelitian ini analitic case control. Kriteria inklusi adalah pasien hipertensi yang menggunakan obat golongan ACE inhibitor >3 bulan, rentang umur 35-60. Subjek terdiri dari 49 pasien yang menggunakan Lisinopril (ACE inhibitor) dan 49 pasien yang tidak menggunakan Lisinopril (Non-ACE inhibitor) yang diambil secara nonprobability sampling pada bulan April-Mei 2020. Alat pengumpulan data menggunakan wawancara terstruktur dan kuesioner. Kejadian batuk kering akibat dievaluasi menggunakan Algoritma Naranjo. Data dianalisis menggunakan analisis univariat, bivariat, dan multivariat. Simpulan dan saran: Hasil menunjukkan penggunaan ACE inhibitor memiliki hubungan yang bermakna pada faktor usia, pekerjaan, dan riwayat merokok. Responden dengan usia 46-50 tahun dan Ibu rumah tangga  memiliki resiko kejadian batuk kering lebih kecil 0,8 (p= 0,035, 95%; CI= 0,004-0,817) dan 2,78 (p= 0,016, 95%; CI= 1,51-57,65) kali dibandingkan dengan responden Non ACE inhibitor. Sedangkan responden dengan riwayat tidak merokok memiliki resiko kejadian batuk kering empat kali lebih besar pada pengobatan dengan ACE inhibitor (p= 0,043, 95%; CI= 1,00-8,00)

Aromatherapeutic Antibacterials: Comparative Study of 40 Essential Oils and Their Biofilm Inhibition in Pseudomonas aeruginosa ATCC9027

Growing evidence suggests that biofilm formation in Pseudomonas aeruginosa (PA) results from quorum sensing, reducing bacterial sensitivity to antibiotics and fostering the development of antibiotic-resistant strains. Addressing the need for a compound that can inhibit quorum sensing signals to mitigate biofilm formation in PA, this study screened 40 essential oils for their potential as quorum sensing inhibitors against PA ATCC9027. Utilizing the agar well diffusion assay, the antibacterial activity of these essential oils was compared with levofloxacin, revealing that 25 out of 40 essential oils exhibited antibacterial activity against PA ATCC9027. The highest antibacterial activity was exhibited by essential oils from Cinnamomum burmannii (Cinnamon Bark Oil), Cananga odorata (Ylang-ylang Oil), and Eucalyptus globulus (Eucalyptus Oil), confirmed by respective MIC values of 0.09765% (v/v), 0.390625% (v/v), and 1.5625% (v/v), and MBC values of 0.09765% (v/v), > 1.5625% (v/v), and > 1.5625% (v/v). Growth curve inhibition assay followed by crystal violet biofilm formation assay revealed that only Ylang-ylang Oil exhibited biofilm formation inhibition at 1/4 MIC concentration. Docking analysis of compounds from these essential oils against quorum sensing enzymes (LasR, PqsR, and QscR) revealed that Ylang-ylang Oil compounds exhibited the highest binding affinity. In conclusion, among the 40 essential oils tested, 25 show potential as antibacterials against PA ATCC9027, with Ylang-ylang Oil standing out as a promising candidate for quorum sensing inhibitor development. The use and development of quorum sensing inhibitors from Ylang-ylang Oil compounds are expected to reduce the burden of antibiotic resistance, especially in Pseudomonas aeruginosa

Pelatihan Dan Pengembangan Resep Produk Minuman Jeruk Instan Guna Meningkatkan Perekonomian Masyarakat

Kucur Village is a tangerine producer in Malang Regency. However, people still sell it in fresh fruit form; besides that, the pest of fruit flies is also a scourge for farmers, and the absorption capacity in the market for fresh fruit is still relatively lower than the products produced. Processing oranges into secondary products can be a solution for farmers by processing tangerines. Ma Chung University's service aims to develop recipes for making instant powder drinks from tangerines to increase the tangerines' economic value. The method used is recipe development in the laboratory, which is practised in Kucur Village to find which recipe is most suitable and produce products for sale. The results of this service and the Kucur village community produced a recipe suitable for sale as an instant powder drink. The recipe for this instant powder drink contains an infusion of lemongrass stems, ginger, bay leaves, and lime