The impact of store atmospherics and consumer attitudes on in-store behavior – What determines the buying decision of functional food?

Thesis purpose: The aim of this paper is to extend the knowledge of what influences the purchase decision of functional food in the store. By applying the M-R model in a new setting - the dairy department in grocery retailing in Sweden - and adding variables related to health attitudes, the aim is to contribute to existing research concerning in-store purchase decision making and store environment as well as consumer attitudes. Methodology: This thesis employs a quantitative strategy with a deductive approach and data has been collected with questionnaires. Theoretical perspective: Environmental psychology serves as an overarching framework where, more specifically, certain aspects of store atmospherics and some variables concomitant to health attitudes provide the theoretical base. Empirical data: The empirical data consists of customer purchasing a functional food product, Proviva, and this is contrasted with a test group, Bravo. Conclusion: Health variables had a greater impact on functional food customers than did the environmental factors. Environmental factors also seemed to be of minor importance for the test group. However they appeared to have greater impact on customers who made their purchase decisions in-store irrespective of product category. As the influence of health factors are established outside the retail context, the decision to purchase of functional food is made prior to entering the store

Myocardial biomarkers for prediction of cardiovascular disease

Abstract. The identification of those persons in the population who have the highest risk of future cardiovascular events is important for targeting intensive preventive efforts. This can be reliably done using a handful of long since established risk factors. The unmet need for new molecular biomarkers for prediction of cardiovascular events in the general population is therefore low. In order for a new biomarker to be used clinically for risk prediction, a statistically significant association of levels of the biomarker to adverse outcome is not enough, but the biomarker should also be demonstrated to add discriminative capacity beyond established risk factors. In contrast to the limited value of new biomarkers for risk prediction, their usefulness for unraveling the pathophysiology of cardiovascular disease is large. The myocardium is the source of a vast number of interesting biomarkers, of which a few may be useful for risk prediction in the general population. Two of these, troponin-I and the N-terminal fragment of brain natriuretic peptide, have passed tests of added discriminatory value. Numerous other biomarkers produced by cardiomyocytes or non-cardiomyocytes in the myocardium are promising, and if they are not proven useful for risk prediction, they will unquestionably enhance our understanding of cardiovascular disease. Keywords: Risk, epidemiology, population, biomarker, peptide, myocardium The need for prediction and prevention of cardiovascular events Cardiovascular diseases kill half of the population in developed countries, and seriously disable a further large number. A high cardiovascular disease death rate in elderly persons is unavoidable, but prevention of cardiovascular deaths in younger individuals is highly prioritized, as recently outlined in the European Heart Health Charter Sudden cardiac death is sometimes the first manifestation of cardiovascular disease, and traditional risk factors can be identified beforehand in a minority of these persons In order to prevent as many of premature cardiovascular deaths as possible, the Charter therefore calls for the use of both the population strategy (treating the whole population with measures such as smoking prevention or cessation, physical activity, and fruit and vegetable intake) and the high-risk strategy (identifying persons at high risk and treating risk factors aggressively). This article reviews some of the tools available for the latter strategy. The role of biomarkers in the identification of high-risk persons The term risk factor was coined fifty years ag

Combined effects of overweight and smoking in late adolescence on subsequent mortality: nationwide cohort study

Objective To investigate the combined effects on adult mortality of overweight and smoking in late adolescence

Are local fisheries important for marine tourism? A case study of the Swedish fishing village Träslövsläge

Coastal fishing fleets are declining in many parts of Europe. In Sweden, this has left many traditional fishing harbours with no or very few active fishers. This might have effects on the marine tourism industry where the existence of commercial fishing is part of the visitors’ tourism experience. In this paper in-depth interviews with local representatives for the tourism sector are combined with a questionnaire to 647 tourists visiting the Swedish harbour of Träslövsläge in 2020. A travel-cost analysis shows that tourists value the existence of fishing vessels to about 9 percent of the total value of the visit, while fishing architecture and a harbour with active commercial fisheries are lower valued. The importance of the fishing attributes varies substantially among tourists. From the interviews it can be concluded that the fishery is important for characterizing the village, but that the tourism experience also needs other activities such as restaurants

Association of blood pressure in late adolescence with subsequent mortality: cohort study of Swedish male conscripts

Objective To investigate the nature and magnitude of relations of systolic and diastolic blood pressures in late adolescence to mortality

Immune response to SARS-CoV-2 mRNA vaccination in multiple sclerosis patients after rituximab treatment interruption

Peripheral B cell depletion via anti-CD20 treatment is a highly effective disease-modifying treatment for reducing new relapses in multiple sclerosis (MS) patients. A drawback of rituximab (RTX) and other anti-CD20 antibodies is a poor immune response to vaccination. While this can be mitigated by treatment interruption of at least six months prior to vaccination, the timing to resume treatment while maintaining subsequent vaccine responses remains undetermined. Here, we characterized SARS-CoV-2 S-directed antibody and B cell responses throughout three BNT162b2 mRNA vaccine doses in RTX-treated MS patients, with the first two doses given during treatment interruption. We examined B-cell mediated immune responses in blood samples from patients with RTX-treated MS throughout three BNT162b2 vaccine doses, compared to an age- and sex-matched healthy control group. The first vaccine dose was given 1.3 years (median) after the last RTX infusion, the second dose one month after the first, and the third dose four weeks after treatment re-initiation. We analyzed SARS-CoV-2 S-directed antibody levels using enzyme-linked immunosorbent assay (ELISA), and the neutralization capacity of patient serum against SARS-CoV-2 S-pseudotyped lentivirus using luciferase reporter assay. In addition, we assessed switched memory (CD19+CD20+CD27+IgD-), unswitched memory (CD19+CD20+CD27+IgD+), naïve (CD19+CD20+CD27-IgD+), and double negative (DN, CD19+CD20+CD27-IgD-) B cell frequencies, as well as their SARS-CoV-2 S-specific (CoV+) and Decay Accelerating Factor-negative (DAF-) subpopulations, using flow cytometry. After two vaccine doses, S-binding antibody levels and neutralization capacity in SARS-CoV-2-naïve MS patients were comparable to vaccinated healthy controls, albeit with greater variation. Higher antibody response levels and CoV+-DN B cell frequencies after the second vaccine dose were predictive of a boost effect after the third dose, even after re-initiation of rituximab treatment. MS patients also exhibited lower frequencies of DAF- memory B cells, a suggested proxy for germinal centre activity, than control individuals. S-binding antibody levels in RTX-treated MS patients after two vaccine doses could help determine which individuals would need to move up their next vaccine booster dose or postpone their next RTX infusion. Our findings also offer first indications on the potential importance of antigenic stimulation of DN B cells and long-term impairment of germinal centre activity in rituximab-treated MS patients

Drug Treatment in Older People before and after the Transition to a Multi-Dose Drug Dispensing System - A Longitudinal Analysis

Tverrsnittstudie, undersøker assosiasjonen mellom multidose og polyfarmasi hos eldre.Background: an association has been found between multi-dose drug dispensing (MDD) and use of many drugs. The aim of this study was to investigate the nature of this association, by performing a longitudinal analysis of the drug treatment before and after the transition to MDD. Methods: inclusion critera in this register-based study were inhabitants in Region Västra Götaland, Sweden, who, at ≥65 years of age and between 1st July 2006 and 30th June 2010, filled their first MDD prescription. For each individual, prescribed drugs were estimated at three month intervals before and after (maximum 3 years, respectively) the first date of filling an MDD prescription (index date). Results: a total of 30,922 individuals matched the inclusion criteria (mean age: 83.2 years; 59.9% female). There was a temporal association between the transition to MDD and an increased number of drugs: 5.463.9 and 7.563.8 unique drugs three months before and after the index date, respectively, as well as worse outcomes on several indicators of prescribing quality. When either data before or after the index date were used, a multi-level regression analysis predicted the number of drugs at the index date at 5.76 (95% confidence limits: 5.71; 5.80) and 7.15 (7.10; 7.19), respectively, for an average female individual (83.2 years, 10.8 unique diagnoses, 2.4 healthcare contacts/three months). The predicted change in the number of drugs, from three months before the index date to the index date, was greater when data before this date was used as compared with data after this date: 0.12 (0.09; 0.14) versus 0.02 (20.01; 0.05). Conclusions: after the patients entered the MDD system, they had an increased number of drugs, more often potentially harmful drug treatment, and fewer changes in drug treatment. These findings support a causal relationship between such a system and safety concerns as regards prescribing practices

Left ventricular geometric patterns and adaptations to hemodynamics are similar in elderly men and women

<p>Abstract</p> <p>Background</p> <p>Common conditions such as obesity and hypertension result in hemodynamic alterations that will induce remodeling of the left ventricle (LV). However, differences between the genders in the relationship of hemodynamics to LV geometry are not well known.</p> <p>The present study aims to investigate differences between the genders in this respect, in a sample of elderly persons.</p> <p>Methods</p> <p>Echocardiography and Doppler was performed in a population-based sample aged 70 - The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (n = 922).</p> <p>Hemodynamic patterns obtained by echocardiography and Doppler were evaluated in relation to four LV geometric groups (normal, concentric remodeling, eccentric hypertrophy and concentric hypertrophy).</p> <p>Results</p> <p>No significant difference between the genders was observed regarding the prevalence of the LV geometric groups.</p> <p>Mean values of most evaluated echocardiography and Doppler variables differed between men and women, such as LA, IVS, LVEDD and IVRT, but the relationship of hemodynamic variables to LV geometric groups did not differ between the genders.</p> <p>Conclusions</p> <p>Although mean values of many echocardiographic variables differed between men and women, the LV geometric adaptations to a given hemodynamic load appear similar in both genders.</p

Elevated Levels of the Endogenous Retrovirus ERV3 in Human Sebaceous Glands

ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long aria of chromosome 7. Long terminal repeat–envelope (env) gene spliced mRNAs of 9 and 3.5kb are widely expressed in human tissues and cells, but gag-pol mRNAs have not been found. Furthermore, the env gp70 gene contains an open reading frame throughout its length. The highest expression of ERV3 mRNA detected so far is in placenta and the lowest in choriocarcinoma cell lines. We have previously shown that the human monoblastic cell line U-937 and some normal and neoplastic tissues also express high levels of ERV3 env message by Northern blot analysis; however, this method does not distinguish between mRNA expression in different cell types in tissues. In this report, we have studied the ERV3 mRNA expression in specific cell types of human skin by in situ hybridization. We found high levels expression of ERV3 env mRNA in human sebaceous glands in normal skin and dermoid cysts of the ovary. In all glands, the expression is maximal in the periphery of the lobule and ceases towards the center in the region of characteristic holocrine secretion. Since it is known that the regulation of sebaceous glands is primarily via steroid hormones, particularly androgens, it is possible that expression of ERV3 is hormone dependent