, with each row indicating one distinct haplotype and the number of isolates with that haplotype

Only polymorphic positions are included; blue cells indicate identity with the TIGR reference. The figure is divided vertically into thirds: the region upstream of , itself, and the region downstream of . Numerals in the first row indicate the position of the polymorphic nucleotide relative to ('-' refers to positions upstream of , '+' refers to positions downstream of ). For the upstream indel region, a: deletion of bases [-710, -677], b: deletion of bases [-729, -679], c: deletion of bases [-710, -694], d: insertion of 17 bases after nucleotide -675 (act ggg ggg aaa tgc tc), e: deletion of bases [-746, -696]. Within dhfr, the 4 letters within a single column refer to the amino acids at positions 57, 58, 61 and 117. For the indel within the coding region, 1: deletion of codons 98–103, 2: deletion of codons 93–98, 3: insertion of 18 nucleotides between wildtype codons 98 and 99 (agc ggt ggt gac aac aca), 4: insertion of 18 bp between codons 99 and 100 (tgg tga caa cac aag cgg). Within , the numerals 69, 93 and 199 refer to synonymous or non-synonymous changes at those codons. If the nucleotide mutation yielding 58R is not indicated, the change is 174G. The Thai 57L/58R/61M/117T alleles carry A at nucleotide 171, while the Thai 57I/58R/61M/117T alleles carry A at nucleotide 171 and A at nucleotide 169. Countries are abbreviated as follows: Colombia (Col), Indonesia (Indo), Nicaragua (Nic), Panama (Pan), Papua New Guinea (PNG), Sri Lanka (SL), Thailand (Thai), Vanuatu (Van), Vietnam (Viet).<p><b>Copyright information:</b></p><p>Taken from "Multiple origins of resistance-conferring mutations in "</p><p>http://www.malariajournal.com/content/7/1/72</p><p>Malaria Journal 2008;7():72-72.</p><p>Published online 28 Apr 2008</p><p>PMCID:PMC2383903.</p><p></p