1 research outputs found
Antitumor Effect by Hydroxyapatite Nanospheres: Activation of Mitochondria-Dependent Apoptosis and Negative Regulation of Phosphatidylinositol-3-Kinase/Protein Kinase B Pathway
Hydroxyapatite nanoparticles
(HA NPs) have been acknowledged for
their benign biocompatibility and proliferation inhibition effect
on tumor cells, attracting considerable attention for tumor therapeutics
without late effects. However, unnoticeable tumor cytotoxicity of
HA NPs limited the final clinical therapeutic efficacy. Herein, a
two-phase synthetic approach was developed to synthesize sphere-like
HA NPs by varying the conventional growth habit of HA precipitate.
We present our <i>in vitro</i> and <i>in vivo</i> experimental evidence that spherical HA NPs have surprisingly high
inhibitory activities against tumor cells. We demonstrate further,
based on our experimental data, that the underlying cause for the
death of the tumor cells is related to two concurrent pathways, the
mitochondria-dependent apoptosis pathway and negative regulation of
the phosphatidylinositol-3-kinase/protein kinase B (PIK3/AKT) pathway.
The present study indicated that HA nanospheres can be engineered
as nontoxic specific inhibitors for efficient tumor therapeutics with
nanobiomaterials