Master table of specific features in CM versus COC patients.

<p>CM = cerebral malaria.</p><p>COC = comas of other causes.</p>*<p>includes 13 cases of clinically, but not pathologically, defined CM.</p><p>SD = standard deviation.</p

Photomicrograph of immunohistochemical staining for β-APP in nerve fiber layer.

<p>(Anti-β-APP, hematoxylin counterstain.)</p

Severity of hemorrhages in CM cases based on clinical grading scale^*.

*<p>0 = none.</p><p>1 = 1–5.</p><p>2 = 5–20.</p><p>3 = 20–50.</p><p>4 = 50+.</p><p>CM = cerebral malaria.</p><p>NA = data not available.</p

Figure 5

<p>A. Photomicrograph of retinal hemorrhage with a central vessel containing a thrombus sectioned obliquely (arrow). B. Thrombus in a larger vessel without surrounding hemorrhage. Note that some of the surrounding capillary-sized vessels contain thrombi (arrows) while others do not (arrowhead). C&D. Immunohistochemical staining for fibrin (C), and CD61 to identify platelets (D). (C: Anti-fibrin, hematoxylin counterstain; D: Anti-CD61, hematoxylin counterstain.)</p

Photomicrograph of cystoid macular edema in the outer plexiform layer (arrows).

<p>Photomicrograph of cystoid macular edema in the outer plexiform layer (arrows).</p

Photomicrograph of immunohistochemical staining for fibrinogen surrounding a small vessel (arrowhead) and in the spaces of cystoid macular edema (arrow).

<p>(Anti-fibrinogen, hematoxylin counterstain.)</p

Photomicrograph of retinal vessels showing sequestration of parasitized red blood cells containing late stage parasites.

<p>Photomicrograph of retinal vessels showing sequestration of parasitized red blood cells containing late stage parasites.</p

Fundus photograph displaying malarial retinopathy consisting of multiple white centered hemorrhages, macular whitening (arrowheads) and orange discoloration of vessels (arrow).

<p>Fundus photograph displaying malarial retinopathy consisting of multiple white centered hemorrhages, macular whitening (arrowheads) and orange discoloration of vessels (arrow).</p

Figure 3

<p>A. Representative gross photo of malarial retinopathy showing multiple white-centered hemorrhages. B. Low power photomicrograph of hemorrhages involving all layers of the retina, including beneath the internal limiting membrane as well as subretinal hemorrhage with shallow detachment.</p

MOESM2 of Grading fluorescein angiograms in malarial retinopathy

Additional file 2. Fluorescein angiogram features in 285 subjects with admission angiogram of the left eye, reported by clinical diagnosis. Table of angiographic features in subjects with different diagnoses, with and without observable malarial retinopathy on dilated indirect ophthalmoscopy pre-angiogram