The anchovy reduction fishery for the 1976-77 season

The 1976-77 anchovy season ended with landings of 92,515 mt (101,433 tons) in southern California and 4,571 mt (5,041 tons) in central California. Southern California catches were dominated by age groups III (27%) and 0 (28%) while 77% of central California's landings were age groups III through VI. Numerical sex ratios were calculated to be 1.1:l and 2:l female to male for southern and central California respectively. (23pp.

The anchovy reduction fishery for the 1977-78 season

Landings for the 1977-78 season were 62,118 metric tons (68,476 tons) in southern California and 6,541 metric tons (7,212 tons) in central California. The southern area's samples were characterized by the dominance of the 1976 year class (38%) while central California data indicated the 1977 year class (38%) as the most abundant year class. Sex ratios indicated a near 1:1 ratio for both southern and central California. (24pp.

Status of Pacific mackerel spawning population, 1975

Three methods were used to determine the Pacific mackerel population. The tag and recovery method estimated the population at 620 short tons. The other two estimates were based on regression techniques of partyboat catches and these results yielded 2,921 tons and 1,385 tons, respectively. All three estimates were below the 10,000 tons prescribed for a fishery and thus no harvest could be allowed. (14pp.

The Northern Anchovy reduction fishery for the 1978-79 through 1981-82 seasons

Nearly 49,000 metric tons (MT) of anchovies were taken during the 1978-79 season, followed by 32,390 MT in 1979-80, 60,678 MT in 1980-81 and 45,150 MT in 1981-82. A total of 14,076 fish was sampled during the four seasons for age, length and sex. The fishery during the four seasons consisted mainly of young-of-the-year and age groups I and II fish. The 1978 and 1979 yr classes comprised the major share of the catch. Seasonal mean lengths varied from 112 mm standard length (SL) in the 1979-80 season to 122 mm SL for the 1981-82 season. Female to male sex ratios ranged from 1.17:l (1978-79 season) to 1.59:l (1979-80 season). (28pp.

Northern anchovy age and size composition, 1974-75 season

The California anchovy reduction fishery amounted to 105,767 megagrams (116,588 short tons) for the 1974-75 season. Southern California catch was dominated by age-group II (1972 year class) with substantial numbers of age groups III (1971 year class) and IV (1970 year class). Central California's anchovy catch consisted of similar age groups II, III and IV (1972, 1971 and 1970 year classes). Document has 23 pages

The northern anchovy fishery for the 1975-76 season

Anchovy landings for the 1975-76 season totaled 127,829 mg (140,906 short tons). Southern California samples exhibited the preponderance of age group II (1973 year class) followed by age group III (1972 year class). Younger age groups were present in below average numbers. Numerical sex ratios were calculated to be 1.5:l and 1.9:l female to male for southern and central California respectively. (27pp.

Exo-C: a probe-scale space observatory for direct imaging and spectroscopy of extrasolar planetary systems

"Exo-C" is NASAs first community study of a modest aperture space telescope mission that is optimized for high contrast observations of exoplanetary systems. The mission will be capable of taking optical spectra of nearby exoplanets in reflected light, discovering previously undetected planets, and imaging structure in a large sample of circumstellar disks. It will obtain unique science results on planets down to super-Earth sizes and serve as a technology pathfinder toward an eventual flagship-class mission to find and characterize habitable Earth-like exoplanets. We present the mission/payload design and highlight steps to reduce mission cost/risk relative to previous mission concepts. Key elements are an unobscured telescope aperture, an internal coronagraph with deformable mirrors for precise wavefront control, and an orbit and observatory design chosen for high thermal stability. Exo-C has a similar telescope aperture, orbit, lifetime, and spacecraft bus requirements to the highly successful Kepler mission (which is our cost reference). Much of the needed technology development is being pursued under the WFIRST coronagraph study and would support a mission start in 2017, should NASA decide to proceed. This paper summarizes the study final report completed in March 2015.United States. National Aeronautics and Space Administration. Astrophysics Divisio

Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous MTAP-deleted cell lines in culture show elevation of MTAP\u27s substrate metabolite, methylthioadenosine (MTA). High levels of MTA inhibit protein arginine methyltransferase 5 (PRMT5), which sensitizes MTAP-deleted cells to PRMT5 and methionine adenosyltransferase 2A (MAT2A) inhibition. While this concept has been extensively corroborated in vitro, the clinical relevance relies on exhibiting significant MTA accumulation in human glioblastoma. In this work, using comprehensive metabolomic profiling, we show that MTA secreted by MTAP-deleted cells in vitro results in high levels of extracellular MTA. We further demonstrate that homozygous MTAP-deleted primary glioblastoma tumors do not significantly accumulate MTA in vivo due to metabolism of MTA by MTAP-expressing stroma. These findings highlight metabolic discrepancies between in vitro models and primary human tumors that must be considered when developing strategies for precision therapies targeting glioblastoma with homozygous MTAP deletion

Exo-C: a probe-scale space observatory for direct imaging and spectroscopy of extrasolar planetary systems

"Exo-C" is NASAs first community study of a modest aperture space telescope mission that is optimized for high contrast observations of exoplanetary systems. The mission will be capable of taking optical spectra of nearby exoplanets in reflected light, discovering previously undetected planets, and imaging structure in a large sample of circumstellar disks. It will obtain unique science results on planets down to super-Earth sizes and serve as a technology pathfinder toward an eventual flagship-class mission to find and characterize habitable Earth-like exoplanets. We present the mission/payload design and highlight steps to reduce mission cost/risk relative to previous mission concepts. Key elements are an unobscured telescope aperture, an internal coronagraph with deformable mirrors for precise wavefront control, and an orbit and observatory design chosen for high thermal stability. Exo-C has a similar telescope aperture, orbit, lifetime, and spacecraft bus requirements to the highly successful Kepler mission (which is our cost reference). Much of the needed technology development is being pursued under the WFIRST coronagraph study and would support a mission start in 2017, should NASA decide to proceed. This paper summarizes the study final report completed in March 2015

Exo-C: a probe-scale space observatory for direct imaging and spectroscopy of extrasolar planetary systems

"Exo-C" is NASAs first community study of a modest aperture space telescope mission that is optimized for high contrast observations of exoplanetary systems. The mission will be capable of taking optical spectra of nearby exoplanets in reflected light, discovering previously undetected planets, and imaging structure in a large sample of circumstellar disks. It will obtain unique science results on planets down to super-Earth sizes and serve as a technology pathfinder toward an eventual flagship-class mission to find and characterize habitable Earth-like exoplanets. We present the mission/payload design and highlight steps to reduce mission cost/risk relative to previous mission concepts. Key elements are an unobscured telescope aperture, an internal coronagraph with deformable mirrors for precise wavefront control, and an orbit and observatory design chosen for high thermal stability. Exo-C has a similar telescope aperture, orbit, lifetime, and spacecraft bus requirements to the highly successful Kepler mission (which is our cost reference). Much of the needed technology development is being pursued under the WFIRST coronagraph study and would support a mission start in 2017, should NASA decide to proceed. This paper summarizes the study final report completed in March 2015