5 research outputs found
Proportion of <i>P.vivax</i> infections diagnosed during 8 consecutive cross-sectional surveys in Remansinho, Brazil, that were symptomatic (black bar segments) and asymptomatic (white bar segments) according to parasite density estimated by quantitative PCR.
<p>The bar widths are proportional to the number of cases within each parasite density class. A total of 129 <i>P. vivax</i> infections were classified according to the presence of symptoms and parasite density.</p
Kaplan-Meier estimates of the proportion of <i>P. vivax</i>-infected (continuous black line) and uninfected (continuous red line) asymptomatic subjects who remained free of slide-confirmed clinical vivax malaria over the follow-up period.
<p>Dashed lines represent the respective 95% confidence intervals. The small vertical tick-marks indicate the occurrence of a slide positive case of <i>P.vivax</i>, corresponding to the right censoring of the individual survival time. A Cox proportional hazards model revealed no significant difference, between the two groups, in overall risk of vivax malaria episodes, after controlling for potential confounders (hazard ratio = 1.07; 95% CI, 0.52–2.22, <i>P</i> = 0.840).</p
Number of malarial infections diagnosed by conventional microscopy (CM) and quantitative real-time PCR (qPCR), according to the presence or absence of malaria-related symptoms, during 8 consecutive cross-sectional surveys in the population of Remansinho, Brazil (2010–13).
<p>Dates of cross-sectional surveys were: survey 1 1, March–May, 2010; survey 2, May–July, 2010; survey 3, October–November, 2010; survey 4, March–April, 2011; survey 5, October–November, 2011; survey 6, April–May, 2012; survey 7, October–November, 2012; survey 8, April–May, 2013. Polyethylene bed-nets treated with 2% permethrin (Olyset Net) were distributed to the entire study population in August, 2012.</p><p>Number of malarial infections diagnosed by conventional microscopy (CM) and quantitative real-time PCR (qPCR), according to the presence or absence of malaria-related symptoms, during 8 consecutive cross-sectional surveys in the population of Remansinho, Brazil (2010–13).</p
Correlation between length of residence in Amazonia (in years), a proxy of cumulative exposure to malaria, and the probability of having a <i>P. vivax</i> infection (continuous red line) and a clinical vivax malaria episode (continuous black line).
<p>Lines represent median individual probabilities derived from the final (fully adjusted) mixed-effects logistic regression models; the shaded area surrounding the lines represent interquartile ranges.</p
Venn diagram showing the proportion of <i>P. vivax</i> infections diagnosed by quantitative PCR during 8 consecutive cross-sectional surveys in Remansinho, Brazil, that were asymptomatic, subpatent (i.e., missed by conventional microscopy) and agametocytemic.
<p>The latter group comprises infections with no <i>pvs25</i> gene transcripts detected by quantitative reverse transcriptase PCR; note that all agametocytemic infections were both asymptomatic and subpatent.</p