Z-Axis Optomechanical Accelerometer

We demonstrate a z-axis accelerometer which uses waveguided light to sense proof mass displacement. The accelerometer consists of two stacked rings (one fixed and one suspended above it) forming an optical ring resonator. As the upper ring moves due to z-axis acceleration, the effective refractive index changes, changing the optical path length and therefore the resonant frequency of the optical mode. The optical transmission changes with acceleration when the laser is biased on the side of the optical resonance. This silicon nitride "Cavity-enhanced OptoMechanical Accelerometer" (COMA) has a sensitivity of 22 percent-per-g optical modulation for our highest optical quality factor (Q_o) devicesComment: Published in Proceedings of the 25th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2012), Paris, France, January 29 - Feb 2, 2012, pp. 615-61

Antimicrobial Peptides for Gram-Negative Sepsis: A Case for the Polymyxins

This is the publisher's version, also available electronically from "http://journal.frontiersin.org".No abstract available

Antimicrobial peptides for gram-negative sepsis: a case for the polymyxins

This is the publisher's version, also available electronically from "http://journal.frontiersin.org".No abstract available

The role of polar and facial amphipathic character in determining lipopolysaccharide-binding properties in synthetic cationic peptides

Two series of peptides, designated K and NK were synthesized and tested for lipid A binding and neutralizing properties. K2, which has an 11-residue amphiphilic core, and a branched N-terminus bearing two branched lysinyl residues does not bind lipid A, while NK2, also with an 11-residue amphiphilic core comprised entirely of non-ionizable residues, and a similarly branched, cationic N-terminus, binds lipid A very weakly. Both peptides do not inhibit lipopolysaccharide (LPS) activity in the Limulus assay, nor do they inhibit LPS-induced TNF-α and NO production in J774 cells. These results are entirely unlike a homologous peptide with an exclusively hydrophobic core whose LPS-binding and neutralizing properties are very similar to that of polymyxin B [David SA, Awasthi SK, Wiese A et al. Characterization of the interactions of a polycationic, amphiphilic, terminally branched oligopeptide with lipid A and lipopolysaccharide from the deep rough mutant of Salmonella minnesota . J Endotoxin Res 1996; 3: 369-379]. These data suggest that a clear segregation of charged and apolar domains is crucial in molecules designed for purposes of LPS sequestration and that head-tail (polar) orientation of the cationic/hydrophobic regions is preferable to molecules with mixed or facial cationic/amphipathic character

Kinematical Analogy for Marginal Dyon Decay

We describe a kinematical analogy for the marginal decay of 1/4-BPS dyons in 4-dimensional N=4 string compactifications. In this analogy, the electric and magnetic charges play the role of spatial momenta, the BPS mass plays the role of energy, and 1/2-BPS dyons correspond to massless particles. Using SO(12,1) "Lorentz" invariance and standard kinematical formulae in particle physics, we provide simple derivations of the curves of marginal stability. We also show how these curves map into the momentum ellipsoid, and propose some applications of this analogy.Comment: 10 pages, minor revision

Total Synthesis and Structure–Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine)

By utilizing an l-serine-derived bicyclic lactone as an advanced chiral building block, a short synthetic route to the cytotoxic marine natural product jaspine B has been developed. Targeting structure–activity relationship investigations, the synthetic route has also been utilized for the synthesis and cytotoxicity evaluation of strategically modified jaspine B analogues. In addition, a previously reported synthesis of the title natural product from our research has been reinvestigated to clarify the sterochemical assignment

Lipopolyamines: Novel Antiendotoxin Compounds That Reduce Mortality in Experimental Sepsis Caused by Gram-Negative Bacteria

The interactions of lipopolyamines, a class of structurally unique compounds currently being used as transfection (lipofection) agents, with lipopolysaccharide (LPS) have been characterized. Our studies have demonstrated that 1,3-di-oleoyloxy-2-(6-carboxyspermyl)-propylamide), available commercially as DOSPER, binds to purified LPS with an affinity of about 1/10 that of polymyxin B. This essentially nontoxic compound inhibits, in a dose-dependent manner, LPS-induced activation of the Limulus clotting cascade and the production of tumor necrosis factor alpha (TNF-α) interleukin-6 (IL-6), and nitric oxide from LPS-stimulated J774.A1 cells, a murine macrophage-like cell line. Cytokine inhibition is paralleled by decreased steady-state levels of TNF-α and IL-6 mRNA and inhibits the nuclear translocation of nuclear factor kappa B. These findings suggest that the lipopolyamine compound sequesters LPS, thereby blocking downstream cellular activation events that lead to the production of proinflammatory mediators. Administration of DOSPER to d-galactosamine-sensitized mice challenged either with LPS or with Escherichia coliorganisms provided significant protection against lethality both with and without antibiotic chemotherapy. Partial protection is evident in LPS-challenged mice treated with DOSPER as late as 2 to 4 h following the endotoxin challenge. A greater degree of protection is observed in E. coli-challenged animals receiving ceftazidime than in those receiving imipenem, which is probably attributable to the higher levels of LPS released in vivo by the former antibiotic. Potent antiendotoxic activity, low toxicity, and ease of synthesis render the lipopolyamines candidate endotoxin-sequestering agents of potential significant therapeutic value.This work was supported in part by grants PO1CA54474 from the National Cancer Institute, R37AI23447 from the National Institute of Allergy and Infectious Diseases, and an unrestricted medical grant from Merck & Co., West Point, Pa. S. A. David is a recipient of a Kansas Health Foundation fellowship. T. Suzuki, Q. Xue, and E. Zuvanich are gratefully acknowledged for their help. We thank Promega Inc. for a generous gift of DOGS

The impact of freight transport capacity limitations on supply chain dynamics

We investigate how capacity limitations in the transportation system affect the dynamic behaviour of supply chains. We are interested in the more recently defined, 'backlash' effect. Using a system dynamics simulation approach, we replicate the well-known Beer Game supply chain for different transport capacity management scenarios. The results indicate that transport capacity limitations negatively impact on inventory and backlog costs, although there is a positive impact on the 'backlash' effect. We show that it is possible for both backlog and inventory to simultaneous occur, a situation which does not arise with the uncapacitated scenario. A vertical collaborative approach to transport provision is able to overcome such a trade-off. © 2013 Taylor & Francis