Coinheritance of HbD-Punjab/β+-thalassemia (IVSI+5 G-C) in patient with Gilbert's syndrome

Thalassemia and qualitative hemoglobinopathy are hereditary disorders of Hb synthesis that lead to change in the Hb conformation or a decrease in the synthesis of structurally normal Hb, and consequently, to erythron pathology. Many variants of Hb are unstable or have altered affinity for oxygen, and, in heterozygous form can be associated with clinical and hematological manifestations (hemolytic anemia, hypochromic microcytic anemia, erythrocytosis). HbD-Punjab [β121 (GH4) Glu → Gln; HBB: C.364G> C] is variant of Hb carrying the amino acid substitution in the 121 position of β-globin chain. In all cases reported so far, patients with HbD-Punjab/β+-thalassemia (IVSI+5 G-C) combination experienced typical thalassemia with hypochromic microcytosis. HbD-Punjab was detected by electrophoresis from 37 to 94% of total Hb. The article describes rare clinical case of the cohabitation of HbD-Punjab/β+-thalassemia (IVSI+5 G-C) in a patient with homozygous variant of Gilbert's syndrome observed in AS Loginov Moscow Clinical Scientific Center. © 2018 Media Sphera Publishing Group. All rights reserved

Coinheritance of HbD-Punjab/β+-thalassemia (IVSI+5 G-C) in patient with Gilbert's syndrome

Thalassemia and qualitative hemoglobinopathy are hereditary disorders of Hb synthesis that lead to change in the Hb conformation or a decrease in the synthesis of structurally normal Hb, and consequently, to erythron pathology. Many variants of Hb are unstable or have altered affinity for oxygen, and, in heterozygous form can be associated with clinical and hematological manifestations (hemolytic anemia, hypochromic microcytic anemia, erythrocytosis). HbD-Punjab [β121 (GH4) Glu → Gln; HBB: C.364G> C] is variant of Hb carrying the amino acid substitution in the 121 position of β-globin chain. In all cases reported so far, patients with HbD-Punjab/β+-thalassemia (IVSI+5 G-C) combination experienced typical thalassemia with hypochromic microcytosis. HbD-Punjab was detected by electrophoresis from 37 to 94% of total Hb. The article describes rare clinical case of the cohabitation of HbD-Punjab/β+-thalassemia (IVSI+5 G-C) in a patient with homozygous variant of Gilbert's syndrome observed in AS Loginov Moscow Clinical Scientific Center. © 2018 Media Sphera Publishing Group. All rights reserved

Study of

We present current status of the SND and CMD-3 experiments at the VEPP-2000 e+e− collider and recent result of data analysis on the processes $e^+e^-\rightarrow\pi^+\pi^-,n\overline n,\pi^+\pi^-\eta,\pi^+\pi^-\pi^0\eta,K_SK_L\pi^0$, etc

Study of e+e− annihilation to hadrons at the VEPP-2000 collider

We present current status of the SND and CMD-3 experiments at the VEPP-2000 e+e− collider and recent result of data analysis on the processes e+e−→π+π−,nn¯,π+π−η,π+π−π0η,KSKLπ0$e^+e^-\rightarrow\pi^+\pi^-,n\overline n,\pi^+\pi^-\eta,\pi^+\pi^-\pi^0\eta,K_SK_L\pi^0$, etc

Measurement of the hadronic cross sections with the CMD-3 and SND detectors at the VEPP-2000 collider

Since December 2010 the CMD-3 and SND detectors detectors collect data at the VEPP-2000 electron-positron collider. In 2013-2015 the injection facility of the collider has undergone an upgrade of the injection system. The new BINP injection complex has been connected to the VEPP-2000 collider, so the restrictions connected to the lack of positrons and limited beam energy transfer do not apply any more. The collider luminosity in whole energy range is restricted now only by beam-beam effects. VEPP-2000 collider started to collect data with two detectors at 2016 year. The collected data sample since 2010 corresponds more than 100 pb-1 of integrated luminosity per detector in the c.m. energy between 0.32 and 2GeV. We will report here results of analysis of various hadronic cross sections from detectors both published and preliminary. These measurements are important by themselves and also because of the implications for anomaly of the magnetic moment of a muon (g-2) discrepancy