(E)-3-(4-Chloro­phen­yl)-1-(2,3,4-trichloro­phen­yl)prop-2-en-1-one

In the title chalcone derivative, C15H8Cl4O, the C=C double bond exists in an E configuration and the dihedral angle between the two benzene rings is 48.13 (11)°. In the crystal, mol­ecules are arranged into columns and stacked down the a axis featuring possible weak aromatic π–π stacking inter­actions [centroid–centroid separation = 3.888 (2) Å]

Effect of Fe substitution on the magnetic, transport, thermal and magnetocaloric properties in Ni50Mn38-xFexSb12 Heusler alloys

The structural, magnetic, transport, thermal and magnetothermal properties of quaternary Heusler alloys Ni50Mn38-xFexSb12 have been studied. Powder x-ray diffraction and temperature dependence of magnetization studies reveal that with addition of Fe in Mn site, the martensitic transition shifts to lower temperatures. It is also found that the martensitic transition becomes broader for the higher Fe concentrations. The metamagnetic transition in M(H) isotherms becomes very prominent in x=2 and vanishes for x=3 and 4. A maximum positive magnetic entropy change of 14.2 J/kg K is observed for x=2 at 288 K for 50 kOe. Resistivity shows an abrupt decrease across the martensitic transition in all the alloys, except x=6, which does not have the martensitic transition. Maximum negative magnetoresistance of 21% has been obtained for x=2 at 50 kOe. The same alloy also shows an exchange bias field of 288 Oe.Comment: 28 pages, 10 figures, This paper is accepted to be published in Journal of Applied Physic

Automated Identification of Oceanic Fronts for Operational Generation of Potential Fishing Zone (PFZ) Advisories

PFZs, are essentially the frontal structures as identified from the satellite images of Sea Surface Temperature (SST) and chlorophyll concentration. These regions are known for fish aggregation and provide cost-effectiveness in offshore fishing operations. Subjective identification of fronts may lead to human-errors, non-negotiable beyond a limit. To overcome this, we propose utilization of tools that help automated identification of the frontal structures. This approach not only removes the errors, but also helps shorten the time period of the operational process-chai

4-Meth­oxy­benzaldehyde (5-bromo­pyrimidin-2-yl)hydrazone monohydrate

In the title Schiff base compound, C12H11BrN4O·H2O, the organic mol­ecule exists in an E configuration with respect to the C=N double bond. The pyrimidine ring is approximately planar, with a maximum deviation of 0.011 (2) Å, and forms a dihedral angle of 10.68 (8)° with the benzene ring. In the crystal, inter­molecular O—H⋯N, N—H⋯O and C—H⋯O hydrogen bonds link the mol­ecules into a two-dimensional network parallel to the ac plane

4-[4-Eth­oxy­carbonyl-5-(3,4-methyl­ene­dioxy­phen­yl)-3-oxocyclo­hex-1-en-1-yl]-3-phenyl­sydnone

In the title compound {systematic name: 4-[4-eth­oxy­carbonyl-5-(3,4-methyl­ene­dioxy­phen­yl)-3-oxocyclo­hex-1-en-1-yl]-3-phenyl-1,2,3-oxadiazol-3-ium-5-olate}, C24H20N2O7, the cyclo­hexene and dioxole rings adopt envelope conformations. The sydnone ring and the attached phenyl ring form a dihedral angle of 79.0 (1)°. In the mol­ecular structure, a C—H⋯O hydrogen bond generates an S(6) ring and a C—H⋯π inter­action involving the phenyl ring is observed. In the crystal structure, mol­ecules are linked into a ribbon-like structure along the a axis by C—H⋯O hydrogen bonds

Clinical skill learning for tomorrow’s doctors - a step towards better obstetric care

Background: Female urethral catheterization is the most commonly performed procedure in obstetrics and gynecology, for the assessment of urinary output. Many times catheterization is done by junior colleagues with improper technique resulting in improper catheterization and urethral injury. It is a must to know skill for every graduating medical student to avoid devastating consequences of performing it poorly. The objectives of this study are to evaluate the effectiveness of four step method of skill learning of bladder catheterization in female patients by interns and demonstrate the competency in the proper insertion and removal of an indwelling urinary catheter and also the study aimed to determine the effectiveness of bladder simulator training for medical interns.Methods: A prospective, observational and skill imparting study done using a specially designed model, after ethical committee approval. 30 Interns were divided in to six groups of five each for skill learning. It was done with Kirkpatrik model using specially designed objective structured clinical examination forms and scoring sheets. Sample paired t test was used.Results: 80% of the interns could perform the skill with maximum scores.Conclusions: It is an innovative teaching learning method for incoming interns which will help them to improve knowledge and practice and finally reduce the risk of complications and injury.

1-{1-[2,8-Bis(trifluoro­meth­yl)-4-quin­olyl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone

There are two independent mol­ecules in the asymmetric unit of the title compound, C16H10F6N4O. The triazole ring is not coplanar with the quinoline ring system; the dihedral angle between the two planes being 74.47 (12) and 63.97 (13)° in the two mol­ecules. The crystal structure is characterized by inter­molecular C—H⋯F, C—H⋯N and C—H⋯O hydrogen bonding. Weak intra­molecular C—H⋯F inter­actions are observed. Disorder is observed in two F atoms of one of the trifluoro­methyl groups of one independent mol­ecule [occupancy ratios 0.77 (3):0.23 (3) and 0.77 (4):0.23 (4)] and in all three F atoms of one of the trifluoro­methyl groups of the second independent mol­ecule [occupancy ratios 0.520 (14):0.480 (14), 0.615 (17):0.385 (17) and 0.783 (11):0.217 (11)]. The O atom is also disordered over two positions with occupancies of 0.60 (13) and 0.40 (13) in the first mol­ecule

Comprehensive assessment of lumpy skin disease prevalence across Asia and African countries: A systematic review and meta-analysis

Lumpy Skin Disease (LSD) stands out as one of the economically significant ailments affecting both small-scale farmers and the broader livestock industry. To gauge its prevalence across Asia and Africa, this study employs a rigorous methodology combining systematic review, and meta-analysis, accounting for heterogeneity. Adhering to the guidelines set forth by the cochrane collaboration’s preferred reporting items for systematic reviews and meta-analysis, present initial search sifted through approximately 6,000 articles spanning from 1990 to 2022, using carefully crafted combinations of keywords; Boolean operators, asterisks, and quotation marks. After meticulous assessment for quality bias, employing inclusion and exclusion criteria, 52 publications were included in present study for analysis. The methodology involved in current study utilizing scientometric tools to determine LSD prevalence, with a median sample size of 293 across various studies, predominantly focusing on cattle and buffaloes. Meta-analysis outcomes were dissected based on parameters such as study period, sample size, tests employed, continents, and species, with samples stratified into two to three categories based on medians for heterogeneity assessment. Meta-analysis unveiled a pooled prevalence rate of 14% in Asia and Africa. The subgroup analysis found an 11% prevalence in Asia and Africa constituted 21%. Clinical observation showed a 19% prevalence followed by other tests and PCR with 12 and 13%, respectively. The results underscore the necessity for effective strategies to control and prevent LSD spread, mitigating its economic impact on the livestock industry. This collaborative and comprehensive assessment is crucial in combating the widespread dissemination of LSD and offers valuable insights for policymakers, veterinarians, and stakeholders in the livestock sector

Human protein reference database—2006 update

Human Protein Reference Database (HPRD) () was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data