13 research outputs found
Algorithm for solutions of nonlinear equations of strongly monotone type and applications to convex minimization and variational inequality problems
Real-life problems are governed by equations which are nonlinear in nature.
Nonlinear equations occur in modeling problems, such as minimizing costs in
industries and minimizing risks in businesses. A technique which does not
involve the assumption of existence of a real constant whose calculation is
unclear is used to obtain a strong convergence result for nonlinear equations
of (p, {\eta})-strongly monotone type, where {\eta} > 0, p > 1. An example is
presented for the nonlinear equations of (p, {\eta})-strongly monotone type. As
a consequence of the main result, the solutions of convex minimization and
variational inequality problems are obtained. This solution has applications in
other fields such as engineering, physics, biology, chemistry, economics, and
game theory.Comment: 11 page
Algorithm for Solutions of Nonlinear Equations of Strongly Monotone Type and Applications to Convex Minimization and Variational Inequality Problems
Experimental Comparison of Video Streaming Platforms and Devices with Objective Quality of Experience Metrics Towards Reliable Multimedia Applications in Education
Study of bio-synthesised transition nano metal oxides dispersed polyester composites as enhanced protectors for mild steel in 0.5Â M H 2
Isolation and Growth Characteristics of Chromium(VI) and Pentachlorophenol Tolerant Bacterial Isolate from Treated Tannery Effluent for its Possible Use in Simultaneous Bioremediation
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SIRT1-NOX4 signaling axis regulates cancer cachexia.
Approximately one third of cancer patients die due to complexities related to cachexia. However, the mechanisms of cachexia and the potential therapeutic interventions remain poorly studied. We observed a significant positive correlation between SIRT1 expression and muscle fiber cross-sectional area in pancreatic cancer patients. Rescuing Sirt1 expression by exogenous expression or pharmacological agents reverted cancer cell-induced myotube wasting in culture conditions and mouse models. RNA-seq and follow-up analyses showed cancer cell-mediated SIRT1 loss induced NF-κB signaling in cachectic muscles that enhanced the expression of FOXO transcription factors and NADPH oxidase 4 (Nox4), a key regulator of reactive oxygen species production. Additionally, we observed a negative correlation between NOX4 expression and skeletal muscle fiber cross-sectional area in pancreatic cancer patients. Knocking out Nox4 in skeletal muscles or pharmacological blockade of Nox4 activity abrogated tumor-induced cachexia in mice. Thus, we conclude that targeting the Sirt1-Nox4 axis in muscles is an effective therapeutic intervention for mitigating pancreatic cancer-induced cachexia