Biochemical verification of tobacco-use as an inclusion criterion in smoking cessation trials- Lessons from the Cessation of Smoking Trial in the emergency department

INTRODUCTION: Biochemical verification of smoking status prior to recruitment into smoking cessation trials is widely used to confirm smoking status, most commonly using exhaled carbon monoxide (CO). There is variation in the level of CO used as a biochemical inclusion criterion, and thus the possibility for people reporting to be current smokers to be incorrectly excluded from trials. METHODS: As part of the Cessation of Smoking Trial in the Emergency Department, people attending the Emergency Department (ED) who reported being current daily smokers underwent CO testing to confirm eligibility. Elective semi-structured interviews were undertaken with the researchers who recruited participants. As part of the interviews, researchers were asked their views and experiences with CO testing. RESULTS: Of the 1320 participants who reported being current daily smokers and underwent CO testing, 300 (22.7%) blew a CO reading of 7 ppm or less and were excluded from taking part. Possible explanations offered by researchers for participants blowing low CO readings were (1) long wait times in the ED, therefore a long period having elapsed since people had last smoked and (2) patients having reduced smoking for the period before the ED attendance due to ill health. CONCLUSIONS: Biochemical verification has the potential to improve internal validity of smoking cessation for inclusion in trials, but at the cost of reduced generalisability through exclusion of participants who would receive the intervention if it were implemented in practice. We would recommend researchers carefully consider whether it is appropriate and necessary to include biochemical verification as an inclusion criterio

The Value of Self-Ligating Brackets in Orthodontics: About the Damon Protocol

In orthodontics there has been a change in the treatment plan of crowding cases from extraction protocol. This was mainly due to the introduction of self-ligating bracket and temperature activated wires. Even though there are certain exceptions, the self-ligating bracket have evolved in orthodontics because of its advantages such as low friction, shorter treatment duration and increased efficacy. Damon’s self-ligating system has been in existence since 1930 but it has been well developed in the past 30 years with the introduction of newer systems. Damon’s self-ligating brackets have been designed to overcome the drawbacks of conventional bracket system and are often considered as the pinnacle of bracket technology. The main advantage of Damon’s system was low friction and shorter treatment duration. But the efficiency of the appliance is influenced by several factors such as Biomechanics, frequency of dental visits and patient comfort. The chapter will highlight the efficiency of the appliance, the various possible outcomes and its influence on the ease of orthodontic therapy