8,196 research outputs found
Prevention of cisplatin-induced hearing loss in children: Informing the design of future clinical trials.
Cisplatin is an essential chemotherapeutic agent in the treatment of many pediatric cancers. Unfortunately, cisplatin-induced hearing loss (CIHL) is a common, clinically significant side effect with life-long ramifications, particularly for young children. ACCL05C1 and ACCL0431 are two recently completed Childrens Oncology Group studies focused on the measurement and prevention of CIHL. The purpose of this paper was to gain insights from ACCL05C1 and ACCL0431, the first published cooperative group studies dedicated solely to CIHL, to inform the design of future pediatric otoprotection trials. Use of otoprotective agents is an attractive strategy for preventing CIHL, but their successful development must overcome a unique constellation of methodological challenges related to translating preclinical research into clinical trials that are feasible, evaluate practical interventions, and limit risk. Issues particularly important for children include use of appropriate methods for hearing assessment and CIHL severity grading, and use of trial designs that are well-informed by preclinical models and suitable for relatively small sample sizes. Increasing interest has made available new funding opportunities for expanding this urgently needed research
Tau functions as Widom constants
We define a tau function for a generic Riemann-Hilbert problem posed on a
union of non-intersecting smooth closed curves with jump matrices analytic in
their neighborhood. The tau function depends on parameters of the jumps and is
expressed as the Fredholm determinant of an integral operator with block
integrable kernel constructed in terms of elementary parametrices. Its
logarithmic derivatives with respect to parameters are given by contour
integrals involving these parametrices and the solution of the Riemann-Hilbert
problem. In the case of one circle, the tau function coincides with Widom's
determinant arising in the asymptotics of block Toeplitz matrices. Our
construction gives the Jimbo-Miwa-Ueno tau function for Riemann-Hilbert
problems of isomonodromic origin (Painlev\'e VI, V, III, Garnier system, etc)
and the Sato-Segal-Wilson tau function for integrable hierarchies such as
Gelfand-Dickey and Drinfeld-Sokolov.Comment: 26 pages, 6 figure
UBVI Surface Photometry of the Spiral Galaxy NGC 300 in the Sculptor Group
We present UBVI surface photometry for 20.'5 X 20.'5 area of a late-type
spiral galaxy NGC 300. In order to understand the morphological properties and
luminosity distribution characteristics of NGC 300, we have derived isophotal
maps, surface brightness profiles, ellipticity profiles, position angle
profiles, and color profiles. By merging the I-band data of our surface
brightness measurements with those of Boeker et al. (2002) based on Hubble
Space Telescope observations, we have made combined I-band surface brightness
profiles for the region of 0."02 < r < 500" and decomposed the profiles into
three components: a nucleus, a bulge, and an exponential disk.Comment: 16 pages(cjaa209.sty), Accepted by the Chinese J. Astron. Astrophys.,
Fig 2 and 8 are degraded to reduce spac
A Spectral Line Survey from 138.3 to 150.7 GHZ toward Orion-KL
We present the results of a spectral line survey from 138.3 to 150.7 GHz
toward Orion-KL. The observations were made using the 14 m radio telescope of
Taeduk Radio Astronomy Observatory. Typical system temperatures were between
500 and 700 K, with the sensitivity between K in units of .
A total of 149 line spectra are detected in this survey. Fifty lines have
been previously reported, however we find 99 new detections. Among these new
lines, 32 are `unidentified', while 67 are from molecular transitions with
known identifications. There is no detection of H or He recombination lines.
The identified spectra are from a total of 16 molecular species and their
isotopic variants. In the range from 138.3 to 150.7 GHz, the strongest spectral
line is the J=3-2 transition of CS molecule, followed by transitions of the
, , , and . Spectral lines from
the large organic molecules such as , , , and are prominent; with 80 % of the
identified lines arising from transitions of these molecules. The rotational
temperatures and column densities are derived using the standard rotation
diagram analysis for (), , and with and . These estimates are fairly comparable to the values for the
same molecule in other frequency regions by other studies.Comment: 10 figures, 2 tex files for a manuscript and tables, accepted to Ap
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