Synthesis and anticancer activity evaluation of some hemin and hematoporphyrin derivatives

388-393Sulphamerazine, sulphadiazine, and sulphaguanidine are coupled with hemin to give bis coupled products 1a, 1b and 1c respectively. 3, 4-Diphenyliminothiazoline, sulphamerazine, sulphaacetamide, sulphathiazole and sulphadiazine on coupling with hematoporphyrin give bis coupled products 2a, 2b, 2c, 2d and 2e respectively. Compounds 1a-c and 2a-e have been screened for anticancer activity against a small panel of six cancer cell lines consisting of prostate(DU 145), colon (HT29), melanoma (LOX), breast(MCF7 and MCF7/ADR) and CNS(U251) tumors. Best GI50 (concentration which inhibits the cell growth by 50%) values are shown by 2c, 2.2μM(prostate tumor, cell line DU145); 2c 13.0μM(colon tumor, cell line HT29); 2b, 3.4μM(melanoma tumor, cell line LOX); 2c, 9.7μM(breast tumor, cell line MCF7); 2a, 3.1μM(breast, tumor, cell line MCF7/ADR) and 1c, 3.4μM(CNS tumor, cell line U251) respectively. Out of all the compounds reported here GI50 value shown by 2a i.e.3.1μM against breast, tumor (MCF7/ADR) is quite close to the GI50 value i.e. 1.8μM, of standard drug doxorubicin

Development and validation of integrated yoga module for obesity in adolescents

Background: Obesity is a growing global epidemic and cause of noncommunicable diseases. Yoga is one of the effective ways to reduce stress which is one of the causes of obesity. Nowadays, children in adolescent age are more prone to get obese due to lack of physical activity making them more sedentary. Aim: To identify the design and validation of Integrated Approach of Yoga Therapy Module (IAYTM) for obesity in adolescents. Materials and Methods: First phase – IAYTM for obesity was designed based on the literature review of classical texts and recently published research articles. Second phase – Designed IAYTM was validated by 16 subject matter (yoga) experts. Content-validity ratio (CVR) was analyzed using Lawshe's formula. Results: Yoga practices were designed for Integrated Yoga Module for Obesity in Adolescents. Yoga practices with CVR ≥0.5 and which were validated by 16 yoga experts and approved in faculty group discussion were included in final Integrated Yoga Therapy Module. Conclusion: The yoga practices were designed and validated for IAYTM for obesity in adolescents