Correction to: Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects

Unfortunately, after publication of this article [1], it was noticed that some corrections to Table 2 were not carried out. The corrected Table 2 can be seen below and the original article has also been updated to reflect this

Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects

Abstract Background Solid evidence indicates that intake of marine n-3 fatty acids lowers serum triglycerides and that replacing saturated fatty acids (SFA) with polyunsaturated fatty acids (PUFA) reduces plasma total cholesterol and LDL cholesterol. The molecular mechanisms underlying these health beneficial effects are however not completely elucidated. The aim of this study was therefore to investigate the expression of genes related to lipid metabolism in peripheral blood mononuclear cells (PBMC) depending on the plasma levels of n-6 and n-3 fatty acids and the SFA to PUFA ratio. Methods Fifty-four healthy subjects were grouped into tertiles (n = 18) based on plasma levels of n-6 and n-3 fatty acids and the SFA to PUFA ratio. The PBMC gene expression levels among subjects in the highest versus the lowest tertiles were compared. In total, 285 genes related to cholesterol and triglyceride metabolism were selected for this explorative study. Results Among the 285 selected genes, 161 were defined as expressed in the PBMCs. The plasma SFA to PUFA ratio was associated with the highest number of significantly different expressed genes (25 gene transcripts), followed by plasma n-6 fatty acid level (15 gene transcripts) and plasma n-3 fatty acid level (8 gene transcripts). In particular, genes involved in cholesterol homeostasis were significantly different expressed among subjects with high compared to low plasma SFA to PUFA ratio. Conclusion Genes involved in lipid metabolism were differentially expressed in PBMCs depending on the plasma fatty acid levels. This finding may increase our understanding of how fatty acids influence lipid metabolism at a molecular level in humans

Differences in peripheral blood mononuclear cell gene expression and triglyceride composition in lipoprotein subclasses in plasma triglyceride responders and non-responders to omega-3 supplementation

Background Intake of the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduces fasting triglyceride (TG) levels and may thereby lower cardiovascular disease risk. However, there are large inter-individual differences in the TG-lowering effect of omega-3 supplementation. Genotype differences partly explain this variation, but gene-environment interactions leading to gene expression differences may also be important. In this study, we aimed to investigate baseline differences and differences in the change in peripheral blood mononuclear cell (PBMC) gene expression and lipoprotein subclass TG levels between TG responders and non-responders to omega-3 fatty acid supplementation. Methods In a previous randomized controlled trial, healthy normotriglyceridemic subjects (n = 35, 71% women) received 1.6 g EPA + DHA/day for 7 weeks. In this exploratory sub-study, we defined TG responders as subjects having a TG reduction beyond the 20% day-to-day variation and non-responders as having a TG change between − 20% and + 20% after omega-3 supplementation. PBMC gene expression was measured using microarray, and lipoprotein subclasses were measured using nuclear magnetic resonance spectroscopy. Results Eight subjects were defined as responders with a median TG reduction of 37%, and 16 subjects were defined as non-responders with a median TG change of 0%. At baseline, responders had higher TG levels in two of four high-density lipoprotein (HDL) subclasses and 909 gene transcripts (p ≤ 0.05) were differentially expressed compared to non-responders. During the intervention, the plasma TG reduction among responders was reflected in TG reductions in four of six different very low-density lipoprotein subclasses and three of four different HDL subclasses. Compared to non-responders, the expression of 454 transcripts was differentially altered in responders (p ≤ 0.05). Pathway analyses revealed that responders had altered signaling pathways related to development and immune function. In addition, two of the top 10 enriched pathways in responders compared to non-responders were related to lysophosphatidic acid signaling. Conclusion TG responders and non-responders to omega-3 supplementation have different lipoprotein subclass and PBMC gene expression profiles at baseline and different lipoprotein subclass and PBMC gene expression responses to omega-3 supplementation. These gene expression differences may partially explain the variability in TG response observed after omega-3 supplementation. Graphical abstract Based on free images from Servier Medical Art (Creative Commons Attribution License) and image from www.colourbox.com

γ-Ray Strength Functions and GDR Cross Sections in the IAEA Photonuclear Data Project

We present the latest development of measuring (γ, n) cross sections and giant dipole resonance (GDR) cross sections in the IAEA photonuclear data project. Photoneutron cross sections were measured for 21 isotopes below 2n threshold to construct the γ-ray strength function (γSF) with the γSF method; (γ, n) cross sections are used as experimental constraints on the model E1 and M1 γSFs from the Hartree–Fock–Bogolyubov plus quasi-particle random phase approximation based on the Gogny D1M interaction supplemented with the M1 upbend. GDR cross sections were measured for 11 nuclei from9Be to209Bi by direct neutron-multiplicity sorting with a flat-efficiency neutron detector toward a goal of resolving the long-standing discrepancy between the Livermore and Saclay data. We present γSFs for the Ni isotopic chain and GDR cross sections for159Tb as well as those updated for209Bi.SCOPUS: cp.pinfo:eu-repo/semantics/publishe

Strong enhancement of level densities in the crossover from spherical to deformed neodymium isotopes

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Statistical properties of the well deformed Sm 153,155 nuclei and the scissors resonance

The nuclear level densities (NLDs) and the γ-ray strength functions (γSFs) of Sm153,155 have been extracted from (d,pγ) coincidences using the Oslo method. The experimental NLD of Sm153 is higher than the NLD of Sm155, in accordance with microscopic calculations. The γSFs of Sm153,155 are in fair agreement with QRPA calculations based on the D1M Gogny interaction. An enhancement is observed in the γSF for both Sm153,155 nuclei around 3 MeV in excitation energy and is attributed to the M1 scissors resonance (SR). Their integrated strengths were found to be in the range 1.3-2.1 and 4.4-6.4 μN2 for Sm153 and Sm155, respectively. The strength of the SR for Sm155 is comparable to those for deformed even-even Sm isotopes from nuclear resonance fluorescence measurements, while that of Sm153 is lower than expected.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

New experimental constraint on the 185W(n,γ)186W cross section

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