Commonly activated regions in FM patients and healthy control.

<p>Yellow clusters indicate common regions activated by painful stimuli in FM patients and healthy controls. Common regions include bilateral cerebellum, contralateral supramarginal gyrus, IFG and MFG.</p

Statistical comparisons of clinical scores.

<p>(Mean and SD.) (A) FM patients and healthy controls (B) pre-treatment group and post-treatment group. Fibromyalgia Impact Questionnaire (FIQ), Brief Fatigue Inventory (BFI), Beck Depression Inventory (BDI), Widespread Pain Index (WPI), Symptom Severity Scale score (SSS), and State-Trait Anxiety Inventory (STAI). * <i>p</i> < 0.05, ** <i>p</i> < 0.01.</p

Pain-stimulation paradigm of the fMRI scan.

<p>Pain-stimulation paradigm of the fMRI scan.</p

Comparison between responders and non-responders according to medication therapy.

<p>Regions including bilateral fusiform, ipsilateral IPL and contralateral STG were more activated in responders.</p

Comparison between pre-treatment and post-treatment.

<p>Coronal view of functional magnetic resonance images showing activation regions with significantly increased BOLD signals at pre- <i>versus</i> post-treatment in the responder subgroup of FM patients. In bilateral thalamus, IPL, contralateral precuneus, calcarine and ipsilateral insula, BOLD signal of pre-treatment was greater than post-treatment.</p

Commonly activated regions in pre-treatment and post-treatment.

<p>Functional magnetic resonance images showing activation in two regions, the supramarginal gyrus (arrow in left image) and inferior frontal gyrus (arrow in right image), during pressure-pain stimulation of subjectively strong intensity at both pre-treatment (yellow) and post-treatment (red) in the responder subgroup of FM patients.</p

Outline of the study design and classification of subjects used for evaluation of the effectiveness of pregabalin in the treatment of patients with fibromyalgia, using fMRI.

<p>Outline of the study design and classification of subjects used for evaluation of the effectiveness of pregabalin in the treatment of patients with fibromyalgia, using fMRI.</p

Comparison between FM patients and healthy controls.

<p>Augmented brain activation regions in FM patients compared with healthy controls resulting from the same level of subjective pain intensity (GBS level 14). Regions are Bilateral Supramarginal gyrus, ipsilateral cerebellum, contralateral calcarine, STG, IFG, thalamus and insula.</p

Baseline characteristics between OSA and no OSA groups.

Baseline characteristics between OSA and no OSA groups.</p

Prognostic factors for mortality in patients with IPF by Cox proportional hazards model.

Prognostic factors for mortality in patients with IPF by Cox proportional hazards model.</p