Changes in Effective Connectivity of the Superior Parietal Lobe during Inhibition and Redirection of Eye Movements

Executive control is the ability to flexibly control behavior and is frequently studied with saccadic eye movements. Contrary to frontal oculomotor areas, the role of the superior parietal lobe (SPL) in the executive control of saccades remains unknown. To explore the role of SPL networks in saccade control, we performed a saccadic search-step task while acquiring functional magnetic resonance imaging data for 41 participants. Psychophysiological interaction analyses assessed task-related differences in the effective connectivity of SPL with other brain regions during the inhibition and redirection of saccades. Results indicate an increased coupling of SPL with frontal, posterior, and striatal oculomotor areas for redirected saccades versus visually guided saccades. Saccade inhibition versus unsuccessful inhibition revealed an increased coupling of SPL with dorsolateral prefrontal cortex and anterior cingulate cortex. We discuss how these findings relate to ongoing debates about the implementation of executive control and conclude that early attentional control and rapid updating of saccade goals are important signals for executive control

Classroom peer preferences and the development of sharing behavior with friends and others

This study examined the sex-specific developmental trajectories of sharing behavior in the Dictator Game with an anonymous other, best friend, and disliked peer and associations with peer likeability and peer dislikeability in 1,108 children (50.5% boys) followed annually across grades 2–6 (ages 8–12) of elementary school. Results showed that sharing with an anonymous other and disliked peer remained stable over time. Sharing with a best friend decreased slightly between grades 2 and 5 and then remained stable. Girls consistently shared more with all recipients than boys. Moreover, children who were liked by classmates shared more with a best friend, while disliked children shared less with all recipients. Findings emphasize the importance of considering characteristics of both recipient and actor when studying the development of sharing behavior

Erratum:Heightened neural sensitivity to social exclusion in boys with a history of low peer preference during primary school (Developmental Cognitive Neuroscience (2019) 38, (S1878929318302676), (10.1016/j.dcn.2019.100673))

Contains fulltext : 221380.pdf (publisher's version ) (Open Access)Peer preference among classmates is a highly influential factor in children's social development and not being preferred by peers has long-term consequences for children's developmental outcomes. However, little is known about how a history of low peer preference during primary school is associated with neural responses to a new social exclusion experience in childhood. In this functional magnetic resonance imaging (fMRI) study, we examined self-reported social distress and neural responses to social exclusion using the Cyberball paradigm in primary school boys (Mage = 10.40 years) with a history of low (n = 27) versus high peer preference (n = 28). Boys were selected from a longitudinal classroom-based study in which children’s peer social preferences were assessed in three consecutive years prior to this study. Neuroimaging results showed that low peer preferred boys exhibited increased activation in the lateral prefrontal cortex during early social exclusion relative to later social exclusion experiences as compared to high peer preferred boys. Increased neural activity was not accompanied by higher self-reported levels of social distress during social exclusion in low versus high peer preferred children. Findings of this study may provide insight into the neural processes associated with real-life peer experiences in children attending primary school.10 p

Associations between peer attachment and neural correlates of risk processing across adolescence

Contains fulltext : 225251.pdf (publisher's version ) (Open Access)Adolescence is a period of increased risk-taking behavior where individual differences in risk taking may relate to both adverse and positive experiences with peers. Yet, knowledge on how risk processing develops in the adolescent brain and whether this development is related to peer attachment is limited. In this longitudinal functional magnetic resonance imaging (fMRI) study, we collected data from 167 adolescents (53% male) followed for four annual assessments across ages 13-17 years. At each assessment, participants completed a lottery choice task to assess neural risk processing and reported on their perceived attachment to peers and parents. Behaviorally, risk-preference on the lottery choice task decreased linearly with age. Neural activation during risk processing was consistently found in the insula and dACC across the four assessments and increased linearly from ages 13-17 years. Furthermore, higher peer attachment was related to greater right insula risk processing for males but not for females, even after controlling for parental attachment. The magnitudes of this association did not change with age. Findings demonstrate that neural risk processing shows maturation across adolescence and high peer attachment may be associated with low risk taking by heightening neural sensitivity to potential risks for male adolescents.11 p

Increasing incidence of ED-visits and admissions due to traumatic brain injury among elderly patients in the Netherlands, 2011–2020

Background and importance: Traumatic brain injury (TBI) is a leading cause of disability and mortality worldwide. Nowadays the highest combined incidence of TBI-related emergency department (ED) visits, hospitalizations and deaths occurs in older adults. Knowledge of the changing patterns of epidemiology is essential to identify targets to enhance prevention and management of TBI. Objective: To examine time trends of ED visits, admissions, and mortality for TBI comparing non-elderly and elderly people (aged ≥ 65 years) in the Netherlands from 2011 to 2020. Design: We conducted a retrospective observational, longitudinal study of TBI using data from the Dutch Injury Surveillance System (DISS) and Statistics Netherlands from 2011 to 2020. Outcome measure and analysis: The main outcome measures were TBI-related ED visits, hospitalizations, and mortality. Temporal trends in population-based incidence rates were evaluated using Poisson regression. We compared patients under 65 years and patients aged 65 years or older. Main results: From 2011 to 2020, absolute numbers of TBI related ED visits increased by 244%, and hospital admissions and mortality showed an almost twofold increase in patients aged 65 years and older. The incidence of TBI-related ED visits and hospital admission increased also in elderly adults, with 156% and 51% respectively, whereas the mortality remained stable. In contrast, overall rates of ED visits, admissions, and mortality, and causes for TBI did not change in patients younger than 65 years during the study period. Conclusion: This trend analysis shows a significant increase of ED-visits and hospital admission for TBI in elderly adults from 2011 to 2020, whereas the mortality remained stable. This increase cannot be explained by the aging of the Dutch population alone, but might be related to comorbidities, causes of injury, and referral policy. These findings strengthen the development of strategies to prevent TBI and improve the organization of acute care necessary to reduce the impact and burden of TBI in elderly adults and on healthcare and society