57,610 research outputs found

    Low-temperature nodal-quasiparticle transport in lightly doped YBa_{2}Cu_{3}O_{y} near the edge of the superconducting doping regime

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    In-plane transport properties of nonsuperconducting YBa_{2}Cu_{3}O_{y} (y = 6.35) are measured using high-quality untwinned single crystals. We find that both the a- and b-axis resistivities show log(1/T) divergence down to 80 mK, and accordingly the thermal conductivity data indicate that the nodal quasiparticles are progressively localized with lowering temperature. Hence, both the charge and heat transport data do not support the existence of a "thermal metal" in nonsuperconducting YBa_{2}Cu_{3}O_{y}, as opposed to a recent report by Sutherland {\it et al.} [Phys. Rev. Lett. {\bf 94}, 147004 (2005)]. Besides, the present data demonstrate that the peculiar log(1/T) resistivity divergence of cuprate is {\it not} a property associated with high-magnetic fields.Comment: 4 pages, 3 figures. Our previous main claim that the pseudogap state of cuprates is inherently insulating was found to be erroneous and has been retracted; the paper now focuses on the log(1/T) resistivity divergence and its implication

    Large magnetothermal conductivity in GdBaCo_{2}O_{5+x} single crystals

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    To study the effects of paramagnetic spins on phonons, both the in-plane and the c-axis heat transport of GdBaCo_{2}O_{5+x} (GBCO) single crystals are measured at low temperature down to 0.36 K and in magnetic field up to 16 T. It is found that the phonon heat transport is very strongly affected by the magnetic field and nearly 5 times increase of the thermal conductivity in several Tesla field is observed at 0.36 K. It appears that phonons are resonantly scattered by paramagnetic spins in zero field and the application of magnetic field removes such strong scattering, but the detailed mechanism is to be elucidated.Comment: 5 pages, 5 figures, accepted for publication in Phys. Rev.

    The quantitative reconstruction of the palaeoclimate between 5200 and 4300 cal yr BP in the Tianshui Basin, NW China

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    The quantitative reconstruction of the palaeoclimate is a prerequisite for understanding climate processes at time scales of centuries and millennia. Here, the coexistence approach (CA) was applied to reconstruct climatic factors quantitatively based on the fossil charcoal records between 5200 and 4300 cal yr BP in the Tianshui Basin, NW China. The CA analysis showed that the climate of the Tianshui Basin belonged to the northern subtropical zone between 5200 and 4300 cal yr BP. The mean annual temperature (MAT) was approximately 13.2 °C, and the mean annual precipitation (MAP) was approximately 778 mm between 5200 and 4900 cal yr BP. The MAT was approximately 13.2 °C, and the MAP was approximately 688 mm between 4800 and 4300 cal yr BP. The MAT was approximately 2.2 °C higher than today, and the MAP was approximately 280 mm higher than today from 5200 to 4900 cal yr BP. The MAT was also approximately 2.2 °C higher than today from 4800 to 4300 cal yr BP, while the MAP was approximately 196 mm higher than today. No abrupt cold event occurred between 5200 and 4300 cal yr BP; however, a drought tendency appeared after around 4800 cal yr BP

    Evaluation of management strategies for the operation of high-speed railways in China

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    High-Speed Train (HST) operations have recently been introduced in rail passenger transportation markets worldwide. Although the technologies for such operations have levelled at speeds of around 300 km/h, the operating parameters to be adopted in each application will differ from country to country. The operating environment will be one of the crucial success factors for the implementation of HST operations in China. This paper compares three different management/ownership models which might be used in China. The paper analyzes the characteristics of each model and proposes an optimal plan of an operational system to develop HST operations in China by using a hierarchy goals achievement matrix approach

    Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.

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    DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein degradation, is phosphorylated by DNA-PK and recruited to DNA double-strand break sites to regulate DNA damage repair. However, it is not clear whether VCP is involved in DNA-PKcs (DNA-PK catalytic subunit) degradation or whether it regulates the radiosensitivity of glioblastoma. Our data demonstrated that DNA-PKcs was ubiquitinated and bound to VCP. VCP knockdown resulted in the accumulation of the DNA-PKcs protein in glioblastoma cells, and the proteasome inhibitor MG132 synergised this increase. As expected, this increase promoted the efficiency of DNA repair in several glioblastoma cell lines; in turn, this enhanced activity decreased the radiation sensitivity and prolonged the survival fraction of glioblastoma cells in vitro. Moreover, the VCP knockdown in glioblastoma cells reduced the survival time of the xenografted mice with radiation treatment relative to the control xenografted glioblastoma mice. In addition, the VCP protein was also downregulated in ~25% of GBM tissues from patients (WHO, grade IV astrocytoma), and the VCP protein level was correlated with patient survival (R(2)=0.5222, P<0.05). These findings demonstrated that VCP regulates DNA-PKcs degradation and increases the sensitivity of GBM cells to radiation
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