Cumulative survival rates free of functional class III to IV due to decompensated heart failure in all PAH-CHD patients with different types of anatomical-pathophysiological classification: 1) Pre-tricuspid shunts (solid line), 2) Post-tricuspid shunts (---), 3) Combined shunts (…), and 4) Complex shunts (^{_ _ _}).

<p>Cumulative survival rates free of functional class III to IV due to decompensated heart failure in all PAH-CHD patients with different types of anatomical-pathophysiological classification: 1) Pre-tricuspid shunts (solid line), 2) Post-tricuspid shunts (---), 3) Combined shunts (…), and 4) Complex shunts (^{_ _ _}).</p

The study cohort based on clinical classifications.

<p>(PAH, pulmonary arterial hypertension; CHD, congenital heart disease).</p

Cumulative survival of all PAH-CHD patients with different types of anatomical-pathophysiological classification: 1) Pre-tricuspid shunts (solid line), 2) Post-tricuspid shunts (---), 3) combined shunts (…), and 4) Complex shunts (^{_ _ _}).

<p>Cumulative survival of all PAH-CHD patients with different types of anatomical-pathophysiological classification: 1) Pre-tricuspid shunts (solid line), 2) Post-tricuspid shunts (---), 3) combined shunts (…), and 4) Complex shunts (^{_ _ _}).</p

Predictors of mortality.

<p>Predictors of mortality.</p

Cumulative survival of all PAH-CHD patients with different clinical classifications: 1) ES (Eisenmenger syndrome) + PAH-small defect + PAH after defect correction (solid line), and 2) PAH with prevalent systemic to pulmonary shunt (dashed line).

<p>Cumulative survival of all PAH-CHD patients with different clinical classifications: 1) ES (Eisenmenger syndrome) + PAH-small defect + PAH after defect correction (solid line), and 2) PAH with prevalent systemic to pulmonary shunt (dashed line).</p

Patient demographics with anatomical-pathophysiological classifications (n = 366).

<p>Patient demographics with anatomical-pathophysiological classifications (n = 366).</p

Predictors of combined mortality with declined functional class to III-IV due to decompensated heart failure.

<p>Predictors of combined mortality with declined functional class to III-IV due to decompensated heart failure.</p

Cumulative survival of all PAH-CHD patients with different clinical classifications: 1) Eisenmenger syndrome (solid line), 2) PAH with prevalent systemic to pulmonary shunt (---), 3) PAH with small defect (^{_ _ _}) and 4) PAH after defect correction (…).

<p>Cumulative survival of all PAH-CHD patients with different clinical classifications: 1) Eisenmenger syndrome (solid line), 2) PAH with prevalent systemic to pulmonary shunt (---), 3) PAH with small defect (^{_ _ _}) and 4) PAH after defect correction (…).</p

Cumulative survival rate free of functional class III to IV, due to decompensated heart failure in all PAH-CHD patients with different clinical classifications: 1) Eisenmenger syndrome (solid line), 2) PAH with prevalent systemic to pulmonary shunt (---), 3) PAH with small defect (^{_ _ _}), and 4) PAH after defect correction (…).

<p>Cumulative survival rate free of functional class III to IV, due to decompensated heart failure in all PAH-CHD patients with different clinical classifications: 1) Eisenmenger syndrome (solid line), 2) PAH with prevalent systemic to pulmonary shunt (---), 3) PAH with small defect (^{_ _ _}), and 4) PAH after defect correction (…).</p

Patient demographics based on clinical classifications (n = 366).

<p>Patient demographics based on clinical classifications (n = 366).</p