Synthesis of Polyheteroaromatic Compounds via Rhodium-Catalyzed Multiple C–H Bond Activation and Oxidative Annulation

Polyheteroaromatic compounds are potential optoelectronic conjugated materials due to their electro- and photochemical properties. Transition-metal-catalyzed multiple C–H activation and sequential oxidative annulation allows rapidly assembling of those compounds from readily available starting materials. A rhodium-catalyzed cascade oxidative annulation of β-enamino esters or 4-aminocoumarins with internal alkynes is described to access those compounds, featuring multiple C–H/N–H bond cleavages and sequential C–C/C–N bond formations in one pot