Metaplastic Carcinoma of the Left Breast with Extensive Chondroid Differentiation

Metaplastic breast carcinoma is very rare neoplasm which contains mixture of carcinomatous (epithelial) and sarcomatous (mesenchymal) elements in variable proportion. Metaplastic carcinoma with chondroid differentiation is even rarer. We report a case of metaplastic carcinoma with extensive chondroid differentiation as there is paucity of information regarding pathological features and clinical outcomes for these rare tumors. Tumor had characteristic definite areas of classic infiltrating duct carcinoma with abundant chondromyxoid matrix, focal areas of chondrosarcoma and cartilagenous metaplasia. Tumour cells were immunoreactive for S-100, ER, and PR. When pathologist encounter breast tumor with chondroid differentiation, careful gross sampling, histopathology and immunoreactivity for mesenchymal and epithelial component are most useful to differentiate metaplastic carcinoma from malignant phylloides tumors and malignant adenomyoepithelioma

Uterine Lipoleiomyoma: a rare variant of benign uterine neoplasm

The lipomatous tumors are very rare benign neoplasms of the uterus. Lipoleiomyoma is a benign tumor which is variant of leiomyoma. It has similar clinical course and presentation like uterine leiomyoma and is typically found in postmenopausal women. Authors report a case of 45 years female presented with a complaint of increased frequency of menstrual cycles and generalized weakness since 5- 6 months. On ultrasonography abdomen - pelvis a single large lobulated hyperechoic mass was noted in the fundal myometrium measuring 5 x 4.6 cm. The finding was suggestive of fibroid uterus. On histopathological examination showed variable proportions of lobules of mature adipocytes and interlacing bundles of benign smooth muscle cells which was diagnostic of lipoleiomyoma. Authors are presenting this case for its rarity, clinical presentation, imaging and histopathological finding with differential diagnosis

Study of ectopic pregnancy in a tertiary care centre

Background: Ectopic pregnancy is a life threatening emergency leading to maternal death. Incidence of ectopic pregnancies has been increasing in last two to three decades with reduction in mortality. The presenting symptoms include abdominal pain, amenorrhoea and/or irregular vaginal bleeding. The present study was undertaken to study the clinical features of ectopic pregnancies in a tertiary care hospital.Methods: The present study on ectopic pregnancies was carried out in Department of Pathology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India from January 2010 to June 2014. All the cases of ectopic pregnancy managed surgically were included in the study.Results: Total 102 cases of ectopic pregnancy were studied. Proportion of ectopic pregnancy in the present study is 1 in 205 deliveries. Majority of the cases (37) (36.27%) were noted between 21 to 25 years of age group followed by the age group 26 to 30 years. Ectopic pregnancy was most commonly noted in nulliparous women (44/102) (43.14%). Majority of the cases (50/102) (49.02%) had no risk factors. Abortion was the most common risk factor identified, alone as well as in conjunction with other factors. Ampulla was the most common site for ectopic pregnancy. 55% of the cases were on the right side where as 45% on the left side. We had 2 cases of heterotropic pregnancy with tubal ectopic in both the cases. The typical triad of amenorrhoea, pain in abdomen and bleeding was observed in 21.57% cases.Conclusions: The incidence of ectopic pregnancies is on rise as evident in this study. In order to reduce the morbidity and mortality due to ectopic pregnancies, there is need for early diagnosis especially in high risk cases

Unusual Presentation of Eosinophilic Enteritis as Multiple Strictures of Small Intestine

Eosinophilic enteritis is a rare disease of unknown etiology. It is characterized by eosinophilic infiltration of the bowel wall to a variable depth and symptoms associated with gastrointestinal tract depending upon the predominant layer involved. Diagnosis of eosinophilic enteritis requires a high index of suspicion and exclusion of various disorders that are associated with peripheral eosinophilia. We report a case of unusual presentation of eosinophilic enteritis clinically presenting as intestinal obstruction due to multiple strictures of the small bowel in an adult male

Epilepsy – Clinico-etiological Profile at Tertiary Care Centre

Aims and Objectives: To evaluate clinical, etiological and electroencephalogram profile in seizure patients. Materials and Methods: The cases having episodes of seizure were studied. This was descriptive, analytical, observational type of study, done at tertiary care hospital. Duration of study period was 3 years. Detailed clinical baseline information regarding age, onset age of seizure, type, duration, associated autonomic changes etc. were studied. Relevant birth, family and past history, medication etc. were noted. Routine investigations, radiological findings and electroencephalogram changes were noted. Additional investigations were done wherever required. Results: Total 200 cases were studied over a three year period. The age range for seizures was from 2 month to 75 years, with maximum number of cases were in first and second decade. The male: female ratio was 2.7:1. The main etiological factor was idiopathic in 114 cases(76.51%) followed by neurodegenerative disorders ( 7.38% ) ,developmental disorders (5.3%), head trauma (2.6%), organic lesions (2.0%) and other with infections, cerebro-vascular diseases, alcoholism, psychological, metabolic etc. Conclusion: Among 200 cases of seizures, the epileptiform activity was observed in 149 patients. During the study period, a total of 200 cases were studied. The epileptiform activity was observed in 149 patients. The age range for seizures was from 2 months to 75 year. The male: female ratio was 2.7:1. The common type of seizures observed were of focal(54.35%) in which complex partial 60 cases and simple partial 21 cases, while generalized seizures were in 61 cases (45.65%) in which tonic-clonic type were common. The common etiological factor in our study who showed epileptiform activity on EEG was idiopathic 76.51%. In this rural area there is substantial burden of epilepsy ,it requires health care resources, proper counseling, diagnostic modalities and patient care

Primary Renal Leiomyosarcoma: Case Report and Review of the Literature

Renal leiomyosarcoma is an extremely rare malignant tumor. On clinical presentation and radio imaging it is challenging to make an accurate preoperative diagnosis. In our case, a 59-year-old female presented with history of left-sided flank pain, intermittent hematuria and weight loss of 6 months duration. She was known case of hypertension and diabetes mellitus of 20 years and on regular treatment. On the abdomino-pelvis sonography showed an exophytic cortical mass lesion measuring 4.0 x 3.8 cm lesion. Magnetic resonance imaging abdomen and pelvis (plain) shows a well defined non encapsulated exophytic predominantly solid mass lesion measuring 4.3 x 4 x 4.5 cm is noted in the anterior cortex of left kidney at interpolar region. There was no evidence of any regionalor distant metastesis. Patient underwent left radical nephrectomy. On histopathology reported as renal leiomyosarcoma. Immuhistochemistry showed smooth muscle actin diffusely and desmin focally positive. We present this review of rare case of primary renal leiomyosarcoma for its clinical presentation, radiographic findings, and pathologic features

Primary Signet-Ring Carcinoma (Linitus Plastica) of the Colorectum presenting as Subacute Intestinal Obstruction

Primary Signet-ring cell carcinoma (Linitus Plastica) of the colon and rectum is a rare form of adenocarcinoma of the large intestine and has been reported to have an extremely poor prognosis. We report a case of Primary Signet-ring cell carcinoma of the colorectum in a thirty one year old man presented in Surgical OPD of our hospital with chief complaints of persistent pain in abdomen and vomiting since two days. Since the prognosis of primary signet ring cell carcinoma (SRCC) is extremely poor (in view of more malignant behavior than ordinary colorectal carcinoma), early diagnosis and aggressive treatment strategy are necessary

Idiopathic eosinophilic cholecystitis with Cholelithiasis- a rare histopathological variant

Eosinophilic cholecystitis is a rare form of cholecystitis presented with classical symptoms of cholecystitis and diagnosed on histopathology in presence of more than 90% eosinophilic infiltrate with in wall of gallbladder . We report case in a 55 year old male presented to surgical department having complaints of upper right abdominal pain, tenderness, associated with vomiting since 8 days. On ultrasonography abdomen-pelvis show distended gallbladder with calculus of size 1.7 cm at fundic region .The wall of gallbladder thickened and edematous .Mild heterogenous intraluminal debris was noted. Open cholecystectomy was performed . Gallbladder specimen on histopathologically diagnosed as eosinophilic cholecystitis with cholelithiasis. We are presenting this case for its rarity , its clinical and histopathological findings

Unusual presentation of eosinophilic enteritis as multiple strictures of small intestine

Eosinophilic enteritis is a rare disease of unknown etiology. It is characterized by eosinophilic infiltration of the bowel wall to a variable depth and symptoms associated with gastrointestinal tract depending upon the predominant layer involved. Diagnosis of eosinophilic enteritis requires a high index of suspicion and exclusion of various disorders that are associated with peripheral eosinophilia. We report a case of unusual presentation of eosinophilic enteritis clinically presenting as intestinal obstruction due to multiple strictures of the small bowel in an adult male

Scholars Journal of Medical Case Reports ISSN 2347-9507 (Print) Tubular Carcinoma of Breast: A Specific Breast Malignancy

Abstract: Tubular carcinoma of the breast is an uncommon, histologic subtype which has distinct morphological features and important for diagnosing and its further management. In our case patient presented at advance age having small lump in right breast. On Fine Needle Aspiration Cytology (FNAC) examination showed features of epithelial proliferative lesion with atypia. On histopathology diagnosed as low grade ductal carcinoma -tubular carcinoma with invasive foci. We are presenting this case for its uncommon subtype, late age of presentation and its histopathological findings