1 research outputs found
MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
The
Aurora kinases are essential for cell mitosis, and the dysregulation
of Aurora A and B have been linked to the etiology of human cancers.
Investigational agents MLN8054 (<b>8</b>) and alisertib (MLN8237, <b>10</b>) have been identified as high affinity, selective, orally
bioavailable inhibitors of Aurora A that have advanced into human
clinical trials. Alisertib (<b>10</b>) is currently being evaluated
in multiple Phase II and III clinical trials in hematological malignancies
and solid tumors