A comparative study of efficacy of midazolam and triclofos as oral premedication in children undergoing minor surgical procedures

Background: In Paediatric population, premedication is oftenly used to decrease preoperative anxiety, facilitate separation from parents and to get acceptance for face mask induction. Our study was aimed to compare the efficacy of oral midazolamandoral Triclofos as premedicants in children as sedatives, anxiolytics and to promote acceptance of facemask. Patients & Methods: Our study is prospective, randomized, double blind, controlled study involving fifty ASA-1 children between 1 to 10 years of age, undergoing elective surgery. Group A patients was allotted oral Midazolam 0.5mg kg-1 while Group B patients received Triclofos 75mg kg-1 orally as premedication. Assessment of the allowance of premedication, degree of sedation, level of anxiolysis and acceptance of face mask was done by separate scoring methods at intervals of 30 minute (till a maximum of 3 assessments) up to the child was shifted to the operating room. A parental questionnaire was useful to judge the parental satisfaction. Results: In Group A, 21 patients (82%) were awake, but calm and 4 patient (18%) was asleep during the first assessment done 30 minutes after the administration of the drug, while in Group B, only 2 patients (10%) were awake and calm and 23 patients (90%) of the patients were asleep (p value 0.000). In Group I, 13 patients (55%) did not resist the face mask and 12 patients (44%) showed slight resistance while in Group B, 2 patients (11%) showed no resistance to face mask and 13 patients (55%) showed slight resistance. Facemask acceptance was more in Group A (p value of 0.014). Conclusion: Conclusion from our study was that oral Triclofos has better premedication effect as children were sedated, calm and asleep whereas children those received oral midazolam as premedication were awake but calm and quality of face mask acceptance was better

CHARACTERIZATION, RHEOLOGY AND SHEAR INDUCED REACTIONS OF POLY(VINYL ACETATE)

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