7 research outputs found
Patterns and frequencies of DNA copy alterations in ALL patients.
<p>(A) Log<sub>2</sub>-ratio copy number heatmap of array-based comparative genomic hybridization (aCGH) data in childhood (left) and adult (right) ALL. (gains: red; losses: blue). (B) Overall frequency of copy number changes in childhood (left) and adult (right) ALL. (gains: red; losses: blue) (C) Regions of significant recurrent amplification and deletion in childhood (left) and adult (right) ALL (q<0.05).</p
Association of DNA/chromosomal aberrations with clinical characteristics in the whole cohort of patients with ALL.
<p>Association of DNA/chromosomal aberrations with clinical characteristics in the whole cohort of patients with ALL.</p
Univariate and multivariate analysis of overall survival in adults with ALL.
<p>Univariate and multivariate analysis of overall survival in adults with ALL.</p
Univariate and multivariate analysis of overall survival in children with ALL.
<p>Univariate and multivariate analysis of overall survival in children with ALL.</p
Characteristics of patients with ALL included in the study.
<p>Characteristics of patients with ALL included in the study.</p
KaplanâMeier plots demonstrating the effect of copy number changes on overall survival (OS) in children with ALL.
<p>(A) OS of the whole cohort of children with ALL with respect to the presence of deletions in 14q32.33. (B) OS of the whole cohort of children with ALL with respect to the presence of deletions in 15q13.2. (C) OS of the children with ALL without chromosomal abnormalities associated with good-risk (hyperdiploid and t(12;21)) or poor risk (t(9;22), t(v;11q23) and hypodiploidy) with respect to the presence of gains of 1p36.11.</p
KaplanâMeier plots demonstrating the effect of copy number changes on overall survival (OS) in adult patients with ALL.
<p>(A) OS of the whole cohort of adults with ALL with respect to the presence of deletions in 17p. (B) OS of adults without poor-risk with respect to the presence of deletions in 7p12.2. (C) OS of adults with ALL classified in the poor-risk cytogenetic group with respect to the presence of deletions in 3q26.32. NR, not reached.</p