The Potential for Resident Lung Mesenchymal Stem Cells to Promote Functional Tissue Regeneration: Understanding Microenvironmental Cues

Tissue resident mesenchymal stem cells (MSCs) are important regulators of tissue repair or regeneration, fibrosis, inflammation, angiogenesis and tumor formation. Bone marrow derived mesenchymal stem cells (BM-MSCs) and endothelial progenitor cells (EPC) are currently being considered and tested in clinical trials as a potential therapy in patients with such inflammatory lung diseases including, but not limited to, chronic lung disease, pulmonary arterial hypertension (PAH), pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD)/emphysema and asthma. However, our current understanding of tissue resident lung MSCs remains limited. This review addresses how environmental cues impact on the phenotype and function of this endogenous stem cell pool. In addition, it examines how these local factors influence the efficacy of cell-based treatments for lung diseases

Bembidion sulcipenne subsp. prasinoides Lindroth 1963

Bembidion sulcipenne prasinoides Lindroth, 1963 NOVA SCOTIA: Colchester Co.: Portapique, 19.vii. 1987, A. Larochelle & M.–C. Larivière, (15, NSMC). Newly recorded in Nova Scotia. Gregarious, found on moist, bare, or gravelly soil along the banks of swift rivers and brooks; nocturnal (Larochelle & Larivière 2003).Published as part of Majka, Christopher G., Bousquet, Yves & Westby, Susan, 2007, The ground beetles (Coleoptera: Carabidae) of the Maritime Provinces of Canada: review of collecting, new records, and observations on composition, zoogeography, and historical origins, pp. 1-36 in Zootaxa 1590 on page 8, DOI: 10.5281/zenodo.27391

Dyschirius larochellei Bousquet 1988

Dyschirius larochellei Bousquet, 1988 Bousquet (1988) described D. larochellei from specimens collected in the United States noting that the range of the species probably (emphasis added) extends north to Newfoundland since the specimens reported by Lindroth (1955) from there as D. erythrocerus LeConte almost certainly referred to this new species. Subsequently Bousquet and Larochelle collected the species in New Brunswick in 1988 (CNC) and it was included in the faunal lists of both New Brunswick and Nova Scotia by Bousquet (1991), Bousquet & Larochelle (1993), and Goulet & Bousquet (2004). However, no specimens from Nova Scotia have actually been collected. Accordingly we remove this species from the faunal list of Nova Scotia.Published as part of Majka, Christopher G., Bousquet, Yves & Westby, Susan, 2007, The ground beetles (Coleoptera: Carabidae) of the Maritime Provinces of Canada: review of collecting, new records, and observations on composition, zoogeography, and historical origins, pp. 1-36 in Zootaxa 1590 on page 7, DOI: 10.5281/zenodo.27391

Bembidion cheyennense Casey 1918

Bembidion cheyennense Casey, 1918 NOVA SCOTIA: Kings Co.: Sheffield Mills, 3.vii. 2000, K. Neil, light-trap, (1, ACNS). Newly recorded in Nova Scotia and in the Maritime Provinces as a whole. Found at the edges of ponds, reservoirs, water holes, riverbanks, and lakeshores; also close to water in cultivated fields and meadows on open or sparsely vegetated ground (Larochelle & Larivière 2003).Published as part of Majka, Christopher G., Bousquet, Yves & Westby, Susan, 2007, The ground beetles (Coleoptera: Carabidae) of the Maritime Provinces of Canada: review of collecting, new records, and observations on composition, zoogeography, and historical origins, pp. 1-36 in Zootaxa 1590 on page 7, DOI: 10.5281/zenodo.27391

Notiophilus semistriatus Say 1823

Notiophilus semistriatus Say, 1823 NEW BRUNSWICK: Albert Co.: 3 km north of Fundy National Park, 4.viii. 1994, black spruce plantation, J. Julian, pitfall trap, (6, NSMC). Newly recorded in New Brunswick. These specimens were collected incidentally in the course of research on amphibians published by Waldick et al. (1999). In Nova Scotia the species is recorded only from Cape Breton Island (C.G. Majka, unpublished data). Found in a large variety of environments on open or half-shaded ground (Larochelle & Larivière 2003). Adults and larvae of Notiophilus prey on Collembola (Ball & Bousquet 2000).Published as part of Majka, Christopher G., Bousquet, Yves & Westby, Susan, 2007, The ground beetles (Coleoptera: Carabidae) of the Maritime Provinces of Canada: review of collecting, new records, and observations on composition, zoogeography, and historical origins, pp. 1-36 in Zootaxa 1590 on page 6, DOI: 10.5281/zenodo.27391

Myas cyanescens Dejean 1828

Myas cyanescens Dejean, 1828 This species was listed as occurring in Nova Scotia by Bousquet & Larochelle (1993), and Goulet & Bousquet (2004). However, there is only one specimen from the Maritime Provinces, collected in Saint Andrews, New Brunswick (CNC). Accordingly we remove this species from the faunal list of Nova Scotia.Published as part of Majka, Christopher G., Bousquet, Yves & Westby, Susan, 2007, The ground beetles (Coleoptera: Carabidae) of the Maritime Provinces of Canada: review of collecting, new records, and observations on composition, zoogeography, and historical origins, pp. 1-36 in Zootaxa 1590 on page 8, DOI: 10.5281/zenodo.27391

Calosoma scrutator Fabricius 1775

Calosoma scrutator (Fabricius, 1775) NOVA SCOTIA: Shelburne Co.: Cape Sable Island: The Hawk, 19.ix. 2002, G. Milroy, coastal meadow: under board, (1, NSMC). Newly recorded in Nova Scotia and in the Maritime Provinces as a whole. The discovery of this specimen on Cape Sable Island, in the extreme southwest of Nova Scotia, is surprising given the absence of records elsewhere in the Maritimes. Although it is unlikely that the species is a permanent resident, it is possible that the mild climate of Cape Sable Island allows a population to persist. Alternatively, the individual may represent a wind-blown stray from New England where this adept flyer occurs. The location of the island (the outermost projection of land into the northern Gulf of Maine) annually attracts many migrant and wind-blown stray birds. Calosoma scrutator is found in a large variety of environments on shaded ground; nocturnal and predaceous on Lepidoptera caterpillars and other insects (Larochelle & Larivière 2003).Published as part of Majka, Christopher G., Bousquet, Yves & Westby, Susan, 2007, The ground beetles (Coleoptera: Carabidae) of the Maritime Provinces of Canada: review of collecting, new records, and observations on composition, zoogeography, and historical origins, pp. 1-36 in Zootaxa 1590 on page 6, DOI: 10.5281/zenodo.27391