Neonatal diabetes mellitus due to a rare mutation in KCNJ11 gene

Neonatal diabetes is a heterogeneous group of rare monogenic disorders with an incidence of about 1 in 100,000 live births presenting with in the first 6 months of life with polyuria, dehydration, and ketoacidosis. We, hereby, present a case of neonatal diabetes mellitus due to a very rare mutation (reported 1st time from Indian population) affecting the KCNJ11 gene encoding for KIR6.2 subunit of KATP channels resulting in inhibition of insulin release and hyperglycemia, leading to permanent neonatal diabetes for which sulfonylurea is the preferred treatment. Instead of insulin injection as endogenous insulin synthesis is not affected unlike other causes of permanent neonatal diabetes mellitus affecting insulin synthesis for which insulin is the only treatment

Feed Forward Artificial Neural Network: Tool for Early Detection of Ovarian Cancer

Pathological changes in an organ or tissue may be reflected in proteomic patterns in serum. The early detection of cancer is crucial for successful treatment. Some cancers affect the concentration of certain molecules in the blood, which allows early diagnosis by analyzing the blood mass spectrum. It is possible that exclusive serum proteomic patterns could be used to differentiate cancer samples from non-cancer ones. Several techniques have been developed for the analysis of mass-spectrum curve, and use them for the detection of prostate, ovarian, breast, bladder, pancreatic, kidney, liver, and colon cancers. In present study, we applied data mining to the diagnosis of ovarian cancer and identified the most informative points of the mass-spectrum curve, then used student t-test and neural networks to determine the differences between the curves of cancer patients and healthy people. Two serum SELDI MS data sets were used in this research to identify serum proteomic patterns that distinguish the serum of ovarian cancer cases from non-cancer controls. Statistical testing and genetic algorithm-based methods are used for feature selection respectively. The results showed that (1) data mining techniques can be successfully applied to ovarian cancer detection with a reasonably high performance; (2) the discriminatory features (proteomic patterns) can be very different from one selection method to another

IN VITRO ABSORPTION STUDY OF CARBAMAZEPINE SOLID DISPERSION USING EVERTED GUT SAC METHOD

The oral Bioavailability of BCS (Bio Pharmaceutical Classification System) class II drug with poor solubility and reasonable permeability is limited by drug dissolution. In order to improve the aqueous solubility of the drug and dissolution of thedrug, the solid dispersion was prepared and evaluated for its absorption in intestine using modified everted gut sac method. The solid dispersion of carbamezepine (CBZ) was prepared using polaxomer and guargum by kneading method. The CBZ and CBZSD (Solid Disposisi) shows 2.329% and 3.948% drug absorption, respectively. The data show that solid dispersion increase the absorption of the CBZ in CBZ-SD is more than 70% in comparison to pure CBZ. The increase in CBZ solubility of the SD could be attributed to several factors such as improved wettability, local solubilization, drug particle size reduction and crystalline or, interstitial solid solution reduction. Key words: Everted gut sac method, solid dispersion, absorption, solubilit

Concept of Symmetrical Component as a Technique for analysis of fault and Improvement of Over current Protection Scheme

Electrical energy is one of the fundamental resources of the modern industrial society. Electrical power is available to the user instantly, at the correct voltage and frequency, at exactly the amount needed. The power system maintains its steady state mainly because of the correct and quick remedial action taken by the protective relaying equipment. The response of the protection system must be automatic, quick, and should cause a minimum amount of disruption to the power system. Concept of Symmetrical component for an enhancing protection scheme shows an outstanding feature. The method of symmetrical components provides a practical technology for understanding and analyzing power system operation during unbalanced conditions. Such as those caused by faults between phases and/or ground, open phases, unbalance impedances, and so on. Also, many protective relays operate from the symmetrical component quantities. Thus a good understanding of this subject is of great value and very important tool in protection. In this paper how the concept of symmetrical components helps for improvement of different protection schemes

Safe obstetric anesthesia practice-COVID-19

COVID-19 or Corona virus disease 2019 was declared a pandemic by the WHO on 11th March 2020. Cesarean delivery is a commonly performed major surgery around the world. Important considerations while performing a cesarean section on a confirmed or suspected case of COVID19 are safety of the woman and the fetus; and prevention of transmission of SARS-CoV2 infection to the fetus as well as the healthcare providers. Woman and her birthing partner should be screened for the symptoms of COVID-19 before scheduled admission. Cesarean section in a woman suffering from COVID-19 should be managed by a multidisciplinary team consisting of anesthetists, obstetricians, labor and delivery nurses, neonatologist, critical care experts and infectious disease specialists, all members working in tandem with each other. General changes in workflow, reorganization of obstetric anesthesia services and proper use of personal protective equipment (PPE) are required for safe delivery of obstetric anesthesia during the COVID pandemic. Regional anesthesia is the preferred method of anesthesia for cesarean delivery. Using regional anesthesia reduces the need of aerosol generating procedures and avoids the use of mechanical ventilation. It also decreases the possibility of exacerbating the respiratory complications due to intubation. General anesthesia is recommended when a COVID-19 parturient presents with desaturation (oxygen saturation≤ 93%) for emergency cesarean delivery. Use of mechanical barriers around patient’s head during intubation and extubation might reduce exposure. The patient should be allowed to remain in the operating room itself till sufficiently recovered to be shifted directly to the isolation room

Clinical profile of neurological gait ataxia: a hospital based study

Background: Gait disorders are major causes of functional impairment and morbidity especially in the elderly. Most gait disorders in older person are multifactorial, including neurological and non -neurological components. The aim of the study was to determine different neurological causes of gait disorders in elderly as well as in young adults.Methods: A total of 155 patients with gait ataxia were included and studied for demographic profile, clinical features, mode of presentation and aetiology of neurological gait ataxia.Results: Of the 155 patients enrolled in the study for gait disability, the most common cause of gait disability was cerebrovascular accidents 48 (31%) followed by lower motor neuron (LMN) paraparesis20 (12.9%), compressive myelopathy 17 (11%) and infectious causes were reported in 13 (8.4%) patients. Other causes were non-compressive myelopathy 8 (5.2%), Parkinsonism 8 (5.2%), degenerative diseases 6 (3.9%), diabetic amyotrophy 5 (3.2%), sensory neuropathy, hydrocephalus, myopathy and space occupying lesions in 4 (2.6%) patients each.Conclusions: The two most common causes of gait instability in Sub-Himalayan region are cerebrovascular accidents and LMN paraparesis. The LMN parapersis is associated with significant falls

Synthesis, Characterization, and Antibacterial Studies of Mixed Ligand Dioxouranium Complexes with 8-Hydroxyquinoline and Some Amino Acids

Mixed ligand complexes of dioxouranium (VI) of the type [UO2(Q)(L)·2H2O] have been synthesized using 8-hydroxyquinoline (HQ) as a primary ligand and amino acids (HL) such as L-threonine, L-tryptophan, and L-isoleucine as secondary ligands. The metal complexes have been characterized by elemental analysis, electrical conductance, magnetic susceptibility measurements, and spectral and thermal studies. The electrical conductance studies of the complexes indicate their nonelectrolytic nature. Magnetic susceptibility measurements revealed diamagnetic nature of the complexes. Electronic absorption spectra of the complexes show intraligand and charge transfer transitions, respectively. Bonding of the metal ion through N- and O-donor atoms of the ligands is revealed by IR studies, and the chemical environment of the protons is confirmed by NMR studies. The thermal analysis data of the complexes indicate the presence of coordinated water molecules. The agar cup and tube dilution methods have been used to study the antibacterial activity of the complexes against the pathogenic bacteria S. aureus, C. diphtheriae, S. typhi, and E. coli

Bumber landings of koth, Otolithoides biauritus by bottom set gill net at Satpati

Bumber catch of Koth, Otolithoides biauritus was reported on 19th December 2002 at Satpati. Koth was caught in 18-20 meter depths at a distance of 15-18 km north west off Satpati. The heavy concenteration indicates the potential fishing ground of koth in this region

An Efficient Lightweight Provably Secure Authentication Protocol for Patient Monitoring Using Wireless Medical Sensor Networks

The refurbishing of conventional medical network with the wireless medical sensor network has not only amplified the efficiency of the network but concurrently posed different security threats. Previously, Servati and Safkhani had suggested an Internet of Things (IoT) based authentication scheme for the healthcare environment promulgating a secure protocol in resistance to several attacks. However, the analysis demonstrates that the protocol could not withstand user, server, and gateway node impersonation attacks. Further, the protocol fails to resist offline password guessing, ephemeral secret leakage, and gateway-by-passing attacks. To address the security weaknesses, we furnish a lightweight three-factor authentication framework employing the fuzzy extractor technique to safeguard the user’s biometric information. The Burrows-Abadi-Needham (BAN) logic, Real-or-Random (ROR) model, and Scyther simulation tool have been imposed as formal approaches for establishing the validity of the proposed work. The heuristic analysis stipulates that the proposed work is impenetrable to possible threats and offers several security peculiarities like forward secrecy and three-factor security. A thorough analysis of the preexisting works with the proposed ones corroborates the intensified security and efficiency with the reduced computational, communication, and security overheads