Developing textile entrepreneurial inclination model by integrating experts mining and ISM-MICMAC

The Indian textile industry is lacking in an entrepreneurial inclination of a skilled young generation; because of this, the industry is facing a challenge to achieve sustainable development and growth. To overcome this problem, the goal of this work is to build an entrepreneurial inclination model in the context of the textile industry. For achieving this goal, a combined approach of an extensive literature review and experts mining has been used to establish the entrepreneurial inclination factors in phased of the study. In the second phase, an Interpretive Structural Modelling (ISM) with Matrice d'Impacts Croisés Multiplication Appliqués à un Classement (MICMAC) has been applied to build a structural model and to find the driving force factors and dependence power. The results show that effective entrepreneurship courses, institutional policy, training and internship, institutional corporation and the involvement of institutional heads play a very significant role in encouraging youth towards entrepreneurship. The outcomes of the study can help both the government and academic institutes to draw up effective policy and develop an entrepreneurial culture which can help to create more entrepreneurs in the textile field.N

Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach

In the current study a quantitative structure activity relationship approach using sequential multiple linear regression analysis was applied to a series of 2-alkyl- 4-(biphenylylmethoxy)quinolines as angiotensin II (Ang II) receptor antagonists by using Chem 3D and Dragon Software. The studies, carried out on 33 analogs, give statistically significant correlations of selective Ang II antagonistic activity with physical properties concerning size, symmetry, shape and distribution of molecule atoms. Among several 2D quantitative structure activity relationship models, one model gave good statistical significance (r > 0.81, Ftest = 10.47, S < 0.30, chance correlation < 0.01). 3D QSAR studies show that Hennery’s law constant, Dipole and VDWE play a significant role in Ang II antagonistic activity. These QSAR studies help us in the design and prediction of novel substituted benzimidazole Ang II receptor antagonists

An Improved 2-Dimensional Gel Electrophoresis Method for Resolving Human Erythrocyte Membrane Proteins

The 2-dimensional gel electrophoresis (2-DE) technique is widely used for the analysis of complex protein mixtures extracted from biological samples. It is one of the most commonly used analytical techniques in proteomics to study qualitative and quantitative protein changes between different states of a cell or an organism (eg, healthy and diseased), conditionally expressed proteins, posttranslational modifications, and so on. The 2-DE technique is used for its unparalleled ability to separate thousands of proteins simultaneously. The resolution of the proteins by 2-DE largely depends on the quality of sample prepared during protein extraction which increases results in terms of reproducibility and minimizes protein modifications that may result in artifactual spots on 2-DE gels. The buffer used for the extraction and solubilization of proteins influences the quality and reproducibility of the resolution of proteins on 2-DE gel. The purification by cleanup kit is another powerful process to prevent horizontal streaking which occurs during isoelectric focusing due to the presence of contaminants such as salts, lipids, nucleic acids, and detergents. Erythrocyte membrane proteins serve as prototypes for multifunctional proteins in various erythroid and nonerythroid cells. In this study, we therefore optimized the selected major conditions of 2-DE for resolving various proteins of human erythrocyte membrane. The modification included the optimization of conditions for sample preparation, cleanup of protein sample, isoelectric focusing, equilibration, and storage of immobilized pH gradient strips, which were further carefully examined to achieve optimum conditions for improving the quality of protein spots on 2-DE gels. The present improved 2-DE analysis method enabled better detection of protein spots with higher quality and reproducibility. Therefore, the conditions established in this study may be used for the 2-DE analysis of erythrocyte membrane proteins for different diseases, which may help to identify the proteins that may serve as markers for diagnostics as well as targets for development of new therapeutic potential

Estimation of active surface deformation using PSInSAR technique of the Central Himalayan region

AbstractThe Kumaun Himalaya is considered as the most active part of the Central Seismic gap in the Indian Sub-continent. In this paper, we presented active surface deformation rates of the Kumaun region from February 2017 to February 2021 using the Persistent Scatterer Interferometric Synthetic Aperture Radar (PSI) technique. The cumulative displacement that occurred during the span of 4 years is ±55 mm, whereas the Line of Sight (LOS) deformation velocity rate ranges is ±7 mm/yr. Apart from PSI, we also estimated the b-value of the Kumaun region from 1803 to 2021 (399 events) and its value is 0.54 ± 0.03. A distinct NE-SW trend of b-value is observed where earthquakes with M > 6 occurred towards NE of this trend. The PSI-derived deformation reveals that the central part of the Inner Lesser Himalaya along with the Main Central Thrust (MCT) zone is dominated by uplift. The zone between the Munsiari Thrust (MT) and MCT in the central region shows the maximum uplift ranging 5–7 mm/yr which exactly lies above the mid-crustal ramp of the Main Himalayan Thrust (MHT). Our results are well corroborated with available observations of geodetic strain and peak ground acceleration values. However, the deformation patterns and high-velocity rates in the central part of the study area between MT and MCT indicate the accumulation of high stress

Estimation of active surface deformation using PSInSAR technique of the Central Himalayan region

The Kumaun Himalaya is considered as the most active part of the Central Seismic gap in the Indian Sub-continent. In this paper, we presented active surface deformation rates of the Kumaun region from February 2017 to February 2021 using the Persistent Scatterer Interferometric Synthetic Aperture Radar (PSI) technique. The cumulative displacement that occurred during the span of 4 years is ±55 mm, whereas the Line of Sight (LOS) deformation velocity rate ranges is ±7 mm/yr. Apart from PSI, we also estimated the b-value of the Kumaun region from 1803 to 2021 (399 events) and its value is 0.54 ± 0.03. A distinct NE-SW trend of b-value is observed where earthquakes with M > 6 occurred towards NE of this trend. The PSI-derived deformation reveals that the central part of the Inner Lesser Himalaya along with the Main Central Thrust (MCT) zone is dominated by uplift. The zone between the Munsiari Thrust (MT) and MCT in the central region shows the maximum uplift ranging 5–7 mm/yr which exactly lies above the mid-crustal ramp of the Main Himalayan Thrust (MHT). Our results are well corroborated with available observations of geodetic strain and peak ground acceleration values. However, the deformation patterns and high-velocity rates in the central part of the study area between MT and MCT indicate the accumulation of high stress.</p