Maximizing The Impact Of Improvement Efforts On Customer Satisfaction

When a customer satisfaction survey consists of a large number of attributes (questionnaire items), determination of critical attributes that would make the biggest impact on customers’ overall satisfaction could be important, but very tedious and time-consuming process. Even though the critical attributes are identified, the improvement efforts toward these attributes are often misdirected and wasted because of the mismatch between the improvement efforts and the critical needs of the affected customer group. This paper introduces a method with which improvement efforts can be tailored to the needs of the customer group who could bring the most impactful influence on improving customer satisfaction. For the critical attribute considered, the percentage of customers who assigned a specific satisfaction rating is obtained, and the cumulative percentages of customers are examined and the target group of customers to whom the improvement efforts would be tailored is identified. The piecewise linear approximation method is also discussed to estimate the non-linear relationship of the attribute, which also may help determine the target customer group. The overall shape of the piecewise function and the slopes at the line segments may be used in determining which attributes are satisfaction-maintaining or satisfaction-enhancing, and where and how the improvement efforts should be focused in order to maximize the effectiveness of the improvement efforts

Pathological and protective roles of dendritic cells in Mycobacterium tuberculosis infection: Interaction between host immune responses and pathogen evasion

Dendritic cells (DCs) are principal defense components that play multifactorial roles in translating innate immune responses to adaptive immunity in Mycobacterium tuberculosis (Mtb) infections. The heterogeneous nature of DC subsets follows their altered functions by interacting with other immune cells, Mtb, and its products, enhancing host defense mechanisms or facilitating pathogen evasion. Thus, a better understanding of the immune responses initiated, promoted, and amplified or inhibited by DCs in Mtb infection is an essential step in developing anti-tuberculosis (TB) control measures, such as host-directed adjunctive therapy and anti-TB vaccines. This review summarizes the recent advances in salient DC subsets, including their phenotypic classification, cytokine profiles, functional alterations according to disease stages and environments, and consequent TB outcomes. A comprehensive overview of the role of DCs from various perspectives enables a deeper understanding of TB pathogenesis and could be useful in developing DC-based vaccines and immunotherapies

Two opposite hysteresis curves in semiconductors with mobile dopants

Recent experimental researches on semiconductors with mobile dopants (SMD) have reported unconventional hysteretic current-voltage (I-V) curves, which form dynamically in either one of the two opposite directions, the counter-figure-eight and figure-eight ways. However the fundamental theory for the formation of the two directions is still absent, and this poses a major barrier for researches oriented to applications. Here, we introduce a theoretical model to explain the origin of the two directions, and find that the two ways originate from the spatial inhomogeneity of the dopant distribution in SMD. The counter-figure-eight (figure-eight) way of the hysteretic curve is obtained when dopants are driven from far from (near) the Schottky interface to the opposite side in the SMD. This finding indicates that the directions of hysteretic curve in SMD can be controlled.Comment: 5 pages, 4 figure

An Active and Soft Hydrogel Actuator to Stimulate Live Cell Clusters by Self-folding

The hydrogels are widely used in various applications, and their successful uses depend on controlling the mechanical properties. In this study, we present an advanced strategy to develop hydrogel actuator designed to stimulate live cell clusters by self-folding. The hydrogel actuator consisting of two layers with different expansion ratios were fabricated to have various curvatures in self-folding. The expansion ratio of the hydrogel tuned with the molecular weight and concentration of gel-forming polymers, and temperature-sensitive molecules in a controlled manner. As a result, the hydrogel actuator could stimulate live cell clusters by compression and tension repeatedly, in response to temperature. The cell clusters were compressed in the 0.7-fold decreases of the radius of curvature with 1.0 mm in room temperature, as compared to that of 1.4 mm in 37 degrees C. Interestingly, the vascular endothelial growth factor (VEGF) and insulin-like growth factor-binding protein-2 (IGFBP-2) in MCF-7 tumor cells exposed by mechanical stimulation was expressed more than in those without stimulation. Overall, this new strategy to prepare the active and soft hydrogel actuator would be actively used in tissue engineering, drug delivery, and micro-scale actuators